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A Mathematical Theory of Transmissible Vaccines

Award Number: R01GM122079
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2016
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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A Mathematical Theory of Transmissible Vaccines - Each year, millions of people are harmed or killed by pathogens that spill over from wild or domestic animal reservoirs. A new approach to reducing the threat of spillover is to eliminate the pathogen from its animal reservoir using transmissible vaccines that move from animal to animal providing immunity to the pathogen as they go. Transmissible vaccines reduce the vaccination effort required for pathogen control within animal reservoirs and allow the vaccine to penetrate remote reservoir habitats where direct vaccination is impossible. Bringing this revolutionary idea to fruition requires that we engineer vaccines that simultaneously: 1) transmit efficiently from animal to animal, 2) stimulate a robust immune response to the target pathogen, and 3) maintain their integrity in the face of evolutionary pressures. This project will develop mathematical models that predict how these traits of the vaccine emerge from the interplay between vaccine replication and the animal’s immune response. These models will be parameterized and validated using laboratory studies of prototype transmissible vaccines that use murine cytomegalovirus (MCMV) as a vector backbone. We focus on MCMV as a vector because it is highly species specific, capable of superinfection, and provides a model for vaccine development across murine rodents that serve as important reservoirs for a wide range of human pathogens. The models will be validated using experiments with immune depleted mice that challenge their ability to explain both pattern and process. Work on this project capitalizes on an existing collaboration between experts in mathematical modeling, viral evolution, and murine cytomegalovirus.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $335,075 )
2024	2024	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	001	6	8/16/2024	NON-COMPETING CONTINUATION	$335,075
2024	2023	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	5	2/20/2024	COMPETING CONTINUATION	$0
														Subtotal = $335,075

Issue Date FY: 2023 ( Subtotal = $367,126 )
2023	2023	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	001	5	9/18/2023	COMPETING CONTINUATION	$367,126
2023	2019	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	4	10/29/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $367,126

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	4	3/10/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $252,945 )
2019	2019	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	4	4/29/2019	NON-COMPETING CONTINUATION	$252,945
														Subtotal = $252,945

Issue Date FY: 2018 ( Subtotal = $252,945 )
2018	2018	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	3	4/25/2018	NON-COMPETING CONTINUATION	$252,945
														Subtotal = $252,945

Issue Date FY: 2017 ( Subtotal = $252,639 )
2017	2017	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	001	2	6/6/2017	NON-COMPETING CONTINUATION	$25,264
2017	2017	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	2	4/14/2017	NON-COMPETING CONTINUATION	$227,375
														Subtotal = $252,639

Issue Date FY: 2016 ( Subtotal = $251,392 )
2016	2016	UNIVERSITY OF IDAHO	Admin Annex Fin Affiars	MOSCOW	ID	83843	LATAH	USA	Biomedical Research and Research Training	000	1	7/26/2016	NEW	$251,392
														Subtotal = $251,392

Grand Total All Awards = $1,712,122

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A Mathematical Theory of Transmissible Vaccines

Award Number: R01GM122079

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2016

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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