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Finite Elements For Biomechanics And Biophysics

Award Number: R01GM083925
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/17/2008
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Finite Elements For Biomechanics And Biophysics - PROJECT SUMMARY / ABSTRACT Finite element analysis has become an indispensable tool for research and discovery in the biomedical sciences. Historically, the lack of an open software environment that was tailored to the needs of the field hampered research progress, dissemination of research and sharing of models and results. To address these issues, we developed the FEBio software suite, a FE framework designed specifically for analysis in biomechanics and biophysics, during our first funding period (FY 2008-2011). FEBio employs mixture theory to account for the multi-constituent nature of biological tissues and fluids, unifying the classical fields of irreversible thermodynamics, solid mechanics, fluid mechanics, mass transport, chemical reactions and electrokinetics. During the second funding period (FY 2012-2015), we implemented chemical reactions between constituents of a mixture and we broadened the target audience for FEBio by developing a plugin environment that made it easy to add features or interface other software with FEBio. During our third funding period (FY 2016-2019), we developed a novel FE framework for simulation of compressible and incompressible CFD, extended this framework to enable analysis of FSI (Fluid-Structure Interaction) problems, and we enhanced algorithmic, analysis and numerical capabilities in FEBio by implementing efficient iterative linear solvers and preconditioners, new nonlinear solution strategies, and adaptive meshing. During our fourth funding period (FY 2020-2023), we introduced significant advances in the modeling of damage mechanics and fatigue failure in biological tissues, as well as the modeling of solute transport in fluid mechanics, fluid-structure interactions, and reactive multiphasic media. We developed a powerful graphical user interface and merged the pre-processing, finite element analysis, and post-processing packages into a single user environment called FEBio Studio. We also integrated the use of image data with the simulation pipeline, from model setup to model validation. In the current application we propose to advance our modeling techniques by (1) developing a modeling framework for thermomechanics in solids, fluids, and mixtures; (2) incorporating experimental data to constrain finite element solutions; (3) modeling immersed solid, biphasic, or multiphasic bodies in fluid domains, accounting for FSI and resolving the fluid shear stress in boundary layers surrounding the body; and (4) facilitating software development by the user community. These new capabilities will expand the applicability of FEBio to new fields of biomedical research, increasing our user base and facilitating scientific advancement.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $475,402 )
2025	2025	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	002	18	7/14/2025	NON-COMPETING CONTINUATION	$475,402
2025	2024	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	001	17	1/27/2025	COMPETING CONTINUATION	$246,461
2025	2023	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	000	16	1/27/2025	NON-COMPETING CONTINUATION	-$246,461
														Subtotal = $475,402

Issue Date FY: 2024 ( Subtotal = $504,123 )
2024	2024	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	000	17	9/17/2024	COMPETING CONTINUATION	$504,123
														Subtotal = $504,123

Issue Date FY: 2023 ( Subtotal = $436,722 )
2023	2023	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	000	16	6/27/2023	NON-COMPETING CONTINUATION	$436,722
														Subtotal = $436,722

Issue Date FY: 2022 ( Subtotal = $436,168 )
2022	2022	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	000	15	6/29/2022	NON-COMPETING CONTINUATION	$436,168
														Subtotal = $436,168

Issue Date FY: 2021 ( Subtotal = $664,384 )
2021	2021	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	000	14	6/9/2021	NON-COMPETING CONTINUATION	$435,634
2021	2021	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	003	14	9/22/2021	SUPPLEMENT FOR EXPANSION	$228,750
2021	2020	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	002	13	6/12/2021	COMPETING CONTINUATION	$274,754
2021	2019	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	001	12	6/12/2021	NON-COMPETING CONTINUATION	-$274,754
														Subtotal = $664,384

Issue Date FY: 2020 ( Subtotal = $448,250 )
2020	2020	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	000	13	9/7/2020	COMPETING CONTINUATION	$448,250
														Subtotal = $448,250

Issue Date FY: 2019 ( Subtotal = $412,768 )
2019	2019	UNIVERSITY OF UTAH, THE	201 S PRESIDENT CIRCLE RM 408	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	000	12	8/26/2019	NON-COMPETING CONTINUATION	$412,768
														Subtotal = $412,768

