Friday, November 22, 2024 11/22/2024

Genetic Biochemical Studies of Signaling in Growth and Acclimation

Award Number: R01GM066258
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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View Award Abstract

The long-term goal of this project is to understand the molecular networks through which hormones, environmental signals, and nutrients together control plant growth and development. As sessile organisms, plants have evolved complex and robust cellular signaling systems to regulate growth and metabolism according to internal status and environmental conditions. Dissecting these plant regulatory systems not only is important for crop resilience and food security but also can improve human health, as many signaling mechanisms are highly conserved in plants, humans, and human parasites. This research project aims to dissect the cellular signaling and regulatory networks that integrate hormonal, metabolic, and environmental signals. To gain a comprehensive understanding of the complex system, we integrate a broad range of research approaches including genetics, genomics, proteomics, structural biology, cell biology, and chemical proteomic approaches. We also use both muti-cellular and single-cellular model systems (Arabidopsis and Chlamydomonas) to gain insight into the conserved mechanisms such as cell cycle regulation and the evolution of inter-cellular signaling mechanisms underlying cell-cell communication, development, and morphogenesis. In the past two decades, we have elucidated molecular mechanisms by which the brassinosteroid (BR) hormone acts through the cell surface receptor kinase BRI1 and its downstream phosphorylation cascade to regulate gene expression and plant growth, cross-talks with other signaling pathways to regulate development and environmental responses, and intersects with sugar-signaling pathways to optimize growth and acclimation. We have also discovered signaling mechanisms that regulate cell division, elongation, differentiation, and innate immunity. Furthermore, we have recently generated proteomic maps of the nutrient/sugar-sensing O-glycosylation (O-GlcNAc and O-fucose) pathways and discovered their convergence with the BR-regulated phosphorylation pathway. Our research elucidates a signal- processing network that controls plant growth according to nutrient/sugar availability, hormonal instructions, and environmental cues, and increases our molecular insight into signaling mechanisms involving protein-protein interactions and protein modifications by phosphorylation and glycosylation. We focus on proteins that are conserved in humans or human parasites, and thus our research also informs medical research. Our research will benefit human well-being by improving food security, environmental sustainability, and drug development/discovery.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $604,743 )
2024	2024	CARNEGIE INSTITUTION OF WASHINGTON	5241 BROAD BRANCH RD NW	WASHINGTON	DC	20015	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	003	22	6/27/2024	COMPETING CONTINUATION	$604,743
2024	2023	CARNEGIE INSTITUTION OF WASHINGTON	5241 BROAD BRANCH RD NW	WASHINGTON	DC	20015	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	002	21	6/26/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	CARNEGIE INSTITUTION OF WASHINGTON	5241 BROAD BRANCH RD NW	WASHINGTON	DC	20015	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	001	21	6/26/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	CARNEGIE INSTITUTION OF WASHINGTON	5241 BROAD BRANCH RD NW	WASHINGTON	DC	20015	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	000	21	6/26/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $604,743

Issue Date FY: 2023 ( Subtotal = $719,073 )
2023	2023	CARNEGIE INSTITUTION OF WASHINGTON	5241 BROAD BRANCH RD NW	WASHINGTON	DC	20015	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	001	21	7/24/2023	SUPPLEMENT FOR EXPANSION	$141,679
2023	2023	CARNEGIE INSTITUTION OF WASHINGTON	5241 BROAD BRANCH RD NW	WASHINGTON	DC	20015	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	002	21	7/25/2023	SUPPLEMENT FOR EXPANSION	$16,017
2023	2023	CARNEGIE INSTITUTION OF WASHINGTON	5241 BROAD BRANCH RD NW	WASHINGTON	DC	20015	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	000	21	7/4/2023	NON-COMPETING CONTINUATION	$561,377
														Subtotal = $719,073

Issue Date FY: 2022 ( Subtotal = $625,285 )
2022	2022	CARNEGIE INSTITUTION OF WASHINGTON	5251 BROAD BRANCH RD NW	WASHINGTON	DC	20015	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	001	19	8/25/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2022	CARNEGIE INSTITUTION OF WASHINGTON	5251 BROAD BRANCH RD NW	WASHINGTON	DC	20015	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	000	19	3/28/2022	SUPPLEMENT FOR EXPANSION	$63,908
2022	2022	CARNEGIE INSTITUTION OF WASHINGTON	5251 BROAD BRANCH RD NW	WASHINGTON	DC	20015	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	002	20	8/26/2022	NON-COMPETING CONTINUATION	$561,377
														Subtotal = $625,285

Issue Date FY: 2021 ( Subtotal = $561,377 )
2021	2021	CARNEGIE INSTITUTION OF WASHINGTON	1530 P ST NW	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	002	19	8/31/2021	NON-COMPETING CONTINUATION	$561,377
2021	2020	CARNEGIE INSTITUTION OF WASHINGTON	5251 BROAD BRANCH RD NW	WASHINGTON	DC	20015	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	001	18	7/10/2021	COMPETING CONTINUATION	$101,556
2021	2019	CARNEGIE INSTITUTION OF WASHINGTON	5251 BROAD BRANCH RD NW	WASHINGTON	DC	20015	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	000	17	7/10/2021	NON-COMPETING CONTINUATION	-$101,556
														Subtotal = $561,377

