Tuesday, April 16, 2024 4/16/2024

Mechanism of Microtubule Dynamics Regulation by Kinesins

Award Number: R01GM113164
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

Kinesins are eukaryotic cytoskeletal proteins best known for their motile activity, but they are also important regulators of microtubule dynamics, the ability of the microtubule polymer to grow or shrink. This project seeks to establish the molecular mechanism of microtubule dynamics regulation by members of the kinesin superfamily. Regulation of microtubule dynamics by these kinesins play important roles in a variety of cell processes such as mitosis, cytokinesis, neural development and control of cilia and centriole length, but the mechanisms by which these kinesins stabilize or destabilize microtubules is still not clear. It is not known how different kinesin may be adapted for seemingly different functionalities or whether they share common mechanisms. To address this issue we propose to conduct comparative structural and functional analysis of several kinesins with distinct functionalities: the microtubule depolymerase KLP10A (kinesin-13), the motile and microtubule stabilizers KIF14 (kinesin-3) and EG5 (kinesin- 5) and the archetypical motile kinesin KIF5B (kinesin-1). The proposal is divided in four aims. The first two aims test the hypothesis based on our recent work that the same ATPase related confomational changes occurring in the motor domain of kinesin-1s are adapted in kinesin-13s to depolymerize microtubules. The second aim investigates the mechanism by which EG5 promotes microtubule polymerization and inhibits depolymerization. The fourth aim uses cryo- em structural analysis to guide the development and optimization of KIF14 specific drugs for research and potentially clinical use.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $576,213 )
2023	2023	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	000	11	7/20/2023	COMPETING CONTINUATION	$576,213
														Subtotal = $576,213

Issue Date FY: 2022 ( Subtotal = $442,550 )
2022	2022	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	001	10	8/2/2022	NON-COMPETING CONTINUATION	$44,254
2022	2022	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	000	10	1/14/2022	NON-COMPETING CONTINUATION	$398,296
														Subtotal = $442,550

Issue Date FY: 2021 ( Subtotal = $442,550 )
2021	2021	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	000	9	1/25/2021	NON-COMPETING CONTINUATION	$398,297
2021	2021	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	001	9	2/23/2021	NON-COMPETING CONTINUATION	$44,253
														Subtotal = $442,550

Issue Date FY: 2020 ( Subtotal = $442,550 )
2020	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	000	8	1/30/2020	NON-COMPETING CONTINUATION	$398,296
2020	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	001	8	3/10/2020	NON-COMPETING CONTINUATION	$44,254
2020	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	002	7	4/24/2020	COMPETING CONTINUATION	$1,721
2020	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	003	6	4/24/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$1,721
														Subtotal = $442,550

Issue Date FY: 2019 ( Subtotal = $442,550 )
2019	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	004	7	4/4/2019	COMPETING CONTINUATION	$0
2019	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	003	7	2/25/2019	COMPETING CONTINUATION	$442,550
2019	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	007	7	6/12/2019	COMPETING CONTINUATION	$825
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	002	6	2/8/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$66,925
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	008	6	6/12/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$825
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	006	6	5/9/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$30,629
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	005	5	5/9/2019	SUPPLEMENT FOR EXPANSION	-$30,629
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	001	5	2/7/2019	SUPPLEMENT FOR EXPANSION	-$26,044
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	000	5	2/6/2019	NON-COMPETING CONTINUATION	-$40,881
														Subtotal = $442,550

Issue Date FY: 2018 ( Subtotal = $458,924 )
2018	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	000	5	2/17/2018	NON-COMPETING CONTINUATION	$361,237
2018	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	001	5	5/1/2018	NON-COMPETING CONTINUATION	$40,139
2018	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	002	5	9/12/2018	SUPPLEMENT FOR EXPANSION	$57,548
														Subtotal = $458,924

Issue Date FY: 2017 ( Subtotal = $404,140 )
2017	2017	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	001	4	8/5/2017	NON-COMPETING CONTINUATION	$40,414
2017	2017	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Biomedical Research and Research Training	000	4	2/16/2017	NON-COMPETING CONTINUATION	$363,726
														Subtotal = $404,140

Issue Date FY: 2016 ( Subtotal = $404,140 )
2016	2016	ALBERT EINSTEIN COLLEGE OF MEDICINE INC	111 E 210TH ST	BRONX	NY	10467	BRONX	USA	Biomedical Research and Research Training	002	3	2/22/2016	NON-COMPETING CONTINUATION	$404,140
2016	2015	ALBERT EINSTEIN COLLEGE OF MEDICINE INC	111 E 210TH ST	BRONX	NY	10467	BRONX	USA	Biomedical Research and Research Training	001	2	12/4/2015	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$202,070
2016	2015	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Biomedical Research and Research Training	000	1	12/3/2015	NEW	-$202,070
														Subtotal = $404,140

Issue Date FY: 2015 ( Subtotal = $404,140 )
2015	2015	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Biomedical Research and Research Training	000	1	2/27/2015	NEW	$404,140
														Subtotal = $404,140

Grand Total All Awards = $4,017,757

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Mechanism of Microtubule Dynamics Regulation by Kinesins

Award Number: R01GM113164

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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