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The role of platelets in tumor growth, wound healing and other angiogenesis disea

Award Number: R01GM093050
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2010
PERIOD OF PERFORMANCE END DATE: 02/28/2015

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The role of platelets in tumor growth, wound healing and other angiogenesis disea - DESCRIPTION (provided by applicant): The role of platelets in tumor growth, wound healing and other angiogenesis disease states The role of platelets in angiogenesis has been appreciated in the past both clinically and pre- clinically. We have recently published evidence that platelets actively sequester angiogenesis stimulators as well as inhibitors, and that there may be a higher organization of these opposing roles within platelet. This higher organization may facilitate the ability of platelets to modify angiogenesis in many angiogenesis-dependent disorders such as wound healing, atherosclerosis, tumor growth, macular degeneration and many others. Since the ability of platelets to enhance wound healing is restricted to intact platelets and does not extend to previously frozen platelets, the process most likely involves a reciprocal interaction between live, fully functional platelet and the wound microenvironment. Unlike other cells, platelets are destroyed by freezing. This proposal will a) characterize the molecular and cellular mechanisms by which platelets sequester and store angiogenesis regulators (Specific Aim 1); b) evaluate the mechanisms of release of these angiogenesis regulators from platelets (Specific Aim 2); c) test the potential therapeutic relevance of strategies designed to selectively release stimulators or inhibitors of angiogenesis from platelets in wound and tumor models (Specific Aim 3). The goal of these studies will be to provide a framework for development of novel targeted therapies for improvement of wound care, as well as for inhibition of tumor growth. It is expected that many agents that modify platelet function, secretion of proteins from platelets, and/or platelet adhesion will be applicable for management pathologic angiogenesis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2014 ( Subtotal = -$3,078 )
2014	2013	GENESYS RESEARCH INSTITUTE INC	77 WARREN STREET	BOSTON	MA	02135	SUFFOLK	USA	Biomedical Research and Research Training	000	5	3/26/2014	NON-COMPETING CONTINUATION	-$166,911
2014	2013	TUFTS MEDICAL CENTER	750 WASHINGTON STREET	BOSTON	MA	02111	SUFFOLK	USA	Biomedical Research and Research Training	001	6	3/28/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$163,833
														Subtotal = -$3,078

Issue Date FY: 2013 ( Subtotal = $310,081 )
2013	2013	TUFTS MEDICAL CENTER	750 WASHINGTON STREET	BOSTON	MA	02111	SUFFOLK	USA	Biomedical Research and Research Training	002	6	3/28/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$163,833
2013	2013	GENESYS RESEARCH INSTITUTE INC	77 Warren Street	BOSTON	MA	02135	SUFFOLK	USA	Biomedical Research and Research Training	001	5	3/26/2014	NON-COMPETING CONTINUATION	-$166,911
2013	2013	GENESYS RESEARCH INSTITUTE INC	77 Warren Street	BOSTON	MA	02135	SUFFOLK	USA	Biomedical Research and Research Training	000	5	8/30/2013	NON-COMPETING CONTINUATION	$313,159
														Subtotal = $310,081

Issue Date FY: 2012 ( Subtotal = $313,263 )
2012	2012	GENESYS RESEARCH INSTITUTE INC	77 Warren Street	BOSTON	MA	02135	SUFFOLK	USA	Biomedical Research and Research Training	002	4	8/30/2012	NON-COMPETING CONTINUATION	$324,517
2012	2011	GENESYS RESEARCH INSTITUTE INC	77 Warren Street	BOSTON	MA	02135	SUFFOLK	USA	Biomedical Research and Research Training	001	3	8/29/2012	NON-COMPETING CONTINUATION	-$5,599
2012	2010	GENESYS RESEARCH INSTITUTE INC	77 Warren Street	BOSTON	MA	02135	SUFFOLK	USA	Biomedical Research and Research Training	000	2	8/28/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$5,655
														Subtotal = $313,263

Issue Date FY: 2011 ( Subtotal = $330,115 )
2011	2011	GENESYS RESEARCH INSTITUTE INC	77 Warren Street	BOSTON	MA	02135	SUFFOLK	USA	Biomedical Research and Research Training	002	3	8/26/2011	NON-COMPETING CONTINUATION	$330,116
2011	2010	CARITAS ST ELIZABETH`S MEDICAL CENTER OF BOSTON	736 CAMBRIDGE ST, BOX OLH-6BD	BOSTON	MA	02135	SUFFOLK	USA	Biomedical Research and Research Training	001	1	8/10/2011	NEW	-$333,449
2011	2010	GENESYS RESEARCH INSTITUTE INC	77 Warren Street	BOSTON	MA	02135	SUFFOLK	USA	Biomedical Research and Research Training	000	2	8/10/2011	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$333,448
														Subtotal = $330,115

Issue Date FY: 2010 ( Subtotal = $333,450 )
2010	2010	CARITAS ST ELIZABETH`S MEDICAL CENTER OF BOSTON	736 CAMBRIDGE ST, BOX OLH-6BD	BOSTON	MA	02135	SUFFOLK	USA	Biomedical Research and Research Training	000	1	9/28/2010	NEW	$333,450
														Subtotal = $333,450

Grand Total All Awards = $1,283,831

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The role of platelets in tumor growth, wound healing and other angiogenesis disea

Award Number: R01GM093050

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2010

PERIOD OF PERFORMANCE END DATE: 02/28/2015

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