Wednesday, July 16, 2025 7/16/2025

Integrated Resource for Nucleic Acid Structures

Award Number: R01GM085328
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/10/2010
PERIOD OF PERFORMANCE END DATE: 08/31/2024

Group Awards By:

View Award Description

Integrated Resource for Nucleic Acid Structures - SUMMARY We are analyzing, annotating, organizing, and integrating nucleic acid 3D structural data with sequence and functional data and delivering it to biomedical researchers. The significance of the proposal lies in the prominent roles of nucleic acids in a host of cellular and physiological processes, mediated by interaction with specific DNA- and RNA-binding proteins. DNA encodes genetic information and takes part in replication, recombination, transcription, and repair. RNA transmits genetic information and takes part in all aspects of gene regulation. RNA is also the key component of the ribosome, the universal protein-making nano-machine and an important target for drug design. RNA/DNA hybrids occur in many biological contexts, including transcription complexes, origins of replication, and the widely heralded CRISPR-CAS systems for precision editing of genes (Wright 2016). They form unique structures different from double helical RNA or DNA. High throughput methods have catalogued many new non-coding RNAs (ncRNAs) and RNA-binding proteins lacking previously known RNA-binding domains. The Specific Aims of this proposal are: 1) Create more complete annotations for all nucleic acid 3D structures, 2) create new annotations for nucleic acid-protein complexes, and 3) create a Nucleic Acid Knowledge Base (NAKB) that allows for both deep and wide searching of information about nucleic acid sequences and structures. Under these aims, we will analyze and annotate all types of nucleic acid 3D structures, including DNA, RNA, and DNA/RNA hybrids, and improve our ability to predict 3D structures from sequence. The NAKB resource will provide new search capabilities, enhanced reports, and link-outs to external data, features and tools. The proposed enhancements will greatly improve our abilities to search and visualize existing data on nucleic acid sequence and structural features and will further enrich the user experience and enable data discovery. The innovation of the proposal is the creation of a unified resource for all nucleic acid 3D structures.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $371,781 )
2023	2023	BOWLING GREEN STATE UNIVERSITY	1851 N RESEARCH DR	BOWLING GREEN	OH	43403	WOOD	USA	Biomedical Research and Research Training	000	12	8/29/2023	NON-COMPETING CONTINUATION	$371,781
														Subtotal = $371,781

Issue Date FY: 2022 ( Subtotal = $371,781 )
2022	2022	BOWLING GREEN STATE UNIVERSITY	319 ADMINISTRATION BLDG	BOWLING GREEN	OH	43403	WOOD	USA	Biomedical Research and Research Training	000	11	9/2/2022	NON-COMPETING CONTINUATION	$371,781
														Subtotal = $371,781

Issue Date FY: 2021 ( Subtotal = $371,781 )
2021	2021	BOWLING GREEN STATE UNIVERSITY	319 ADMINISTRATION BLDG	BOWLING GREEN	OH	43403	WOOD	USA	Biomedical Research and Research Training	003	10	8/23/2021	NON-COMPETING CONTINUATION	$371,781
2021	2020	BOWLING GREEN STATE UNIVERSITY	319 ADMINISTRATION BLDG	BOWLING GREEN	OH	43403	WOOD	USA	Biomedical Research and Research Training	000	9	3/10/2021	COMPETING CONTINUATION	$0
2021	2020	BOWLING GREEN STATE UNIVERSITY	319 ADMINISTRATION BLDG	BOWLING GREEN	OH	43403	WOOD	USA	Biomedical Research and Research Training	002	9	6/13/2021	COMPETING CONTINUATION	$18,225
2021	2017	BOWLING GREEN STATE UNIVERSITY	319 ADMINISTRATION BLDG	BOWLING GREEN	OH	43403	WOOD	USA	Biomedical Research and Research Training	001	8	6/13/2021	NON-COMPETING CONTINUATION	-$18,225
														Subtotal = $371,781

Issue Date FY: 2020 ( Subtotal = $382,370 )
2020	2020	BOWLING GREEN STATE UNIVERSITY	319 ADMINISTRATION BLDG	BOWLING GREEN	OH	43403	WOOD	USA	Biomedical Research and Research Training	000	9	9/23/2020	COMPETING CONTINUATION	$382,370
														Subtotal = $382,370

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	BOWLING GREEN STATE UNIVERSITY	319 ADMINISTRATION BLDG	BOWLING GREEN	OH	43403	WOOD	USA	Biomedical Research and Research Training	000	8	9/23/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $315,498 )
2017	2017	BOWLING GREEN STATE UNIVERSITY	319 ADMINISTRATION BLDG	BOWLING GREEN	OH	43403	WOOD	USA	Biomedical Research and Research Training	000	8	8/21/2017	NON-COMPETING CONTINUATION	$315,498
														Subtotal = $315,498

Issue Date FY: 2016 ( Subtotal = $315,498 )
2016	2016	BOWLING GREEN STATE UNIVERSITY	***	BOWLING GREEN	OH	43403	WOOD	USA	Biomedical Research and Research Training	000	7	8/18/2016	NON-COMPETING CONTINUATION	$315,498
														Subtotal = $315,498

Issue Date FY: 2015 ( Subtotal = $315,498 )
2015	2015	BOWLING GREEN STATE UNIVERSITY	***	BOWLING GREEN	OH	43403	WOOD	USA	Biomedical Research and Research Training	000	6	8/31/2015	NON-COMPETING CONTINUATION	$315,498
														Subtotal = $315,498

Issue Date FY: 2014 ( Subtotal = $333,083 )
2014	2014	BOWLING GREEN STATE UNIVERSITY	***	BOWLING GREEN	OH	43403	WOOD	USA	Biomedical Research and Research Training	001	5	9/26/2014	COMPETING CONTINUATION	$333,083
2014	2013	BOWLING GREEN STATE UNIVERSITY	***	BOWLING GREEN	OH	43403	WOOD	USA	Biomedical Research and Research Training	000	4	9/23/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $333,083

Issue Date FY: 2013 ( Subtotal = $294,173 )
2013	2013	BOWLING GREEN STATE UNIVERSITY	106 University Hall	BOWLING GREEN	OH	43403	WOOD	USA	Biomedical Research and Research Training	000	4	7/26/2013	NON-COMPETING CONTINUATION	$294,173
														Subtotal = $294,173

Issue Date FY: 2012 ( Subtotal = $304,899 )
2012	2012	BOWLING GREEN STATE UNIVERSITY	106 University Hall	BOWLING GREEN	OH	43403	WOOD	USA	Biomedical Research and Research Training	000	3	7/23/2012	NON-COMPETING CONTINUATION	$304,899
														Subtotal = $304,899

Issue Date FY: 2011 ( Subtotal = $304,967 )
2011	2011	BOWLING GREEN STATE UNIVERSITY	106 University Hall	BOWLING GREEN	OH	43403	WOOD	USA	Biomedical Research and Research Training	000	2	8/4/2011	NON-COMPETING CONTINUATION	$304,967
														Subtotal = $304,967

Issue Date FY: 2010 ( Subtotal = $334,523 )
2010	2010	BOWLING GREEN STATE UNIVERSITY	106 University Hall	BOWLING GREEN	OH	43403	WOOD	USA	Biomedical Research and Research Training	000	1	8/9/2010	NEW	$334,523
														Subtotal = $334,523

Grand Total All Awards = $4,015,852

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Integrated Resource for Nucleic Acid Structures

Award Number: R01GM085328

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/10/2010

PERIOD OF PERFORMANCE END DATE: 08/31/2024

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer