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Mechanism of RNA Localization in Drosophila Development

Award Number: R01GM067758
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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¿ DESCRIPTION (provided by applicant): Messenger RNA localization plays a key role in creating the asymmetric distributions of proteins necessary for cellular and developmental polarity. Impairment of mRNA localization pathways has been implicated in human diseases such as spinal muscular atrophy and fragile X syndrome and targeting of mRNAs to cancer cell protrusions suggests a role in metastasis. The sorting of specific mRNAs to different subcellular domains is a complex process involving the assembly and trafficking of ribonucleoprotein particles (RNPs). How specificity is conferred on this process, particularly in cells where many mRNAs are localized concurrently, is poorly understood. This proposal integrates biochemical, genetic, and quantitative and live imaging-based approaches to investigate how different mRNAs are specifically recognized to form localization competent RNPs and assembled into higher order, functional RNA granules. Aims 1 and 2 address the end masse localization of numerous transcripts to the germ plasm at the posterior of the Drosophila oocyte and their differential inheritance by germ cell progenitors. This system affords an ideal opportunity to investigate the molecular mechanisms that regulate the formation, composition, and behavior of RNPs essential for localization and function in generating asymmetry. Aim 3 capitalizes on our recent identification of a large number of localized RNAs in Drosophila sensory neuron dendrites. The major goals of this aim are to critically assess the functional significance of RNA localization in neurons and to probe the generality of the mechanistic principles emerging from Aims 1 and 2.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = -$99 )
2018	2017	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	000	14	5/31/2018	SUPPLEMENT FOR EXPANSION	-$99
														Subtotal = -$99

Issue Date FY: 2017 ( Subtotal = $379,425 )
2017	2017	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	005	14	5/3/2017	SUPPLEMENT FOR EXPANSION	$8,000
2017	2017	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	008	14	6/20/2017	NON-COMPETING CONTINUATION	$37,143
2017	2017	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	004	14	3/8/2017	NON-COMPETING CONTINUATION	$334,282
2017	2016	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	007	13	6/6/2017	COMPETING CONTINUATION	$16
2017	2016	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	003	13	12/21/2016	COMPETING CONTINUATION	$84
2017	2015	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	001	12	12/17/2016	NON-COMPETING CONTINUATION	-$84
2017	2015	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	006	12	6/6/2017	NON-COMPETING CONTINUATION	-$16
2017	2009	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Trans-NIH Recovery Act Research Support	000	6	12/17/2016	SUPPLEMENT FOR EXPANSION	$84
2017	2009	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Trans-NIH Recovery Act Research Support	002	6	12/21/2016	SUPPLEMENT FOR EXPANSION	-$84
														Subtotal = $379,425

Issue Date FY: 2016 ( Subtotal = $373,138 )
2016	2016	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	000	13	3/31/2016	COMPETING CONTINUATION	$373,138
														Subtotal = $373,138

Issue Date FY: 2015 ( Subtotal = $429,806 )
2015	2015	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	000	11	3/6/2015	SUPPLEMENT FOR EXPANSION	$5,383
2015	2015	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	001	12	3/19/2015	NON-COMPETING CONTINUATION	$424,423
														Subtotal = $429,806

Issue Date FY: 2014 ( Subtotal = $357,586 )
2014	2014	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	000	11	3/4/2014	NON-COMPETING CONTINUATION	$357,586
														Subtotal = $357,586

Issue Date FY: 2013 ( Subtotal = $364,162 )
2013	2013	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	001	10	6/27/2013	NON-COMPETING CONTINUATION	$23,243
2013	2013	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	002	10	8/26/2013	SUPPLEMENT FOR EXPANSION	$19,092
2013	2013	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	000	10	3/11/2013	NON-COMPETING CONTINUATION	$321,827
														Subtotal = $364,162

Issue Date FY: 2012 ( Subtotal = $357,586 )
2012	2012	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	000	9	3/26/2012	COMPETING CONTINUATION	$357,586
														Subtotal = $357,586

Issue Date FY: 2011 ( Subtotal = $325,676 )
2011	2011	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	001	8	6/22/2011	NON-COMPETING CONTINUATION	$29,607
2011	2011	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	000	8	3/24/2011	NON-COMPETING CONTINUATION	$296,069
2011	2009	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Trans-NIH Recovery Act Research Support	002	6	9/22/2011	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $325,676

Issue Date FY: 2010 ( Subtotal = $328,966 )
2010	2010	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	000	7	3/22/2010	NON-COMPETING CONTINUATION	$328,966
														Subtotal = $328,966

Issue Date FY: 2009 ( Subtotal = $790,045 )
2009	2009	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	001	6	4/29/2009	NON-COMPETING CONTINUATION	$33,229
2009	2009	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Trans-NIH Recovery Act Research Support	002	6	9/25/2009	SUPPLEMENT FOR EXPANSION	$457,756
2009	2009	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	000	6	3/13/2009	NON-COMPETING CONTINUATION	$299,060
														Subtotal = $790,045

Issue Date FY: 2008 ( Subtotal = $349,636 )
2008	2008	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	001	5	8/15/2008	SUPPLEMENT FOR EXPANSION	$25,000
2008	2008	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	000	5	3/28/2008	COMPETING CONTINUATION	$324,636
														Subtotal = $349,636

Issue Date FY: 2007 ( Subtotal = $291,322 )
2007	2007	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	000	4	1/24/2007	NON-COMPETING CONTINUATION	$291,322
														Subtotal = $291,322

Issue Date FY: 2006 ( Subtotal = $302,562 )
2006	2006	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	001	3	9/22/2006	SUPPLEMENT FOR EXPANSION	$2,539
2006	2006	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	000	3	1/16/2006	NON-COMPETING CONTINUATION	$300,023
														Subtotal = $302,562

Issue Date FY: 2005 ( Subtotal = $307,243 )
2005	2005	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	000	2	1/21/2005	NON-COMPETING CONTINUATION	$307,243
														Subtotal = $307,243

Issue Date FY: 2004 ( Subtotal = $303,151 )
2004	2004	PRINCETON UNIVERSITY	POST OFFICE BOX 5292	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	000	1	1/26/2004	NEW	$303,151
														Subtotal = $303,151

Grand Total All Awards = $5,260,205

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Mechanism of RNA Localization in Drosophila Development

Award Number: R01GM067758

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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