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Development of an ultra-sensitive, laser-based, carbon-14 spectrometer for molecular speciation of liquid-chromatography analytes and small, biological samples

Award Number: R01GM127573
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2018
PERIOD OF PERFORMANCE END DATE: 05/31/2023

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Development of an ultra-sensitive, laser-based, carbon-14 spectrometer for molecular speciation of liquid-chromatography analytes and small, biological samples - The feasibility of laser-based, detection of carbon-14 at Accelerator Mass Spectrometer (AMS) sensitivities has been demonstrated, but these instruments require large samples sizes and lack compatibility with systems common to biological labs—such as liquid chromatography-mass spectrometry (LC-MS). With their ability to quickly detect and quantify ever smaller amounts of material, LC-MS systems are valued for their capacity to isolate individual biomolecules. As a result, LC-MS coupling is now stipulated for the success and adoption of new biological instrumentation. Consequently, we propose to develop a laser-based, carbon-14 spectrometer for biology using saturated-absorption cavity ring-down spectroscopy (SCARS). This instrument will have similar sensitivity to AMS (~10-15 14C/C limit-of-detection), the ability to handle nanogram to microgram sized samples, and the capability to measure analytes separated by LC systems. This level of carbon-14 sensitivity and the techniques it affords are currently restricted to room-sized AMS instruments that cost millions of dollars and require several dedicated Ph.D. level scientists for operation. The SCAR instrument would be much smaller (table-top sized), cheaper, and easier to operate. The accessibility coupled with the extreme sensitivity of this technology will enable high-throughput, small-sample-size experiments and bring carbon-14 measurements into the modern biological laboratory. This instrument will enhance LC/MS systems—providing a means to quantitatively analyze complex biochemical systems in any research lab. This will have an impact on biology from basic science experiments to more applied human subject studies in drug development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$13,236 )
2024	2021	LLNS DOE CONTRACTOR	7000 EAST AVENUE	LIVERMORE	CA	94551	ALAMEDA	USA	Biomedical Research and Research Training	000	4	2/21/2024	NON-COMPETING CONTINUATION	-$13,236
														Subtotal = -$13,236

Issue Date FY: 2021 ( Subtotal = $741,705 )
2021	2021	ENERGY LIVERMORE OFFICE, UNITED STATES DEPARTMENT OF	7000 E AVE	LIVERMORE	CA	94550	ALAMEDA	USA	Biomedical Research and Research Training	000	4	5/27/2021	NON-COMPETING CONTINUATION	$741,705
														Subtotal = $741,705

Issue Date FY: 2020 ( Subtotal = $739,997 )
2020	2020	ENERGY LIVERMORE OFFICE, UNITED STATES DEPARTMENT OF	7000 E AVE	LIVERMORE	CA	94550	ALAMEDA	USA	Biomedical Research and Research Training	000	3	5/25/2020	NON-COMPETING CONTINUATION	$739,997
														Subtotal = $739,997

Issue Date FY: 2019 ( Subtotal = $742,231 )
2019	2019	ENERGY LIVERMORE OFFICE, UNITED STATES DEPARTMENT OF	7000 E AVE	LIVERMORE	CA	94550	ALAMEDA	USA	Biomedical Research and Research Training	000	2	5/14/2019	NON-COMPETING CONTINUATION	$742,231
														Subtotal = $742,231

Issue Date FY: 2018 ( Subtotal = $753,462 )
2018	2018	ENERGY LIVERMORE OFFICE, UNITED STATES DEPARTMENT OF	7000 E AVE	LIVERMORE	CA	94550	ALAMEDA	USA	Biomedical Research and Research Training	000	1	8/10/2018	NEW	$753,462
														Subtotal = $753,462

Grand Total All Awards = $2,964,159

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Development of an ultra-sensitive, laser-based, carbon-14 spectrometer for molecular speciation of liquid-chromatography analytes and small, biological samples

Award Number: R01GM127573

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2018

PERIOD OF PERFORMANCE END DATE: 05/31/2023

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