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Investigating the molecular mechanism and function of mitochondrial tethering

Award Number: R01GM120303
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2017
PERIOD OF PERFORMANCE END DATE: 02/28/2026

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Investigating the molecular mechanism and function of mitochondrial tethering - Project Summary We are interested in the dynamic interplay between the intracellular distribution of mitochondria and cellular function. Mitochondria are important not only for cellular energy production but also play critical roles in cell cycle progression, differentiation, immune responses, lipid and calcium homeostasis, and apoptotic cell death. These diverse roles are intimately connected to mitochondrial shape and cellular position. Thus, it is not surprising aberrant mitochondrial architecture has been implicated in an ever-increasing number of diseases. It is well appreciated that mitochondrial division, fusion, and motility all contribute to the overall distribution of mitochondria within a cell. However, the critical contributions of actively tethering the organelle to specific cellular sites and structures, including other organelles, are becoming increasingly evident. While tethering plays a critical role in mitochondrial positioning, interorganelle contact, and, consequently, cellular function in cells from yeast to neurons, the molecular mechanisms and regulation are poorly understood. In the aims of this grant, we will address this deficit by using a mitochondria-ER-cortex tether in yeast as a model to understand the mechanism and regulation of mitochondrial tethers and the multifunctional mitochondrial membrane contact sites they create. The proposed work will address the exciting and unexpected impacts mitochondrial tethers have on cellular organization and function. The goals are to uncover fundamental mechanisms used by mitochondrial tethers to position mitochondria and form interorganelle contacts and elucidate the functional and physiological consequences of these activities. In doing so, this work will provide insight into novel therapeutic strategies for a range of human disease conditions in which the manipulation of the position and the contacts made by mitochondria can be used to positively influence cellular health and homeostasis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $288,473 )
2025	2025	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Biomedical Research and Research Training	000	9	2/20/2025	NON-COMPETING CONTINUATION	$288,473
														Subtotal = $288,473

Issue Date FY: 2024 ( Subtotal = $320,958 )
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Biomedical Research and Research Training	000	8	1/30/2024	NON-COMPETING CONTINUATION	$288,862
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Biomedical Research and Research Training	001	8	7/23/2024	NON-COMPETING CONTINUATION	$32,096
														Subtotal = $320,958

Issue Date FY: 2023 ( Subtotal = $372,802 )
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Biomedical Research and Research Training	002	7	2/7/2023	NON-COMPETING CONTINUATION	$321,370
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Biomedical Research and Research Training	003	7	5/17/2023	SUPPLEMENT FOR EXPANSION	$51,432
2023	2022	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Biomedical Research and Research Training	001	6	1/26/2023	COMPETING CONTINUATION	$5
2023	2021	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Biomedical Research and Research Training	000	5	1/26/2023	NON-COMPETING CONTINUATION	-$5
														Subtotal = $372,802

Issue Date FY: 2022 ( Subtotal = $337,234 )
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Biomedical Research and Research Training	001	6	2/25/2022	COMPETING CONTINUATION	$337,234
2022	2021	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Biomedical Research and Research Training	000	5	2/17/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $337,234

Issue Date FY: 2021 ( Subtotal = $294,228 )
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Biomedical Research and Research Training	000	5	2/18/2021	NON-COMPETING CONTINUATION	$294,228
														Subtotal = $294,228

Issue Date FY: 2020 ( Subtotal = $294,982 )
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Biomedical Research and Research Training	000	4	2/21/2020	NON-COMPETING CONTINUATION	$294,982
														Subtotal = $294,982

Issue Date FY: 2019 ( Subtotal = $339,701 )
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST EVANSTON	EVANSTON	IL	60208	COOK	USA	Biomedical Research and Research Training	000	3	2/21/2019	NON-COMPETING CONTINUATION	$295,701
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST EVANSTON	EVANSTON	IL	60208	COOK	USA	Biomedical Research and Research Training	001	3	8/21/2019	SUPPLEMENT FOR EXPANSION	$44,000
														Subtotal = $339,701

Issue Date FY: 2018 ( Subtotal = $296,385 )
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST EVANSTON	EVANSTON	IL	60208	COOK	USA	Biomedical Research and Research Training	001	2	5/15/2018	NON-COMPETING CONTINUATION	$29,639
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST EVANSTON	EVANSTON	IL	60208	COOK	USA	Biomedical Research and Research Training	000	2	2/8/2018	NON-COMPETING CONTINUATION	$266,746
														Subtotal = $296,385

Issue Date FY: 2017 ( Subtotal = $288,768 )
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST EVANSTON	EVANSTON	IL	60208	COOK	USA	Biomedical Research and Research Training	000	1	3/1/2017	NEW	$288,768
														Subtotal = $288,768

Grand Total All Awards = $2,833,531

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Investigating the molecular mechanism and function of mitochondrial tethering

Award Number: R01GM120303

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2017

PERIOD OF PERFORMANCE END DATE: 02/28/2026

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