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Elucidating the regulators of ciliogenesis

Award Number: R01GM120776
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2011
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Elucidating the regulators of ciliogenesis - Primary cilia are antenna-like projections that emanate from the cell surface of most quiescent mammalian cells. Cilia are essential for sensing extracellular cues and growth factors. They assemble from centrosomes and are resorbed in a cell cycle-dependent manner. Many questions remain regarding the mechanisms that provoke cilium assembly and disassembly. For example, links between reorganization of cytoskeletal proteins, tubulin modifications, and nuclear anchoring have emerged, but mechanistic connections to cilium assembly and disassembly are not well understood. We have begun characterizing key proteins required for ciliogenesis, including Talpid3, a protein known to play a role in signaling. Using proteome-wide methods to identify Talpid3- interaction partners, we isolated two previously uncharacterized proteins, LRRC49 and C11orf49, that play a potent role in suppressing inappropriate cilium assembly and maintaining both tubulin glutamylation and nuclear morphology. In two Aims that combine cell biological and biochemical approaches with gene-editing and use of an in vivo model, we will (1) investigate a role for LRRC49 and C11orf49 in timely cilium assembly and disassembly, (2) examine how LRRC49 and C11orf49 regulate nuclear morphology and cytoskeleton assembly and dynamics, and (3) test the broad biological roles of tubulin glutamylases and their connections to ciliogenesis, microtubule stability, and nuclear envelope assembly. By investigating the function of key proteins that regulate cilium assembly and disassembly, as well as control of cytoskeleton organization and nuclear shape in vitro and in vivo, we will address fundamental questions related to mammalian cell growth and cell cycle progression.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,466,516 )
2026	2026	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	000	13	2/6/2026	COMPETING CONTINUATION	$1,466,516
2026	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	001	12	3/4/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,466,516

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	001	12	8/14/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	000	12	8/14/2024	NON-COMPETING CONTINUATION	$0
2024	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	002	12	8/14/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $668,318 )
2023	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	001	12	7/19/2023	SUPPLEMENT FOR EXPANSION	$102,520
2023	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	000	12	6/22/2023	NON-COMPETING CONTINUATION	$355,952
2023	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	002	12	8/4/2023	SUPPLEMENT FOR EXPANSION	$209,846
														Subtotal = $668,318

Issue Date FY: 2022 ( Subtotal = $355,952 )
2022	2022	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	001	11	6/21/2022	NON-COMPETING CONTINUATION	$355,952
2022	2021	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	000	10	2/8/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $355,952

Issue Date FY: 2021 ( Subtotal = $439,207 )
2021	2021	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	003	10	9/1/2021	SUPPLEMENT FOR EXPANSION	$83,255
2021	2021	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	002	10	6/29/2021	NON-COMPETING CONTINUATION	$355,952
2021	2020	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	001	9	6/12/2021	COMPETING CONTINUATION	$1
2021	2019	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	000	8	6/12/2021	NON-COMPETING CONTINUATION	-$1
														Subtotal = $439,207

Issue Date FY: 2020 ( Subtotal = $355,952 )
2020	2020	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	000	9	5/15/2020	COMPETING CONTINUATION	$355,952
														Subtotal = $355,952

Issue Date FY: 2019 ( Subtotal = $334,763 )
2019	2019	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	000	8	6/24/2019	NON-COMPETING CONTINUATION	$334,763
														Subtotal = $334,763

Issue Date FY: 2018 ( Subtotal = $334,763 )
2018	2018	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	000	7	5/23/2018	NON-COMPETING CONTINUATION	$334,763
														Subtotal = $334,763

Issue Date FY: 2017 ( Subtotal = $334,763 )
2017	2017	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	000	6	7/4/2017	NON-COMPETING CONTINUATION	$334,763
														Subtotal = $334,763

Issue Date FY: 2016 ( Subtotal = $334,763 )
2016	2016	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	000	5	8/30/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$334,763
														Subtotal = $334,763

Grand Total All Awards = $4,624,997

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Elucidating the regulators of ciliogenesis

Award Number: R01GM120776

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2011

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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