Issue Date FY: 2020 ( Subtotal = $561,377 )
2020	2020	CARNEGIE INSTITUTION OF WASHINGTON	1530 P ST NW	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	001	18	9/4/2020	COMPETING CONTINUATION	$561,377
2020	2019	CARNEGIE INSTITUTION OF WASHINGTON	1530 P ST NW	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	000	17	8/27/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $561,377

Issue Date FY: 2019 ( Subtotal = $506,370 )
2019	2019	CARNEGIE INSTITUTION OF WASHINGTON	1530 P ST NW	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	000	17	5/3/2019	NON-COMPETING CONTINUATION	$506,370
														Subtotal = $506,370

Issue Date FY: 2018 ( Subtotal = $506,370 )
2018	2018	CARNEGIE INSTITUTION OF WASHINGTON	1530 P ST NW	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	000	16	5/22/2018	NON-COMPETING CONTINUATION	$506,370
														Subtotal = $506,370

Issue Date FY: 2017 ( Subtotal = $481,201 )
2017	2017	CARNEGIE INSTITUTION OF WASHINGTON	1530 P ST NW	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	003	15	6/20/2017	NON-COMPETING CONTINUATION	$48,120
2017	2017	CARNEGIE INSTITUTION OF WASHINGTON	1530 P ST NW	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	000	15	4/17/2017	NON-COMPETING CONTINUATION	$433,081
2017	2016	CARNEGIE INSTITUTION OF WASHINGTON	1530 P ST NW	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	002	14	4/21/2017	COMPETING CONTINUATION	$34,017
2017	2015	CARNEGIE INSTITUTION OF WASHINGTON	1530 P ST NW	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	001	13	4/21/2017	NON-COMPETING CONTINUATION	-$34,017
														Subtotal = $481,201

Issue Date FY: 2016 ( Subtotal = $496,331 )
2016	2016	CARNEGIE INSTITUTION OF WASHINGTON	1530 P. STREET N. W.	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	000	14	5/12/2016	COMPETING CONTINUATION	$496,331
														Subtotal = $496,331

Issue Date FY: 2015 ( Subtotal = $415,578 )
2015	2015	CARNEGIE INSTITUTION OF WASHINGTON	1530 P. STREET N. W.	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	000	13	6/8/2015	NON-COMPETING CONTINUATION	$415,578
														Subtotal = $415,578

Issue Date FY: 2014 ( Subtotal = $400,820 )
2014	2014	CARNEGIE INSTITUTION OF WASHINGTON	1530 P. STREET N. W.	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	001	12	7/25/2014	SUPPLEMENT FOR EXPANSION	$74,486
2014	2014	CARNEGIE INSTITUTION OF WASHINGTON	1530 P. STREET N. W.	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	000	12	5/19/2014	NON-COMPETING CONTINUATION	$326,334
														Subtotal = $400,820

Issue Date FY: 2013 ( Subtotal = $331,406 )
2013	2013	CARNEGIE INSTITUTION OF WASHINGTON	1530 P. STREET N. W.	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	000	11	4/29/2013	NON-COMPETING CONTINUATION	$309,086
2013	2013	CARNEGIE INSTITUTION OF WASHINGTON	1530 P. STREET N. W.	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	001	11	6/27/2013	NON-COMPETING CONTINUATION	$22,320
														Subtotal = $331,406

Issue Date FY: 2012 ( Subtotal = $349,772 )
2012	2012	CARNEGIE INSTITUTION OF WASHINGTON	1530 P. STREET N. W.	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	002	10	8/27/2012	COMPETING CONTINUATION	-$3,680
2012	2012	CARNEGIE INSTITUTION OF WASHINGTON	1530 P. STREET N. W.	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	001	10	4/9/2012	COMPETING CONTINUATION	$353,452
2012	2010	CARNEGIE INSTITUTION OF WASHINGTON	1530 P. STREET N. W.	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	000	9	4/9/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $349,772

Issue Date FY: 2010 ( Subtotal = $465,216 )
2010	2010	CARNEGIE INSTITUTION OF WASHINGTON	1530 P. STREET N. W.	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Trans-NIH Recovery Act Research Support	000	8	1/8/2010	SUPPLEMENT FOR EXPANSION	$161,402
2010	2010	CARNEGIE INSTITUTION OF WASHINGTON	1530 P. STREET N. W.	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	001	9	8/9/2010	NON-COMPETING CONTINUATION	$303,814
														Subtotal = $465,216

Issue Date FY: 2009 ( Subtotal = $306,883 )
2009	2009	CARNEGIE INSTITUTION OF WASHINGTON	1530 P. STREET N. W.	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	000	8	7/22/2009	NON-COMPETING CONTINUATION	$306,883
														Subtotal = $306,883

Issue Date FY: 2008 ( Subtotal = $306,883 )
2008	2008	CARNEGIE INSTITUTION OF WASHINGTON	1530 P. STREET N. W.	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	000	7	7/28/2008	NON-COMPETING CONTINUATION	$306,883
														Subtotal = $306,883

Grand Total All Awards = $9,266,530

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Genetic Biochemical Studies of Signaling in Growth and Acclimation

Award Number: R01GM066258

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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