Wednesday, April 2, 2025 4/2/2025

Hyster (Rivas-Souchet) Diversity Supplement

Award Number: R01GM127703
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Hyster (Rivas-Souchet) Diversity Supplement - Asymmetric Photoenzymatic Csp3—Csp3 Decyanative Couplings Nitriles are present in a range of different biologically active molecules and can also serve as a synthetic handle to other functional groups, making their facile and stereoselective assembly crucial for modern drug development. The current methods to synthesize nitrile stereocenters are limited to Csp2–Csp3 precursors. Biocatalysis offers a unique approach to establish nitrile stereocenters with the added benefit of directed evolution for catalyst development. We propose a novel asymmetric Csp3–Csp3 coupling to forge tertiary nitrile stereocenter via photoenzymatic biocatalysis of malononitriles and readily available 𝛼𝛼-chloroamides. Preliminary work shows moderate to good yields and enantioselectivities of cross- coupled product accelerated by flavin-dependent ene-reductase (ERED). The current strategy for the continued advancement of this project is to: identify ideal conditions for the decyanative transformation, conduct a directed evolution campaign on the most selective ERED candidate, and investigate the underlying mechanism of this novel reactivity. This approach will allow the exploration of an enzyme- mediated reactive intermediates that can be directed into new stereoselective assemblies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $22,596 )
2025	2025	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	000	9	1/8/2025	SUPPLEMENT FOR EXPANSION	$22,596
														Subtotal = $22,596

Issue Date FY: 2024 ( Subtotal = $346,695 )
2024	2024	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	003	9	6/11/2024	NON-COMPETING CONTINUATION	$32,599
2024	2024	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	002	9	3/18/2024	NON-COMPETING CONTINUATION	$293,398
2024	2023	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	005	7	8/20/2024	COMPETING CONTINUATION	$0
2024	2023	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	001	8	11/21/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$278,143
2024	2023	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	7	11/21/2023	COMPETING CONTINUATION	-$257,445
2024	2023	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	006	8	8/20/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2024	2022	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	004	6	8/20/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $346,695

Issue Date FY: 2023 ( Subtotal = $318,629 )
2023	2023	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	7	2/16/2023	COMPETING CONTINUATION	$318,629
														Subtotal = $318,629

Issue Date FY: 2022 ( Subtotal = $297,504 )
2022	2022	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	6	3/3/2022	NON-COMPETING CONTINUATION	$267,754
2022	2022	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	001	6	7/20/2022	NON-COMPETING CONTINUATION	$29,750
														Subtotal = $297,504

Issue Date FY: 2021 ( Subtotal = $219,313 )
2021	2021	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	002	5	6/22/2021	NON-COMPETING CONTINUATION	$298,016
2021	2020	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	004	4	8/10/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$61
2021	2020	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	001	4	6/8/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$46,194
2021	2020	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	003	3	8/10/2021	NON-COMPETING CONTINUATION	-$61
2021	2020	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	000	3	6/8/2021	NON-COMPETING CONTINUATION	-$124,897
														Subtotal = $219,313

Issue Date FY: 2020 ( Subtotal = $310,237 )
2020	2020	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	000	3	2/26/2020	NON-COMPETING CONTINUATION	$310,237
														Subtotal = $310,237

Issue Date FY: 2019 ( Subtotal = $396,323 )
2019	2019	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	000	2	2/21/2019	NON-COMPETING CONTINUATION	$310,237
2019	2019	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	001	2	6/7/2019	SUPPLEMENT FOR EXPANSION	$86,086
														Subtotal = $396,323

Issue Date FY: 2018 ( Subtotal = $300,317 )
2018	2018	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	000	1	4/16/2018	NEW	$300,317
														Subtotal = $300,317

Grand Total All Awards = $2,211,614

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Hyster (Rivas-Souchet) Diversity Supplement

Award Number: R01GM127703

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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