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Replication Of Chromosomes In Budding Yeast

Award Number: R01GM129058
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/17/2019
PERIOD OF PERFORMANCE END DATE: 12/31/2027

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Replication Of Chromosomes In Budding Yeast - Abstract Our understanding of DNA replication and its relationship with chromatin structure, nuclear organization and gene transcription has advanced significantly through the development of genome-wide assays. Most genome-wide tools to study DNA replication utilize large populations of cells and report on the average behavior of the population; as such, many infrequent or stochastic events that occur as the replication fork progresses through chromatin are missed. Recently, we have developed novel methods to map DNA replication with single-molecule and single-nucleotide precision. In this proposal we will apply this new technology to understand how DNA synthesis can be completed when the replication machinery encounters obstacles. We will specifically test how RNA/DNA hybrids and G-quadruplex DNA influence the progression of DNA replication and whether DNA synthesis can be efficiently restarted downstream of an impediment. In addition to understanding the progression of replication through chromatin, we will also investigate how replication is competed during the process of termination. Using high-resolution assays, we have uncovered a critical role for the DNA helicase Rrm3 in replication termination. We will further define the role played by Rrm3 and test a novel hypothesis that Rrm3 may prevent catastrophic re- replication of the genome.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $411,861 )
2026	2026	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Biomedical Research and Research Training	000	7	12/11/2025	NON-COMPETING CONTINUATION	$411,861
														Subtotal = $411,861

Issue Date FY: 2025 ( Subtotal = $869,484 )
2025	2025	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Biomedical Research and Research Training	002	6	12/11/2024	NON-COMPETING CONTINUATION	$411,861
2025	2025	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Biomedical Research and Research Training	003	6	8/12/2025	NON-COMPETING CONTINUATION	$45,762
2025	2025	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Biomedical Research and Research Training	001	5	12/9/2024	COMPETING CONTINUATION	$411,861
2025	2024	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Biomedical Research and Research Training	001	5	12/9/2024	COMPETING CONTINUATION	$244
2025	2022	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Biomedical Research and Research Training	000	4	12/9/2024	NON-COMPETING CONTINUATION	-$244
														Subtotal = $869,484

Issue Date FY: 2024 ( Subtotal = $457,623 )
2024	2024	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVENUE	NEW YORK	NY	10065	NEW YORK	USA	Biomedical Research and Research Training	001	5	12/27/2023	COMPETING CONTINUATION	$460,223
2024	2024	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVENUE	NEW YORK	NY	10065	NEW YORK	USA	Biomedical Research and Research Training	002	5	1/12/2024	COMPETING CONTINUATION	-$2,600
2024	2022	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVENUE	NEW YORK	NY	10065	NEW YORK	USA	Biomedical Research and Research Training	000	4	12/19/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $457,623

Issue Date FY: 2022 ( Subtotal = $453,382 )
2022	2022	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Biomedical Research and Research Training	000	4	7/29/2022	NON-COMPETING CONTINUATION	$453,382
														Subtotal = $453,382

Issue Date FY: 2021 ( Subtotal = $453,382 )
2021	2021	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Biomedical Research and Research Training	000	3	7/30/2021	NON-COMPETING CONTINUATION	$453,382
														Subtotal = $453,382

Issue Date FY: 2020 ( Subtotal = $453,382 )
2020	2020	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Biomedical Research and Research Training	000	2	7/28/2020	NON-COMPETING CONTINUATION	$453,382
														Subtotal = $453,382

Issue Date FY: 2019 ( Subtotal = $453,382 )
2019	2019	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Biomedical Research and Research Training	000	1	9/17/2019	NEW	$453,382
														Subtotal = $453,382

Grand Total All Awards = $3,552,496

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Replication Of Chromosomes In Budding Yeast

Award Number: R01GM129058

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/17/2019

PERIOD OF PERFORMANCE END DATE: 12/31/2027

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