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MECHANISM AND REGULATION OF DNA RECOMBINATION IN SACCHAROMYCES CEREVISIAE

Award Number: R01GM080600
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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MECHANISM AND REGULATION OF DNA RECOMBINATION IN SACCHAROMYCES CEREVISIAE - Most of a cell’s DNA is packaged into chromosomes located within the nucleus. An additional small circular genome encoding only a few genes is located in the mitochondria. In some circumstances, cells release extrachromosomal pieces of DNA from mitochondrial DNA (mtDNA), from the nuclear genome or in the form of retrotransposon cDNA (rt-cDNA). There are two consequences of DNA fragment release. First, many organisms activate an innate immune response that may result in chronic inflammation and cell death. This inflammation may lead to severe diseases in human including some cases of heart failure, Parkinson’s disease or aging- related chronic inflammation. Second, released DNA can be inserted at DNA double strand breaks (DSBs) causing genome instability. Insertions of mtDNA, rt-cDNA and chromosome fragments destabilize the genome and are common in cancer, whereas rare gene insertions at the V(D)J locus constitute a pathway of antibody diversification. Despite a large body of evidence showing severe consequences of the release of DNA fragments, it remains unknown what cellular events lead to its generation. The goal of this proposal is to understand the mechanisms of free DNA formation and its insertion at DSBs. We will: (i) develop a high throughput method to capture and sequence free DNA, (ii) understand the mechanism of insertion of free DNA at DSBs by nonhomologous end joining and by alternative end joining, and (iii) decipher the mechanisms of linear DNA fragment release from mitochondria and from the nuclear genome.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $355,000 )
2024	2024	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	001	17	6/20/2024	NON-COMPETING CONTINUATION	$35,499
2024	2024	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	17	2/8/2024	NON-COMPETING CONTINUATION	$319,501
														Subtotal = $355,000

Issue Date FY: 2023 ( Subtotal = $365,240 )
2023	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	001	16	5/15/2023	SUPPLEMENT FOR EXPANSION	$10,240
2023	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	16	2/22/2023	NON-COMPETING CONTINUATION	$355,000
														Subtotal = $365,240

Issue Date FY: 2022 ( Subtotal = $355,000 )
2022	2022	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	001	15	7/27/2022	NON-COMPETING CONTINUATION	$35,502
2022	2022	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	15	2/16/2022	NON-COMPETING CONTINUATION	$319,498
														Subtotal = $355,000

Issue Date FY: 2021 ( Subtotal = $370,000 )
2021	2021	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	002	14	9/5/2021	COMPETING CONTINUATION	$50,164
2021	2021	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	14	4/27/2021	COMPETING CONTINUATION	$370,000
2021	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	001	13	9/5/2021	NON-COMPETING CONTINUATION	-$50,164
														Subtotal = $370,000

Issue Date FY: 2020 ( Subtotal = $306,472 )
2020	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	13	4/13/2020	NON-COMPETING CONTINUATION	$306,472
														Subtotal = $306,472

Issue Date FY: 2019 ( Subtotal = $306,472 )
2019	2019	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	12	4/10/2019	NON-COMPETING CONTINUATION	$306,472
														Subtotal = $306,472

Issue Date FY: 2018 ( Subtotal = $306,472 )
2018	2018	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	11	4/26/2018	NON-COMPETING CONTINUATION	$306,472
														Subtotal = $306,472

Issue Date FY: 2017 ( Subtotal = $306,472 )
2017	2017	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	003	10	9/9/2017	COMPETING CONTINUATION	$0
2017	2017	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	001	10	3/13/2017	COMPETING CONTINUATION	$306,472
2017	2016	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	002	9	9/9/2017	EXTENSION WITH OR WITHOUT FUNDS	$0
2017	2015	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	8	1/14/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $306,472

Issue Date FY: 2016 ( Subtotal = $295,513 )
2016	2016	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	9	4/14/2016	EXTENSION WITH OR WITHOUT FUNDS	$295,513
														Subtotal = $295,513

Issue Date FY: 2015 ( Subtotal = $295,513 )
2015	2015	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	8	4/15/2015	NON-COMPETING CONTINUATION	$295,513
														Subtotal = $295,513

Issue Date FY: 2014 ( Subtotal = $295,513 )
2014	2014	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	7	4/2/2014	NON-COMPETING CONTINUATION	$295,513
														Subtotal = $295,513

Issue Date FY: 2013 ( Subtotal = $295,513 )
2013	2013	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	6	5/29/2013	COMPETING CONTINUATION	$295,513
														Subtotal = $295,513

Issue Date FY: 2011 ( Subtotal = $279,329 )
2011	2011	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	5	5/27/2011	NON-COMPETING CONTINUATION	$279,329
														Subtotal = $279,329

Issue Date FY: 2010 ( Subtotal = $282,150 )
2010	2010	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	4	4/29/2010	NON-COMPETING CONTINUATION	$282,150
														Subtotal = $282,150

Issue Date FY: 2009 ( Subtotal = $561,047 )
2009	2009	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	3	4/20/2009	NON-COMPETING CONTINUATION	$285,000
2009	2009	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Recovery Act Research Support	001	3	8/12/2009	SUPPLEMENT FOR EXPANSION	$276,047
														Subtotal = $561,047

Issue Date FY: 2008 ( Subtotal = $285,000 )
2008	2008	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	2	4/21/2008	NON-COMPETING CONTINUATION	$285,000
														Subtotal = $285,000

Issue Date FY: 2007 ( Subtotal = $280,770 )
2007	2007	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	1	4/23/2007	NEW	$280,770
														Subtotal = $280,770

Grand Total All Awards = $5,541,476

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MECHANISM AND REGULATION OF DNA RECOMBINATION IN SACCHAROMYCES CEREVISIAE

Award Number: R01GM080600

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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