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Developmental disruption of brain tissue oxygen regulation and deficiency of learning after neonatal anesthesia exposure

Award Number: R01GM112715
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2016
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Developmental disruption of brain tissue oxygen regulation and deficiency of learning after neonatal anesthesia exposure - We are seeking supplemental funding to purchase an advanced electrophysiological recording system for our project. This project studies the effects of general anesthesia on neuronal activity and oxygen levels in the cerebral cortex, requiring continuous recording via chronically implanted electrodes. Our existing system is old and increasingly unreliable, and moreover, it is insufficient for our experiments, especially when multiple kits are born simultaneously. A new system will allow us to monitor more animals simultaneously and offer improved design and signal quality. The updated system will reduce experimental time, ensure cleaner data, and enable better comparisons between oxygen levels and electrophysiological signals. Acquiring the new Neuralynx system will enhance our recording capabilities, benefiting our current and future research. We seek additional funding to procure this system, confident in its substantial contributions to our work.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $416,798 )
2024	2024	NORTHSHORE UNIVERSITY HEALTHSYSTEM	SUITE 301	EVANSTON	IL	60201	COOK	USA	Biomedical Research and Research Training	001	9	9/10/2024	SUPPLEMENT FOR EXPANSION	$70,648
2024	2024	NORTHSHORE UNIVERSITY HEALTHSYSTEM	SUITE 301	EVANSTON	IL	60201	COOK	USA	Biomedical Research and Research Training	000	9	8/14/2024	NON-COMPETING CONTINUATION	$346,150
														Subtotal = $416,798

Issue Date FY: 2023 ( Subtotal = $436,017 )
2023	2023	NORTHSHORE UNIVERSITY HEALTHSYSTEM	SUITE 301	EVANSTON	IL	60201	COOK	USA	Biomedical Research and Research Training	000	7	5/24/2023	SUPPLEMENT FOR EXPANSION	$89,867
2023	2023	NORTHSHORE UNIVERSITY HEALTHSYSTEM	SUITE 301	EVANSTON	IL	60201	COOK	USA	Biomedical Research and Research Training	001	8	8/8/2023	NON-COMPETING CONTINUATION	$346,150
														Subtotal = $436,017

Issue Date FY: 2022 ( Subtotal = $346,150 )
2022	2022	NORTHSHORE UNIVERSITY HEALTHSYSTEM	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Biomedical Research and Research Training	000	7	8/19/2022	NON-COMPETING CONTINUATION	$346,150
2022	2021	NORTHSHORE UNIVERSITY HEALTHSYSTEM	SUITE 301	EVANSTON	IL	60201	COOK	USA	Biomedical Research and Research Training	002	6	8/23/2022	COMPETING CONTINUATION	$123,034
2022	2020	NORTHSHORE UNIVERSITY HEALTHSYSTEM	SUITE 301	EVANSTON	IL	60201	COOK	USA	Biomedical Research and Research Training	001	5	8/23/2022	NON-COMPETING CONTINUATION	-$123,034
														Subtotal = $346,150

Issue Date FY: 2021 ( Subtotal = $291,698 )
2021	2021	NORTHSHORE UNIVERSITY HEALTHSYSTEM	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Biomedical Research and Research Training	001	6	9/16/2021	COMPETING CONTINUATION	$291,698
2021	2021	NORTHSHORE UNIVERSITY HEALTHSYSTEM	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Biomedical Research and Research Training	002	6	9/29/2021	COMPETING CONTINUATION	$0
2021	2020	NORTHSHORE UNIVERSITY HEALTHSYSTEM	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Biomedical Research and Research Training	000	5	9/15/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $291,698

Issue Date FY: 2020 ( Subtotal = $298,045 )
2020	2020	NORTHSHORE UNIVERSITY HEALTHSYSTEM	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Biomedical Research and Research Training	000	5	5/20/2020	NON-COMPETING CONTINUATION	$298,045
														Subtotal = $298,045

Issue Date FY: 2019 ( Subtotal = $298,098 )
2019	2019	NORTHSHORE UNIVERSITY HEALTHSYSTEM	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Biomedical Research and Research Training	000	4	5/17/2019	NON-COMPETING CONTINUATION	$298,098
														Subtotal = $298,098

Issue Date FY: 2018 ( Subtotal = $346,610 )
2018	2018	NORTHSHORE UNIVERSITY HEALTHSYSTEM	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Biomedical Research and Research Training	001	3	8/3/2018	SUPPLEMENT FOR EXPANSION	$48,414
2018	2018	NORTHSHORE UNIVERSITY HEALTHSYSTEM	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Biomedical Research and Research Training	000	3	5/17/2018	NON-COMPETING CONTINUATION	$298,196
														Subtotal = $346,610

Issue Date FY: 2017 ( Subtotal = $294,362 )
2017	2017	NORTHSHORE UNIVERSITY HEALTHSYSTEM	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Biomedical Research and Research Training	001	2	8/14/2017	NON-COMPETING CONTINUATION	$29,437
2017	2017	NORTHSHORE UNIVERSITY HEALTHSYSTEM	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Biomedical Research and Research Training	000	2	5/16/2017	NON-COMPETING CONTINUATION	$264,925
														Subtotal = $294,362

Issue Date FY: 2016 ( Subtotal = $305,273 )
2016	2016	NORTHSHORE UNIVERSITY HEALTHSYSTEM	1301 CENTRAL STREET	EVANSTON	IL	60201	COOK	USA	Biomedical Research and Research Training	000	1	8/11/2016	NEW	$305,273
														Subtotal = $305,273

Grand Total All Awards = $3,033,051

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Developmental disruption of brain tissue oxygen regulation and deficiency of learning after neonatal anesthesia exposure

Award Number: R01GM112715

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2016

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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