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Chemical Probes to Study Copper Biology

Award Number: R01GM079465
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Chemical Probes to Study Copper Biology - Project Summary/Abstract Copper is an essential metal nutrient that plays important roles in human health and disease. The potent redox activity of copper is required for a diverse array of physiological processes including respiration, antioxidant defense, and hormone and neurotransmitter biosynthesis and metabolism. However, dysregulated copper homeostasis can contribute to cancer, metabolic diseases like obesity and diabetes, and heart and neurodegenerative disorders, often through aberrant oxidative stress and damage pathways. We are developing new chemical reagents that enable copper-specific imaging in biological models to help decipher the contributions of copper to healthy and disease states, spanning the subcellular to cellular to animal level, along with chemoproteomics approaches to identify and target copper-dependent disease vulnerabilities. The scientific premise is that building a copper imaging and proteomics toolkit will provide foundational chemical reagents to both further our understanding of the roles of copper in physiology and pathology and open new avenues for therapeutic intervention. This competitive renewal application is driven by design innovations where we invent new generalizable, activity-based sensing platforms for copper detection and activity-based proteomics for copper-dependent disease targets, as well as scientific rigor in the synthesis and use of multiple characterization techniques to apply these tools in cell and animal models. Specifically, we will pursue protein - labeled copper probes to study how copper is stored, trafficked, and utilized at the subcellular and cellular level, chemiluminescent indicators to enable dynamic and longitudinal copper imaging at the tissue and animal level, and chemoproteomics approaches to identify copper-dependent druggable sites and covalent fragment lead compounds against these targets.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $441,524 )
2025	2025	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	005	21	3/24/2025	NON-COMPETING CONTINUATION	$431,961
2025	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	003	19	3/20/2025	NON-COMPETING CONTINUATION	-$1
2025	2024	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	001	20	1/1/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$448,138
2025	2024	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	004	20	3/20/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$156,014
2025	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	19	1/1/2025	NON-COMPETING CONTINUATION	-$438,575
2025	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	002	18	3/20/2025	COMPETING CONTINUATION	-$156,013
														Subtotal = $441,524

Issue Date FY: 2024 ( Subtotal = $438,576 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	004	19	6/13/2024	NON-COMPETING CONTINUATION	$43,857
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	003	19	3/18/2024	NON-COMPETING CONTINUATION	$394,719
2024	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	18	3/7/2024	COMPETING CONTINUATION	$44,927
2024	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	002	17	3/7/2024	SUPPLEMENT FOR EXPANSION	-$15,168
2024	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	17	3/7/2024	NON-COMPETING CONTINUATION	-$29,759
														Subtotal = $438,576

Issue Date FY: 2023 ( Subtotal = $441,375 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	18	3/28/2023	COMPETING CONTINUATION	$441,375
														Subtotal = $441,375

Issue Date FY: 2022 ( Subtotal = $586,574 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	17	5/16/2022	NON-COMPETING CONTINUATION	$38,856
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	002	17	5/24/2022	SUPPLEMENT FOR EXPANSION	$198,036
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	17	3/9/2022	NON-COMPETING CONTINUATION	$349,682
														Subtotal = $586,574

Issue Date FY: 2021 ( Subtotal = $398,613 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	16	3/17/2021	NON-COMPETING CONTINUATION	$398,613
														Subtotal = $398,613

Issue Date FY: 2020 ( Subtotal = $408,351 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	002	15	3/16/2020	NON-COMPETING CONTINUATION	$408,351
2020	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	14	2/23/2020	COMPETING CONTINUATION	$44,917
2020	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	13	2/23/2020	NON-COMPETING CONTINUATION	-$44,917
														Subtotal = $408,351

Issue Date FY: 2019 ( Subtotal = $338,734 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	000	14	2/28/2019	COMPETING CONTINUATION	$338,734
														Subtotal = $338,734

Issue Date FY: 2018 ( Subtotal = $344,486 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	000	13	3/27/2018	NON-COMPETING CONTINUATION	$310,037
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	001	13	5/18/2018	NON-COMPETING CONTINUATION	$34,449
														Subtotal = $344,486

Issue Date FY: 2017 ( Subtotal = $344,383 )
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	001	12	6/8/2017	NON-COMPETING CONTINUATION	$34,439
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	000	12	3/21/2017	NON-COMPETING CONTINUATION	$309,944
														Subtotal = $344,383

Issue Date FY: 2016 ( Subtotal = $344,641 )
2016	2016	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	000	11	3/31/2016	NON-COMPETING CONTINUATION	$344,641
														Subtotal = $344,641

Issue Date FY: 2015 ( Subtotal = $344,891 )
2015	2015	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	000	10	8/3/2015	COMPETING CONTINUATION	$344,891
														Subtotal = $344,891

Issue Date FY: 2014 ( Subtotal = $362,260 )
2014	2014	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	000	9	6/30/2014	NON-COMPETING CONTINUATION	$362,260
														Subtotal = $362,260

Issue Date FY: 2013 ( Subtotal = $342,534 )
2013	2013	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	001	8	9/25/2013	SUPPLEMENT FOR EXPANSION	$45,217
2013	2013	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	000	8	6/3/2013	NON-COMPETING CONTINUATION	$297,317
														Subtotal = $342,534

Issue Date FY: 2012 ( Subtotal = $312,180 )
2012	2012	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	000	7	5/18/2012	NON-COMPETING CONTINUATION	$312,180
														Subtotal = $312,180

Issue Date FY: 2011 ( Subtotal = $317,995 )
2011	2011	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	001	6	9/16/2011	COMPETING CONTINUATION	$317,995
2011	2010	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	000	5	9/16/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $317,995

Issue Date FY: 2010 ( Subtotal = $243,403 )
2010	2010	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	000	5	8/23/2010	NON-COMPETING CONTINUATION	$243,403
														Subtotal = $243,403

Issue Date FY: 2009 ( Subtotal = $245,861 ) (Continued on the next page)
Grand Total All Awards = $7,111,090

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Chemical Probes to Study Copper Biology

Award Number: R01GM079465

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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