Monday, October 7, 2024 10/7/2024

Regulation of Chromosome Segregation

Award Number: R01GM064386
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract Accurate cell division is critical for the proliferation and development of organisms. The precise partitioning of duplicated chromosomes to daughter cells is an essential event in the cell cycle. Defects in chromosome segregation lead to aneuploidy, the state where entire chromosomes are gained or loss. Aneuploidy is a the most common chromosomal abnormality in cancer cells and has been postulated to be a major factor in the evolution of cancer. It is also the leading cause of spontaneous miscarriages and hereditary birth defects in humans. The proposed work will lead to an understanding of the mechanisms that ensure accurate chromosome segregation and thus maintain genomic stability and prevent human disease. Chromosome segregation requires forces generated by spindle microtubules that are translated into chromosome movement through interactions with kinetochores, the highly conserved structures that assemble onto centromeric chromatin. Accurate segregation requires kinetochores to maintain load-bearing attachments to the ends of microtubules that are continually growing and shrinking. Kinetochores must also biorient and attach to microtubules from opposite poles. When there is a defect in biorientation, error correction systems destabilize improper attachments. In the next funding period, this proposal will use in vitro assays to address a number of outstanding questions about kinetochore assembly and function. 1) How is kinetochore assembly regulated? 2) How do outer kinetochore proteins contribute to force-dependent kinetochore-microtubule attachments? 3) How is the Aurora B error correction pathway regulated by tension? The proposal will use budding yeast for these studies because they are amenable to biochemical, genetic and cytological studies, and the yeast kinetochore is the best characterized to date. Taken together, these studies of kinetochores in budding yeast will lead toward an understanding of the fundamental mechanisms of segregation in all eukaryotes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$5,230 )
2024	2022	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	000	22	4/16/2024	NON-COMPETING CONTINUATION	-$5,230
														Subtotal = -$5,230

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	001	21	11/7/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$28
2023	2021	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	000	20	11/7/2022	NON-COMPETING CONTINUATION	-$28
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $352,000 )
2022	2022	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	002	22	7/20/2022	NON-COMPETING CONTINUATION	$352,000
2022	2021	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	000	20	6/10/2022	NON-COMPETING CONTINUATION	-$209,766
2022	2021	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	001	21	6/14/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$209,766
														Subtotal = $352,000

Issue Date FY: 2021 ( Subtotal = $352,000 )
2021	2021	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	000	20	7/30/2021	NON-COMPETING CONTINUATION	$352,000
														Subtotal = $352,000

Issue Date FY: 2020 ( Subtotal = $352,000 )
2020	2020	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	002	19	8/18/2020	NON-COMPETING CONTINUATION	$352,000
2020	2019	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	001	18	5/5/2020	COMPETING CONTINUATION	$30,644
2020	2018	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	000	17	5/5/2020	NON-COMPETING CONTINUATION	-$30,644
														Subtotal = $352,000

Issue Date FY: 2019 ( Subtotal = $352,000 )
2019	2019	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	001	18	8/9/2019	COMPETING CONTINUATION	$352,000
2019	2019	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	002	18	8/27/2019	COMPETING CONTINUATION	$0
2019	2018	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	000	17	8/6/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $352,000

Issue Date FY: 2018 ( Subtotal = $331,905 )
2018	2018	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	000	17	6/25/2018	NON-COMPETING CONTINUATION	$331,905
														Subtotal = $331,905

Issue Date FY: 2017 ( Subtotal = $331,905 )
2017	2017	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	000	16	7/4/2017	NON-COMPETING CONTINUATION	$331,905
														Subtotal = $331,905

Issue Date FY: 2016 ( Subtotal = $253,303 )
2016	2016	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	001	15	6/14/2016	NON-COMPETING CONTINUATION	$331,905
2016	2015	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	000	14	3/8/2016	COMPETING CONTINUATION	-$78,602
														Subtotal = $253,303

Issue Date FY: 2015 ( Subtotal = $564,921 )
2015	2015	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	001	14	7/24/2015	COMPETING CONTINUATION	$564,921
2015	2014	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	000	13	7/21/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $564,921

Issue Date FY: 2014 ( Subtotal = $366,406 )
2014	2014	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	000	13	6/30/2014	NON-COMPETING CONTINUATION	$366,406
														Subtotal = $366,406

Issue Date FY: 2013 ( Subtotal = $353,587 )
2013	2013	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	000	12	6/25/2013	NON-COMPETING CONTINUATION	$353,587
														Subtotal = $353,587

Issue Date FY: 2012 ( Subtotal = $366,411 )
2012	2012	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	000	11	7/11/2012	NON-COMPETING CONTINUATION	$366,411
														Subtotal = $366,411

Issue Date FY: 2011 ( Subtotal = $366,647 )
2011	2011	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	001	10	6/27/2011	COMPETING CONTINUATION	$366,647
2011	2010	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	000	9	6/27/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $366,647

Issue Date FY: 2010 ( Subtotal = $316,122 )
2010	2010	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	000	9	6/30/2010	NON-COMPETING CONTINUATION	$316,122
														Subtotal = $316,122

Issue Date FY: 2009 ( Subtotal = $474,024 )
2009	2009	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	000	8	8/4/2009	NON-COMPETING CONTINUATION	$312,690
2009	2009	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Trans-NIH Recovery Act Research Support	001	8	9/15/2009	SUPPLEMENT FOR EXPANSION	$161,334
														Subtotal = $474,024

Issue Date FY: 2008 ( Subtotal = $313,220 )
2008	2008	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	000	7	6/9/2008	NON-COMPETING CONTINUATION	$313,220
														Subtotal = $313,220

Issue Date FY: 2007 ( Subtotal = $311,942 )
2007	2007	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	000	6	6/18/2007	COMPETING CONTINUATION	$311,942
														Subtotal = $311,942

Issue Date FY: 2006 ( Subtotal = $300,450 )
2006	2006	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Biomedical Research and Research Training	000	5	2/2/2006	NON-COMPETING CONTINUATION	$300,450
														Subtotal = $300,450

Issue Date FY: 2005 ( Subtotal = $307,824 ) (Continued on the next page)
Grand Total All Awards = $7,227,649

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Regulation of Chromosome Segregation

Award Number: R01GM064386

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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