Wednesday, February 5, 2025 2/5/2025

Administrative supplement to purchase a plate reader

Award Number: R01GM061146
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY The RNA m7G cap has been recognized as a capstone in RNA metabolism in eukaryotes, thanks to decades of research that uncovered the mechanisms underlying its deposition, removal, and impacts on gene expression. However, recent discoveries showing that the m7G cap is not the only RNA cap indicate that our knowledge of RNA metabolism is far from complete. Nicotinamide adenine diphosphate (NAD+) has recently emerged as an RNA cap in bacteria, yeast, and humans, and our preliminary studies show that this cap is widespread in the model plant Arabidopsis; thus, NAD+ maybe a universal RNA cap in life. Existing evidence points to a dynamic nature of this RNA modification, as enzymes that deposit and remove the NAD+ cap have been identified in bacteria, humans, and Arabidopsis. The potentially dynamic nature of this RNA modification points to its as yet unknown regulatory functions in gene expression and biological processes. As NAD+ serves critical functions in cellular redox and energy homeostasis, it is possible that NAD+ capping/decapping in RNA is both regulated by and impacts cellular redox and metabolic homeostasis. Despite its potential importance, our knowledge of the NAD+ cap is at most rudimentary. The project seeks to understand the biology of the RNA NAD+ cap using the Arabidopsis model. Based on preliminary studies that documented the existence of NAD+-capped RNAs, implicated their translational status and revealed potential decapping enzymes, the project interrogates how the NAD+ cap is deposited and removed, how the NAD+ cap impacts gene expression, and what biological processes are regulated by RNA NAD+-capping/decapping. The sophisticated molecular and genetic resources in the Arabidopsis model not only allow for the understanding of this universal RNA modification in one domain of life, but also offer advantages of studying this RNA modification in an intact, multicellular life with relative ease. Findings on the RNA NAD+ cap from this project may have far-reaching impacts in agriculture and medicine.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$200,890 )
2025	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFC BUILDING	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	000	22	11/26/2024	NON-COMPETING CONTINUATION	-$168,634
2025	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFC BUILDING	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	001	22	11/26/2024	SUPPLEMENT FOR EXPANSION	-$32,256
														Subtotal = -$200,890

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFC BUILDING	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	000	22	5/27/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFC BUILDING	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	001	22	6/1/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $370,487 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	900 UNIVERSITY AVE	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	001	22	7/18/2022	SUPPLEMENT FOR EXPANSION	$59,487
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	900 UNIVERSITY AVE	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	000	22	5/19/2022	NON-COMPETING CONTINUATION	$311,000
														Subtotal = $370,487

Issue Date FY: 2021 ( Subtotal = $510,758 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFFICE BLDG	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	001	21	8/10/2021	SUPPLEMENT FOR EXPANSION	$199,758
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFFICE BLDG	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	000	21	5/3/2021	NON-COMPETING CONTINUATION	$311,000
														Subtotal = $510,758

Issue Date FY: 2020 ( Subtotal = $311,000 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFFICE BLDG	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	000	20	4/29/2020	NON-COMPETING CONTINUATION	$311,000
2020	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFFICE BLDG	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	002	19	5/2/2020	COMPETING CONTINUATION	$1,132
2020	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFFICE BLDG	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	001	18	5/2/2020	SUPPLEMENT FOR EXPANSION	-$1,132
														Subtotal = $311,000

Issue Date FY: 2019 ( Subtotal = $311,000 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFFICE BLDG	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	001	19	7/30/2019	COMPETING CONTINUATION	$311,000
2019	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFFICE BLDG	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	000	18	7/25/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $311,000

Issue Date FY: 2018 ( Subtotal = $361,763 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFFICE BLDG	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	002	18	9/8/2018	SUPPLEMENT FOR EXPANSION	$72,963
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFFICE BLDG	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	001	18	6/19/2018	NON-COMPETING CONTINUATION	$28,880
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFFICE BLDG	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	000	18	12/7/2017	NON-COMPETING CONTINUATION	$259,920
														Subtotal = $361,763

Issue Date FY: 2017 ( Subtotal = $285,081 )
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFFICE BLDG	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	001	17	8/3/2017	NON-COMPETING CONTINUATION	$28,509
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFFICE BLDG	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	000	17	12/23/2016	NON-COMPETING CONTINUATION	$256,572
														Subtotal = $285,081

