Monday, June 30, 2025 6/30/2025

The Discovery of Human Peptide Encoding Genes

Award Number: R01GM102491
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/21/2012
PERIOD OF PERFORMANCE END DATE: 06/30/2026

Group Awards By:

View Award Description

The Discovery of Human Peptide Encoding Genes - ABSTRACT Understanding the information contained within the human genome has been a goal of molecular biology and medicine since the identification of DNA. The Human Genome Project cataloged all the protein-coding genes embedded within the genome, but gene-finding algorithms had a blind spot for protein-coding small open reading frames (smORFs). Technological advances over the last decade have led to the discovery of thousands of smORFs in the human genome that encode peptides or small proteins (median length 30 amino acids) collectively referred to as microproteins. The discovery of thousands of previously unknown proteins in the human genome is an exciting opportunity in molecular biology that promises to improve scientific understanding and the ability to discover and develop new medicines. This proposal seeks to answer important questions that have emerged regarding microproteins, including whether microproteins from polycistronic genes are functional (Aim 1), whether biologically active secreted microproteins exist (Aim 2), and, lastly, whether it is possible to use knowledge about the structure and mechanism of microproteins to develop small-molecule probes that can regulate their actives in cells (Aim 3). These questions will be tackled using approaches and reagents developed over the last decade. For example, optimized robust protocols are now available for investigating microprotein-protein interactions together with necessary reagents including antibodies, cell lines, and genetically engineered mice to study these unique genes. This proposal will reveal new functions for microproteins in cells and tissues, identify biologically active secreted microproteins, and identify small molecule probes of microprotein biology. These efforts will increase understanding of the roles of smORFs and microproteins in mammalian genomes and identify secreted microproteins and small molecules that provide a template for converting these foundational discoveries into medicines.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $483,123 )
2025	2025	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	13	6/16/2025	NON-COMPETING CONTINUATION	$483,123
														Subtotal = $483,123

Issue Date FY: 2024 ( Subtotal = $483,123 )
2024	2024	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	12	6/10/2024	NON-COMPETING CONTINUATION	$483,123
														Subtotal = $483,123

Issue Date FY: 2023 ( Subtotal = $483,123 )
2023	2023	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	11	6/26/2023	NON-COMPETING CONTINUATION	$483,123
														Subtotal = $483,123

Issue Date FY: 2022 ( Subtotal = $483,123 )
2022	2022	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	10	9/1/2022	COMPETING CONTINUATION	$483,123
														Subtotal = $483,123

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	9	8/29/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $478,926 )
2020	2020	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	9	4/27/2020	NON-COMPETING CONTINUATION	$478,926
														Subtotal = $478,926

Issue Date FY: 2019 ( Subtotal = $479,130 )
2019	2019	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	8	5/29/2019	NON-COMPETING CONTINUATION	$479,130
														Subtotal = $479,130

Issue Date FY: 2018 ( Subtotal = $549,540 )
2018	2018	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	7	4/25/2018	NON-COMPETING CONTINUATION	$497,589
2018	2018	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	001	7	9/18/2018	SUPPLEMENT FOR EXPANSION	$51,951
														Subtotal = $549,540

Issue Date FY: 2017 ( Subtotal = $490,803 )
2017	2017	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	001	6	8/22/2017	COMPETING CONTINUATION	$490,803
2017	2015	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	5	7/10/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $490,803

Issue Date FY: 2015 ( Subtotal = $428,094 )
2015	2015	SALK INSTITUTE FOR BIOLOGICAL STUDIES	P.O. BOX 85800	SAN DIEGO	CA	92186	SAN DIEGO	USA	Biomedical Research and Research Training	002	5	8/27/2015	NON-COMPETING CONTINUATION	$432,405
2015	2013	SALK INSTITUTE FOR BIOLOGICAL STUDIES	P.O. BOX 85800	SAN DIEGO	CA	92186	SAN DIEGO	USA	Biomedical Research and Research Training	001	3	2/23/2015	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$33,453
2015	2013	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Biomedical Research and Research Training	000	2	2/23/2015	NON-COMPETING CONTINUATION	$29,142
														Subtotal = $428,094

Issue Date FY: 2014 ( Subtotal = $437,946 )
2014	2014	SALK INSTITUTE FOR BIOLOGICAL STUDIES	P.O. BOX 85800	SAN DIEGO	CA	92186	SAN DIEGO	USA	Biomedical Research and Research Training	002	4	8/21/2014	NON-COMPETING CONTINUATION	$432,405
2014	2013	SALK INSTITUTE FOR BIOLOGICAL STUDIES	P.O. BOX 85800	SAN DIEGO	CA	92186	SAN DIEGO	USA	Biomedical Research and Research Training	001	3	8/6/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$42,998
2014	2013	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Biomedical Research and Research Training	000	2	8/5/2014	NON-COMPETING CONTINUATION	-$37,457
														Subtotal = $437,946

Issue Date FY: 2013 ( Subtotal = $360,689 )
2013	2013	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Biomedical Research and Research Training	000	2	8/26/2013	NON-COMPETING CONTINUATION	$360,689
														Subtotal = $360,689

Issue Date FY: 2012 ( Subtotal = $387,730 )
2012	2012	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Biomedical Research and Research Training	000	1	9/21/2012	NEW	$387,730
														Subtotal = $387,730

Grand Total All Awards = $5,545,350

Top

All Categories

About

Search

Reports

Data Submission

Award Information

The Discovery of Human Peptide Encoding Genes

Award Number: R01GM102491

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/21/2012

PERIOD OF PERFORMANCE END DATE: 06/30/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer