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Continued Development and Maintenance of the UltraScan Software

Award Number: R01GM120600
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2016
PERIOD OF PERFORMANCE END DATE: 09/16/2024

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Continued Development and Maintenance of the UltraScan Software - Project Summary/Abstract We propose to continue development and support for the UltraScan-III (US3) software suite and develop new code and methods to address challenging biomedical research questions that can be solved with the latest instruments available for analytical ultracentrifugation and at beamlines for small-angle X-ray and neutron scattering experiments (SAXS/SANS) experiments. UltraScan is a comprehensive toolkit for the analysis of data from hydrodynamic experiments and simulations. Such experiments include analytical ultracentrifugation, SAXS/SANS, as well as bead modeling simulations. Support for this project will assure continued availability of a mature multi-platform analysis suite with important and unique capabilities not found in any other software packages. Chief among them are tight integration of supercomputing capabilities, LIMS support for collaboration, and specialized analysis routines. US3 enjoys widespread use in the AUC and SAXS/SANS communities, and offers the most robust optimization and simulation algorithms available, resulting in unmatched detail. UltraScan provides the highest throughput, a flexible, modern GUI, and a comprehensive list of analysis routines. Proposed developments include automated data acquisition and analysis workflows, improvements in the fitting of floating data, improved two-dimensional grids, support for density distribution analysis critical for the accurate characterization and quantification of viral vectors, lipid nanoparticles loaded with cancer drugs or nucleic acids, and other vectors used for the delivery of medicines or CRISPR technology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	UNIVERSITY OF MONTANA	32 CAMPUS DR	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	000	8	4/1/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $334,353 )
2024	2024	UNIVERSITY OF MONTANA	32 CAMPUS DR	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	001	9	9/17/2024	COMPETING CONTINUATION	$334,353
2024	2023	UNIVERSITY OF MONTANA	32 CAMPUS DR	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	000	8	9/17/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $334,353

Issue Date FY: 2023 ( Subtotal = $293,074 )
2023	2023	UNIVERSITY OF MONTANA	32 CAMPUS DR	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	000	8	8/9/2023	NON-COMPETING CONTINUATION	$293,074
														Subtotal = $293,074

Issue Date FY: 2022 ( Subtotal = $534,946 )
2022	2022	UNIVERSITY OF MONTANA	32 CAMPUS DR MAIN HALL	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	001	7	8/25/2022	SUPPLEMENT FOR EXPANSION	$241,872
2022	2022	UNIVERSITY OF MONTANA	32 CAMPUS DR MAIN HALL	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	000	7	7/29/2022	NON-COMPETING CONTINUATION	$293,074
														Subtotal = $534,946

Issue Date FY: 2021 ( Subtotal = $293,074 )
2021	2021	UNIVERSITY OF MONTANA	32 CAMPUS DR MAIN HALL	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	001	6	8/4/2021	NON-COMPETING CONTINUATION	$293,074
2021	2019	UNIVERSITY OF MONTANA	32 CAMPUS DR MAIN HALL	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	000	4	7/10/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $293,074

Issue Date FY: 2020 ( Subtotal = $293,074 )
2020	2020	UNIVERSITY OF MONTANA	32 CAMPUS DR MAIN HALL	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	000	5	7/6/2020	COMPETING CONTINUATION	$293,074
														Subtotal = $293,074

Issue Date FY: 2019 ( Subtotal = $286,375 )
2019	2019	UNIVERSITY OF MONTANA	32 CAMPUS DR MAIN HALL	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	002	4	8/5/2019	NON-COMPETING CONTINUATION	$286,375
2019	2018	UNIVERSITY OF MONTANA	32 CAMPUS DR MAIN HALL	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	001	3	1/15/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$140,638
2019	2017	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Biomedical Research and Research Training	000	2	1/15/2019	NON-COMPETING CONTINUATION	-$140,638
														Subtotal = $286,375

Issue Date FY: 2018 ( Subtotal = $286,375 )
2018	2018	UNIVERSITY OF MONTANA	32 CAMPUS DR MAIN HALL	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	000	3	8/30/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$286,375
2018	2017	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Biomedical Research and Research Training	001	2	8/31/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $286,375

Issue Date FY: 2017 ( Subtotal = $298,699 )
2017	2017	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Biomedical Research and Research Training	000	2	7/21/2017	NON-COMPETING CONTINUATION	$298,699
														Subtotal = $298,699

Issue Date FY: 2016 ( Subtotal = $298,699 )
2016	2016	UNIVERSITY OF TEXAS HEALTH SCIENCE CTR AT SAN ANTONIO	7703 FLOYD CURL DRIVE	SAN ANTONIO	TX	78229	BEXAR	USA	Biomedical Research and Research Training	000	1	7/29/2016	NEW	$298,699
														Subtotal = $298,699

Grand Total All Awards = $2,918,669

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Continued Development and Maintenance of the UltraScan Software

Award Number: R01GM120600

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2016

PERIOD OF PERFORMANCE END DATE: 09/16/2024

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