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Heterochromatin and Toxic YChromosomes

Award Number: R01GM101255
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Heterochromatin and Toxic YChromosomes - Y chromosomes of many organisms contain a large number of transposable elements (TEs), which are transcriptionally constrained by repressive chromatin marks. When relieved of these epigenetic modifications, many TEs can readily move from one genomic location to another (toxic Y chromosomes). Yet evolutionarily young Y chromosomes still contain a large number of essential genes that are actively transcribed, and competition between the opposing mechanisms of heterochromatin formation and active transcription can result in incomplete silencing of TEs on evolving Y chromosomes. Our proposal aims to characterize epigenetic conflicts between host-specific genes and selfish genetic elements on evolving Y chromosomes at various stages of degeneration, whose resolution may select for adaptive degeneration of the Y. The accumulation of repetitive elements on the Y chromosome appears to be universal during sex chromosome evolution. We will take advantage of evolving neo-Y chromosomes in Drosophila with varying levels of degeneration, to catalog toxicity of Y chromosomes using expression profiling and chromatin analysis. We will link epigenetic and expression profiles across neo-Y chromosomes that differ in gene and repeat density, to identify whether active transcription of genes on neo-Y chromosomes results in incomplete silencing of TEs. We will establish whether toxic Y chromosomes incur a fitness cost on males, by forming a mutational burden and reducing male longevity, as suggested by our preliminary work. Integrating our results across aims will provide a full picture of how the toxicity of the Y chromosome changes over time, and how epigenetic conflicts between host genes and selfish elements may be resolved.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $346,125 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	11	1/22/2025	NON-COMPETING CONTINUATION	$346,125
														Subtotal = $346,125

Issue Date FY: 2024 ( Subtotal = $384,842 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	003	10	6/25/2024	NON-COMPETING CONTINUATION	$38,483
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	002	10	3/6/2024	NON-COMPETING CONTINUATION	$346,359
2024	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	9	3/5/2024	COMPETING CONTINUATION	$97,642
2024	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	8	3/5/2024	NON-COMPETING CONTINUATION	-$97,642
														Subtotal = $384,842

Issue Date FY: 2023 ( Subtotal = $384,842 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	002	9	3/31/2023	COMPETING CONTINUATION	$384,842
2023	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	8	3/30/2023	NON-COMPETING CONTINUATION	$0
2023	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	8	3/3/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $384,842

Issue Date FY: 2022 ( Subtotal = $419,173 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	8	7/27/2022	NON-COMPETING CONTINUATION	$41,918
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	8	1/17/2022	NON-COMPETING CONTINUATION	$377,255
														Subtotal = $419,173

Issue Date FY: 2021 ( Subtotal = $428,797 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	7	2/17/2021	NON-COMPETING CONTINUATION	$42,880
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	7	1/20/2021	NON-COMPETING CONTINUATION	$385,917
														Subtotal = $428,797

Issue Date FY: 2020 ( Subtotal = $438,421 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	6	3/11/2020	NON-COMPETING CONTINUATION	$43,843
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	6	12/24/2019	NON-COMPETING CONTINUATION	$394,578
														Subtotal = $438,421

Issue Date FY: 2019 ( Subtotal = $438,421 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	000	5	1/23/2019	COMPETING CONTINUATION	$438,421
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	002	5	6/7/2019	COMPETING CONTINUATION	$20,522
2019	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	4	6/7/2019	NON-COMPETING CONTINUATION	-$20,522
														Subtotal = $438,421

Issue Date FY: 2018 ( Subtotal = $420,425 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	001	4	6/19/2018	NON-COMPETING CONTINUATION	$42,043
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	000	4	1/11/2018	NON-COMPETING CONTINUATION	$378,382
														Subtotal = $420,425

Issue Date FY: 2017 ( Subtotal = $420,425 )
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	001	3	6/13/2017	NON-COMPETING CONTINUATION	$42,044
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	000	3	12/12/2016	NON-COMPETING CONTINUATION	$378,381
														Subtotal = $420,425

Issue Date FY: 2016 ( Subtotal = $420,425 )
2016	2016	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	000	2	12/17/2015	NON-COMPETING CONTINUATION	$378,381
2016	2016	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	001	2	3/3/2016	NON-COMPETING CONTINUATION	$42,044
														Subtotal = $420,425

Issue Date FY: 2015 ( Subtotal = $419,771 )
2015	2015	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	000	1	12/29/2014	NEW	$419,771
														Subtotal = $419,771

Grand Total All Awards = $4,521,667

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Heterochromatin and Toxic YChromosomes

Award Number: R01GM101255

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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