Issue Date FY: 2018 ( Subtotal = $412,343 )
2018	2018	UNIVERSITY OF UTAH, THE	201 S PRESIDENT CIRCLE RM 408	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	000	11	8/30/2018	NON-COMPETING CONTINUATION	$412,343
														Subtotal = $412,343

Issue Date FY: 2017 ( Subtotal = $410,856 )
2017	2017	UNIVERSITY OF UTAH, THE	201 S PRESIDENT CIRCLE RM 408	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	002	10	8/17/2017	NON-COMPETING CONTINUATION	$410,856
2017	2016	UNIVERSITY OF UTAH, THE	201 S PRESIDENT CIRCLE RM 408	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	001	9	1/21/2017	COMPETING CONTINUATION	$43,923
2017	2015	UNIVERSITY OF UTAH, THE	201 S PRESIDENT CIRCLE RM 408	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	000	8	1/21/2017	NON-COMPETING CONTINUATION	-$43,923
														Subtotal = $410,856

Issue Date FY: 2016 ( Subtotal = $429,008 )
2016	2016	UNIVERSITY OF UTAH	201 SOUTH PRESIDENT`S CIRCLE	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	001	9	8/16/2016	COMPETING CONTINUATION	$0
2016	2016	UNIVERSITY OF UTAH	201 SOUTH PRESIDENT`S CIRCLE	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	000	9	8/8/2016	COMPETING CONTINUATION	$429,008
														Subtotal = $429,008

Issue Date FY: 2015 ( Subtotal = $302,835 )
2015	2015	UNIVERSITY OF UTAH	201 SOUTH PRESIDENT`S CIRCLE	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	000	8	8/11/2015	NON-COMPETING CONTINUATION	$302,835
														Subtotal = $302,835

Issue Date FY: 2014 ( Subtotal = $302,835 )
2014	2014	UNIVERSITY OF UTAH	201 SOUTH PRESIDENT`S CIRCLE	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	000	7	8/15/2014	NON-COMPETING CONTINUATION	$302,835
														Subtotal = $302,835

Issue Date FY: 2013 ( Subtotal = $292,236 )
2013	2013	UNIVERSITY OF UTAH	201 SOUTH PRESIDENT`S CIRCLE	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	000	6	8/28/2013	NON-COMPETING CONTINUATION	$292,236
														Subtotal = $292,236

Issue Date FY: 2012 ( Subtotal = $305,935 )
2012	2012	UNIVERSITY OF UTAH	201 SOUTH PRESIDENT`S CIRCLE	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	001	5	8/20/2012	COMPETING CONTINUATION	$305,935
2012	2011	UNIVERSITY OF UTAH	201 SOUTH PRESIDENT`S CIRCLE	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	000	4	8/17/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $305,935

Issue Date FY: 2011 ( Subtotal = $320,078 )
2011	2011	UNIVERSITY OF UTAH	201 SOUTH PRESIDENT`S CIRCLE	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	000	4	8/30/2011	NON-COMPETING CONTINUATION	$320,078
														Subtotal = $320,078

Issue Date FY: 2010 ( Subtotal = $323,311 )
2010	2010	UNIVERSITY OF UTAH	201 SOUTH PRESIDENT`S CIRCLE	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	000	3	8/31/2010	NON-COMPETING CONTINUATION	$323,311
														Subtotal = $323,311

Issue Date FY: 2009 ( Subtotal = $326,577 )
2009	2009	UNIVERSITY OF UTAH	201 SOUTH PRESIDENT`S CIRCLE	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	000	2	8/31/2009	NON-COMPETING CONTINUATION	$326,577
														Subtotal = $326,577

Issue Date FY: 2008 ( Subtotal = $339,202 )
2008	2008	UNIVERSITY OF UTAH	201 SOUTH PRESIDENT`S CIRCLE	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	000	1	9/26/2008	NEW	$339,202
														Subtotal = $339,202

Grand Total All Awards = $7,143,033

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Finite Elements For Biomechanics And Biophysics

Award Number: R01GM083925

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/17/2008

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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