Issue Date FY: 2016 ( Subtotal = $375,129 )
2016	2016	REGENTS, UNIVERSITY OF CALIFORNIA	POST OFFICE BOX 112	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	001	16	3/1/2016	NON-COMPETING CONTINUATION	$28,513
2016	2016	REGENTS, UNIVERSITY OF CALIFORNIA	POST OFFICE BOX 112	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	002	16	9/6/2016	SUPPLEMENT FOR EXPANSION	$90,000
2016	2016	REGENTS, UNIVERSITY OF CALIFORNIA	POST OFFICE BOX 112	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	000	16	12/24/2015	NON-COMPETING CONTINUATION	$256,616
														Subtotal = $375,129

Issue Date FY: 2015 ( Subtotal = $285,174 )
2015	2015	REGENTS, UNIVERSITY OF CALIFORNIA	POST OFFICE BOX 112	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	001	15	12/29/2014	COMPETING CONTINUATION	$285,174
2015	2013	REGENTS, UNIVERSITY OF CALIFORNIA	POST OFFICE BOX 112	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	000	14	12/24/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $285,174

Issue Date FY: 2013 ( Subtotal = $244,168 )
2013	2013	REGENTS, UNIVERSITY OF CALIFORNIA	POST OFFICE BOX 112	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	000	14	3/12/2013	NON-COMPETING CONTINUATION	$227,722
2013	2013	REGENTS, UNIVERSITY OF CALIFORNIA	POST OFFICE BOX 112	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	001	14	6/26/2013	NON-COMPETING CONTINUATION	$16,446
														Subtotal = $244,168

Issue Date FY: 2012 ( Subtotal = $217,147 )
2012	2012	REGENTS, UNIVERSITY OF CALIFORNIA	POST OFFICE BOX 112	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	001	13	3/5/2012	NON-COMPETING CONTINUATION	$257,674
2012	2011	REGENTS, UNIVERSITY OF CALIFORNIA	POST OFFICE BOX 112	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	000	12	12/1/2011	NON-COMPETING CONTINUATION	-$40,527
														Subtotal = $217,147

Issue Date FY: 2011 ( Subtotal = $300,601 )
2011	2011	REGENTS, UNIVERSITY OF CALIFORNIA	POST OFFICE BOX 112	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	001	12	8/15/2011	NON-COMPETING CONTINUATION	$27,328
2011	2011	REGENTS, UNIVERSITY OF CALIFORNIA	POST OFFICE BOX 112	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	000	12	3/11/2011	NON-COMPETING CONTINUATION	$273,273
														Subtotal = $300,601

Issue Date FY: 2010 ( Subtotal = $446,491 )
2010	2010	REGENTS, UNIVERSITY OF CALIFORNIA	POST OFFICE BOX 112	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	000	11	4/1/2010	COMPETING CONTINUATION	$305,081
2010	2010	REGENTS, UNIVERSITY OF CALIFORNIA	POST OFFICE BOX 112	RIVERSIDE	CA	92521	RIVERSIDE	USA	Trans-NIH Recovery Act Research Support	003	11	7/2/2010	SUPPLEMENT FOR EXPANSION	$114,169
2010	2009	REGENTS, UNIVERSITY OF CALIFORNIA	POST OFFICE BOX 112	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	001	10	4/1/2010	NON-COMPETING CONTINUATION	$0
2010	2009	REGENTS, UNIVERSITY OF CALIFORNIA	POST OFFICE BOX 112	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	002	10	4/1/2010	NON-COMPETING CONTINUATION	$27,241
														Subtotal = $446,491

Issue Date FY: 2009 ( Subtotal = $477,151 ) (Continued on the next page)
2009	2009	REGENTS, UNIVERSITY OF CALIFORNIA	POST OFFICE BOX 112	RIVERSIDE	CA	92521	RIVERSIDE	USA	Trans-NIH Recovery Act Research Support	002	10	8/12/2009	SUPPLEMENT FOR EXPANSION	$204,740
2009	2009	REGENTS, UNIVERSITY OF CALIFORNIA	POST OFFICE BOX 112	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	001	10	4/6/2009	NON-COMPETING CONTINUATION	$27,241
Grand Total All Awards = $6,362,587

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Administrative supplement to purchase a plate reader

Award Number: R01GM061146

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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