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Horizontal gene transfer as a source of evolutionary innovation in metazoans

Award Number: R01GM111917
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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PROJECT SUMMARY The role of horizontal gene transfer in eukaryotic evolution remains one of the most hotly debated topics in evolutionary biology. While several claims of massive horizontal transfer in eukaryotes have been disproven in recent years, rotifers of the class Bdelloidea, with 8-10% of their genes coming from non-metazoan sources, remain the only metazoan taxon that withstands the scrutiny. Our work has confirmed the presence and functionality of a non-canonical system of epigenetic modification of bacterial origin, capable of introducing bacterial modification marks into eukaryotic DNA. Further, we identified genes of foreign origin that may serve as potential sources of diversification in the expanded system of secondary metabolism. Finally, with desiccation no longer suspected as the leading reason defining the unusual ability of bdelloids to capture foreign genetic material, we are investigating novel types of giant transposable elements that may have participated in gene transfer. These lines of investigation will be pursued and combined to uncover the complex evolutionary history of foreign gene acquisition and diversification in this exceptional metazoan taxon, and to better understand how the barriers preventing such acquisition in most eukaryotic taxa can occasionally be broken in selected branches of the metazoan tree of life. !


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $314,253 )
2024	2024	THE MARINE BIOLOGICAL LABORATORY	7 M B L ST	WOODS HOLE	MA	02543	BARNSTABLE	USA	Biomedical Research and Research Training	000	11	3/25/2024	NON-COMPETING CONTINUATION	$314,253
														Subtotal = $314,253

Issue Date FY: 2023 ( Subtotal = $376,455 )
2023	2023	THE MARINE BIOLOGICAL LABORATORY	7 M B L ST	WOODS HOLE	MA	02543	BARNSTABLE	USA	Biomedical Research and Research Training	000	10	4/14/2023	NON-COMPETING CONTINUATION	$346,250
2023	2023	THE MARINE BIOLOGICAL LABORATORY	7 M B L ST	WOODS HOLE	MA	02543	BARNSTABLE	USA	Biomedical Research and Research Training	001	10	7/28/2023	SUPPLEMENT FOR EXPANSION	$30,205
														Subtotal = $376,455

Issue Date FY: 2022 ( Subtotal = $354,902 )
2022	2022	THE MARINE BIOLOGICAL LABORATORY	7 M B L ST	WOODS HOLE	MA	02543	BARNSTABLE	USA	Biomedical Research and Research Training	001	9	8/1/2022	COMPETING CONTINUATION	$345,628
2022	2021	THE MARINE BIOLOGICAL LABORATORY	7 M B L ST	WOODS HOLE	MA	02543	BARNSTABLE	USA	Biomedical Research and Research Training	000	8	7/22/2022	NON-COMPETING CONTINUATION	$0
2022	2017	THE MARINE BIOLOGICAL LABORATORY	7 M B L ST	WOODS HOLE	MA	02543	BARNSTABLE	USA	Biomedical Research and Research Training	002	4	9/26/2022	NON-COMPETING CONTINUATION	$9,274
														Subtotal = $354,902

Issue Date FY: 2021 ( Subtotal = $328,000 )
2021	2021	MARINE BIOLOGICAL LABORATORY, THE	7 M B L ST	WOODS HOLE	MA	02543	BARNSTABLE	USA	Biomedical Research and Research Training	000	8	6/18/2021	NON-COMPETING CONTINUATION	$328,000
														Subtotal = $328,000

Issue Date FY: 2020 ( Subtotal = $328,000 )
2020	2020	MARINE BIOLOGICAL LABORATORY, THE	7 M B L ST	WOODS HOLE	MA	02543	BARNSTABLE	USA	Biomedical Research and Research Training	000	7	6/9/2020	NON-COMPETING CONTINUATION	$328,000
2020	2018	MARINE BIOLOGICAL LABORATORY, THE	7 M B L ST	WOODS HOLE	MA	02543	BARNSTABLE	USA	Biomedical Research and Research Training	002	5	9/5/2020	COMPETING CONTINUATION	$583
2020	2017	MARINE BIOLOGICAL LABORATORY, THE	7 M B L ST	WOODS HOLE	MA	02543	BARNSTABLE	USA	Biomedical Research and Research Training	001	4	9/5/2020	NON-COMPETING CONTINUATION	-$583
														Subtotal = $328,000

Issue Date FY: 2019 ( Subtotal = $455,133 )
2019	2019	MARINE BIOLOGICAL LABORATORY, THE	7 M B L ST	WOODS HOLE	MA	02543	BARNSTABLE	USA	Biomedical Research and Research Training	002	6	6/5/2019	NON-COMPETING CONTINUATION	$328,000
2019	2019	MARINE BIOLOGICAL LABORATORY, THE	7 M B L ST	WOODS HOLE	MA	02543	BARNSTABLE	USA	Biomedical Research and Research Training	003	6	8/1/2019	SUPPLEMENT FOR EXPANSION	$127,133
2019	2018	MARINE BIOLOGICAL LABORATORY, THE	7 M B L ST	WOODS HOLE	MA	02543	BARNSTABLE	USA	Biomedical Research and Research Training	001	5	2/15/2019	COMPETING CONTINUATION	$9,274
2019	2017	MARINE BIOLOGICAL LABORATORY, THE	7 M B L ST	WOODS HOLE	MA	02543	BARNSTABLE	USA	Biomedical Research and Research Training	000	4	2/15/2019	NON-COMPETING CONTINUATION	-$9,274
														Subtotal = $455,133

Issue Date FY: 2018 ( Subtotal = $328,000 )
2018	2018	MARINE BIOLOGICAL LABORATORY, THE	7 M B L ST	WOODS HOLE	MA	02543	BARNSTABLE	USA	Biomedical Research and Research Training	000	5	6/26/2018	COMPETING CONTINUATION	$328,000
														Subtotal = $328,000

Issue Date FY: 2017 ( Subtotal = $304,950 )
2017	2017	MARINE BIOLOGICAL LABORATORY, THE	7 M B L ST	WOODS HOLE	MA	02543	BARNSTABLE	USA	Biomedical Research and Research Training	000	4	6/28/2017	NON-COMPETING CONTINUATION	$304,950
														Subtotal = $304,950

Issue Date FY: 2016 ( Subtotal = $304,950 )
2016	2016	MARINE BIOLOGICAL LABORATORY	7 MBL STREET	WOODS HOLE	MA	02543	BARNSTABLE	USA	Biomedical Research and Research Training	000	3	6/20/2016	NON-COMPETING CONTINUATION	$304,950
														Subtotal = $304,950

Issue Date FY: 2015 ( Subtotal = $302,651 )
2015	2015	MARINE BIOLOGICAL LABORATORY	7 MBL STREET	WOODS HOLE	MA	02543	BARNSTABLE	USA	Biomedical Research and Research Training	000	2	6/9/2015	NON-COMPETING CONTINUATION	$302,651
														Subtotal = $302,651

Issue Date FY: 2014 ( Subtotal = $302,651 )
2014	2014	MARINE BIOLOGICAL LABORATORY	7 MBL STREET	WOODS HOLE	MA	02543	BARNSTABLE	USA	Biomedical Research and Research Training	000	1	7/25/2014	NEW	$302,651
														Subtotal = $302,651

Grand Total All Awards = $3,699,945

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Horizontal gene transfer as a source of evolutionary innovation in metazoans

Award Number: R01GM111917

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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