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Dynamics of histone-DNA interaction

Award Number: R01GM123164
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2018
PERIOD OF PERFORMANCE END DATE: 01/31/2023

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Dynamics of histone-DNA interaction - Project Summary The long-term objective of this research program is to elucidate the roles of histone-DNA interactions in gene regulation. The nucleosome, the fundamental packing unit of the eukaryotic genome, imposes physical barriers to DNA access and needs to disassemble at least in part during various nuclear processes such as transcription elongation and chromatin remodeling. The kinetic pathways and rates of these processes are crucial components in gene regulation mechanisms and closely coupled to the dynamics of histone-DNA interactions. Elucidating the implications of dynamic histone-DNA interactions in gene regulation is an important and active subject of the current chromatin research. This project aims to elucidate how spontaneous dynamics of histone-DNA interactions contribute to regulating two important nuclear processes catalyzed by large enzyme complexes that translocate along DNA. The target processes are transcription elongation by RNA polymerase II and chromatin remodeling by INO80 both of which are essential for cell viability and healthy proliferation. The project will reveal how the strong yet dynamic histone-DNA interactions are implicated in regulating these processes based on three-color single-molecule fluorescence resonance energy transfer (smFRET) and single-molecule sub-ms motion analysis. These innovative approaches will enable an understanding of the molecular processes that allow these enzymes to access and act on nucleosomes and the end products of their activities at an unprecedented level of depth.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$261 )
2024	2021	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	4	11/30/2023	NON-COMPETING CONTINUATION	-$261
														Subtotal = -$261

Issue Date FY: 2021 ( Subtotal = $352,833 )
2021	2021	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	001	4	2/24/2021	NON-COMPETING CONTINUATION	$35,284
2021	2021	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	4	1/25/2021	NON-COMPETING CONTINUATION	$317,549
														Subtotal = $352,833

Issue Date FY: 2020 ( Subtotal = $352,946 )
2020	2020	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	3	1/30/2020	NON-COMPETING CONTINUATION	$317,651
2020	2020	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	001	3	3/20/2020	NON-COMPETING CONTINUATION	$35,295
														Subtotal = $352,946

Issue Date FY: 2019 ( Subtotal = $353,055 )
2019	2019	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	2	1/15/2019	NON-COMPETING CONTINUATION	$353,055
														Subtotal = $353,055

Issue Date FY: 2018 ( Subtotal = $353,161 )
2018	2018	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	1	1/31/2018	NEW	$353,161
														Subtotal = $353,161

Grand Total All Awards = $1,411,734

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Dynamics of histone-DNA interaction

Award Number: R01GM123164

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2018

PERIOD OF PERFORMANCE END DATE: 01/31/2023

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