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TETRAHYMENA GENOME SEQUENCING PROJECT

Award Number: R01GM067012
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2003
PERIOD OF PERFORMANCE END DATE: 03/31/2006

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TETRAHYMENA GENOME SEQUENCING PROJECT - DESCRIPTION (provided by applicant): Tetrahymena thermophila is an excellent microbial organism for fundamental eukaryotic experimental cell and molecular biology and for comparative and functional genomics. Tetrahymena belongs to an independent eukaryotic clade, the AIveolata, yet its genome has conserved a remarkably degree of functional similarity to the human genome. Robust and novel molecular genetic tools have placed Tetrahymena at the forefront of experimental, in vivo functional genomics research. Tetrahymena is thus also an excellent unicellular genetic animal model organism for the investigation of human biology that has been evolutionarily lost by yeast. The primary goal of this project, a collaborative effort of TIGR, the Tetrahymena research community and the Saccharomyces Genome Database, is the whole-genome shotgun-sequencing, assembly and annotation of the expressed (macronuclear) T. thermophila genome. The project has three aims: 1) To whole-genome shotgun sequence and assemble the macronuclear genome to a depth of 8-fold sequence coverage. This coverage should be sufficient to discover nearly all the genes, and provide sequence of high enough quality to be able to directly exploit the advanced tools for post genomic analysis available in Tetrahymena. 2) To annotate and analyze the genome sequence, including the identification of putative genes, prediction of gene function, and other features standard for genomic analysis. 3) To facilitate unrestricted, user-friendly access to the T. thermophila genome sequence by releasing the sequence data immediately to external sequence databases and by the creation of three interlinked database resources: a TIGR website, a manually curated Tetrahymena Genome Database and a Tetrahymena-specific section in the NCBI "Genomic Biology" website.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2005 ( Subtotal = $1,373,429 )
2005	2005	INSTITUTE FOR GENOMIC RESEARCH (THE)	9712 MEDICAL CENTER DRIVE	ROCKVILLE	MD	20850	MONTGOMERY	USA	Biomedical Research and Research Training	000	3	3/24/2005	NON-COMPETING CONTINUATION	$1,373,429
														Subtotal = $1,373,429

Issue Date FY: 2004 ( Subtotal = $1,391,005 )
2004	2004	INSTITUTE FOR GENOMIC RESEARCH (THE)	9712 MEDICAL CENTER DRIVE	ROCKVILLE	MD	20850	MONTGOMERY	USA	Biomedical Research and Research Training	000	2	4/16/2004	NON-COMPETING CONTINUATION	$1,391,005
														Subtotal = $1,391,005

Issue Date FY: 2003 ( Subtotal = $1,229,549 )
2003	2003	INSTITUTE FOR GENOMIC RESEARCH (THE)	9712 MEDICAL CENTER DRIVE	ROCKVILLE	MD	20850	MONTGOMERY	USA	Genetics and Developmental Biology Research and Research Training	001	1	9/1/2003	SUPPLEMENT FOR EXPANSION	$42,463
2003	2003	INSTITUTE FOR GENOMIC RESEARCH (THE)	9712 MEDICAL CENTER DRIVE	ROCKVILLE	MD	20850	MONTGOMERY	USA	Genetics and Developmental Biology Research and Research Training	000	1		NEW	$1,187,086
														Subtotal = $1,229,549

Grand Total All Awards = $3,993,983

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TETRAHYMENA GENOME SEQUENCING PROJECT

Award Number: R01GM067012

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2003

PERIOD OF PERFORMANCE END DATE: 03/31/2006

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