Friday, December 6, 2024 12/6/2024

Replication Fork Repair

Award Number: R01GM051753
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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View Award Abstract

Project Summary Replication fork repair is essential for cell survival and stability of genetic material. In humans, inefficiency of repair is associated with cancer proneness, neurological, immunological, developmental defects and premature aging. For microbial pathogens, the ability to repair DNA damage is required for survival of bacterial pathogens and promotes genetic change that can contribute to antibiotic resistance and persistence of infection. The long-term goal of our studies is a more complete mechanistic understanding of the repair of replication forks and how it affects genomic stability. This will be accomplished using the genetic system of Escherichia coli, whose physiology is well understood. A central interest is how bacterial cells signal difficulties in replication to facilitate repair and how this is integrated with other aspects of bacterial growth. By biochemical and genetic analysis, this work will elucidate how a newly discovered conserved DNA helicase protein, YoaA, interacts with the replisome to overcome barriers in replication. This study will specifically address the influence of RNA transcription and DNA protein complexes on replication and genomic instability and what mechanisms are used to overcome conflicts between replication and transcription machinery. The regulatory pathway controlled by stringent starvation protein, SspA, will also be explored to discover how it impacts DNA metabolism. Because all cells repair DNA in fundamentally similar ways by evolutionarily related pathways, these studies using microbial model organisms should reveal mechanisms applicable to repair of DNA in human cells. In addition, because the DNA damage response in microbial pathogens plays a role in toxin production, antibiotic resistance and persistence of infection, this work could provide new information important for the treatment of infectious disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $504,582 )
2024	2024	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Biomedical Research and Research Training	000	27	7/31/2024	NON-COMPETING CONTINUATION	$504,582
														Subtotal = $504,582

Issue Date FY: 2023 ( Subtotal = $516,423 )
2023	2023	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Biomedical Research and Research Training	000	25	7/10/2023	SUPPLEMENT FOR EXPANSION	$11,841
2023	2023	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Biomedical Research and Research Training	001	26	7/28/2023	NON-COMPETING CONTINUATION	$504,582
														Subtotal = $516,423

Issue Date FY: 2022 ( Subtotal = $504,582 )
2022	2022	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Biomedical Research and Research Training	001	25	9/2/2022	COMPETING CONTINUATION	$504,582
2022	2019	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Biomedical Research and Research Training	000	24	3/1/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $504,582

Issue Date FY: 2019 ( Subtotal = $578,558 )
2019	2019	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Biomedical Research and Research Training	000	24	9/6/2019	NON-COMPETING CONTINUATION	$488,128
2019	2019	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Biomedical Research and Research Training	001	24	9/9/2019	SUPPLEMENT FOR EXPANSION	$90,430
														Subtotal = $578,558

Issue Date FY: 2018 ( Subtotal = $488,128 )
2018	2018	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Biomedical Research and Research Training	000	23	7/13/2018	NON-COMPETING CONTINUATION	$488,128
														Subtotal = $488,128

Issue Date FY: 2017 ( Subtotal = $488,128 )
2017	2017	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Biomedical Research and Research Training	002	22	7/31/2017	NON-COMPETING CONTINUATION	$488,128
2017	2016	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Biomedical Research and Research Training	001	21	1/28/2017	COMPETING CONTINUATION	$299
2017	2015	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Biomedical Research and Research Training	000	20	1/28/2017	NON-COMPETING CONTINUATION	-$299
														Subtotal = $488,128

Issue Date FY: 2016 ( Subtotal = $522,128 )
2016	2016	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Biomedical Research and Research Training	001	21	9/9/2016	COMPETING CONTINUATION	$522,128
2016	2015	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	022549110		USA	Biomedical Research and Research Training	000	20	9/7/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $522,128

Issue Date FY: 2015 ( Subtotal = $490,253 )
2015	2015	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Biomedical Research and Research Training	001	20	2/2/2015	NON-COMPETING CONTINUATION	$49,026
2015	2015	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Biomedical Research and Research Training	000	20	12/16/2014	NON-COMPETING CONTINUATION	$441,227
														Subtotal = $490,253

Issue Date FY: 2014 ( Subtotal = $488,748 )
2014	2014	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Biomedical Research and Research Training	001	19	4/2/2014	NON-COMPETING CONTINUATION	$48,875
2014	2014	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Biomedical Research and Research Training	000	19	12/25/2013	NON-COMPETING CONTINUATION	$439,873
														Subtotal = $488,748

Issue Date FY: 2013 ( Subtotal = $470,190 )
2013	2013	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Biomedical Research and Research Training	001	18	6/24/2013	NON-COMPETING CONTINUATION	$31,671
2013	2013	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Biomedical Research and Research Training	000	18	12/17/2012	NON-COMPETING CONTINUATION	$438,519
														Subtotal = $470,190

Issue Date FY: 2012 ( Subtotal = $519,110 )
2012	2012	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Biomedical Research and Research Training	001	17	1/9/2012	COMPETING CONTINUATION	$519,110
2012	2011	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Biomedical Research and Research Training	000	16	1/9/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $519,110

Issue Date FY: 2011 ( Subtotal = $529,735 )
2011	2011	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Biomedical Research and Research Training	001	16	7/18/2011	NON-COMPETING CONTINUATION	$33,710
2011	2011	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Biomedical Research and Research Training	000	16	11/26/2010	NON-COMPETING CONTINUATION	$496,025
														Subtotal = $529,735

Issue Date FY: 2010 ( Subtotal = $535,900 )
2010	2010	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Biomedical Research and Research Training	001	15	3/17/2010	NON-COMPETING CONTINUATION	$48,718
2010	2010	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Biomedical Research and Research Training	000	15	11/23/2009	NON-COMPETING CONTINUATION	$487,182
														Subtotal = $535,900

Issue Date FY: 2009 ( Subtotal = $526,052 )
2009	2009	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Biomedical Research and Research Training	001	14	3/25/2009	NON-COMPETING CONTINUATION	$52,605
2009	2009	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Biomedical Research and Research Training	000	14	11/13/2008	NON-COMPETING CONTINUATION	$473,447
														Subtotal = $526,052

Issue Date FY: 2008 ( Subtotal = $512,417 )
2008	2008	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Biomedical Research and Research Training	000	13	12/3/2007	COMPETING CONTINUATION	$512,417
														Subtotal = $512,417

Issue Date FY: 2007 ( Subtotal = $126,486 )
2007	2007	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Biomedical Research and Research Training	001	12	2/26/2007	SUPPLEMENT FOR EXPANSION	$126,486
														Subtotal = $126,486

Issue Date FY: 2006 ( Subtotal = $379,742 )
2006	2006	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Biomedical Research and Research Training	000	12	3/2/2006	NON-COMPETING CONTINUATION	$379,742
														Subtotal = $379,742

Issue Date FY: 2005 ( Subtotal = $377,645 )
2005	2005	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Biomedical Research and Research Training	000	11	3/23/2005	NON-COMPETING CONTINUATION	$377,645
														Subtotal = $377,645

Issue Date FY: 2004 ( Subtotal = $366,736 ) (Continued on the next page)
Grand Total All Awards = $10,536,849

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Replication Fork Repair

Award Number: R01GM051753

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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