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Binding, Sliding and Function of Cohesin on Sister Chromatids

Award Number: R01GM051402
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/12/1994
PERIOD OF PERFORMANCE END DATE: 02/28/2025

Group Awards By:

View Award Description

Binding, Sliding and Function of Cohesin on Sister Chromatids - PI: Gartenberg, Marc R. PROJECT SUMMARY Cohesin organizes eukaryotic genomes into structures that segregate faithfully between dividing cells. The complex keeps newly replicated sister chromatids together and folds individual chromatids into compact chromosomal structures. Cohesin accomplishes these tasks by holding distant DNA sites in close proximity. Defects in cohesin or cohesin regulators have been linked to cancer and are the cause of developmental diseases known collectively as cohesinopathies. Thus, understanding how cohesin functions will reveal much about chromosome structure as it relates to human health. Cohesin complexes bind numerous chromosomal sites by encircling the DNA of each site in a topological embrace. Many cohesin binding sites lie in and around genes. When the genes are expressed, cohesin must move out of the way of advancing RNA polymerases. How this occurs is not clear. The central goal of this proposal is to understand how cohesin moves on chromosomal arms to adopt positions that achieve structural roles yet permit proper gene expression. The Gartenberg lab recently showed that cohesin translocates on DNA by sliding, and that the complex remains cohesive while in motion. Using yeast as a model system, this proposal aims to determine how the dynamic distribution of cohesin on chromosomal DNA is determined by binding, sliding and function of the complex. Aim 1 uses novel, molecular biology assays to define the dimensions of the DNA channel through cohesin, as well as determine whether the complex embraces one or two chromatids within the same channel. The experiments will determine how the dimensions of the complex limit which obstacles the complex can slide past. Aim 2 uses molecular biology assays to determine how transcription and other ATP-dependent processes regulate cohesin movement, and define the biological consequences when movement is blocked. The experiments will determine the molecular basis and physiological benefit of cohesin accumulating at specific cohesin enrichment sites. Aim 3 uses genome-scale strategies to distinguish between chromosomal sites where cohesin holds sister chromatids together and where it does not. The experiments will yield the first comprehensive maps of cohesin based on the functionality of the complex.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	RUTGERS, THE STATE UNIVERSITY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Biomedical Research and Research Training	000	24	6/6/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Biomedical Research and Research Training	000	24	1/4/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $387,357 )
2022	2022	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Biomedical Research and Research Training	001	24	6/9/2022	NON-COMPETING CONTINUATION	$38,736
2022	2022	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Biomedical Research and Research Training	000	24	2/16/2022	NON-COMPETING CONTINUATION	$348,621
														Subtotal = $387,357

Issue Date FY: 2021 ( Subtotal = $387,319 )
2021	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Biomedical Research and Research Training	000	23	2/17/2021	NON-COMPETING CONTINUATION	$387,319
														Subtotal = $387,319

Issue Date FY: 2020 ( Subtotal = $387,281 )
2020	2020	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Biomedical Research and Research Training	000	22	2/13/2020	NON-COMPETING CONTINUATION	$387,281
														Subtotal = $387,281

Issue Date FY: 2019 ( Subtotal = $416,148 )
2019	2019	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Biomedical Research and Research Training	002	21	7/23/2019	SUPPLEMENT FOR EXPANSION	$28,903
2019	2019	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Biomedical Research and Research Training	001	21	4/26/2019	COMPETING CONTINUATION	$387,245
2019	2015	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Biomedical Research and Research Training	003	20	9/19/2019	NON-COMPETING CONTINUATION	$0
2019	2015	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Biomedical Research and Research Training	000	20	4/23/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $416,148

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2015	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Biomedical Research and Research Training	000	20	5/16/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Biomedical Research and Research Training	000	20	5/11/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $450,869 )
2015	2015	Rutgers, The State Univ Biomedical & Health Sciences	65 Davidson Road	Piscataway	NJ	08854	MIDDLESEX	USA	Biomedical Research and Research Training	000	20	6/29/2015	NON-COMPETING CONTINUATION	$450,869
														Subtotal = $450,869

Issue Date FY: 2014 ( Subtotal = $450,869 )
2014	2014	Rutgers, The State Univ Biomedical & Health Sciences	65 Davidson Road	Piscataway	NJ	08854	MIDDLESEX	USA	Biomedical Research and Research Training	000	19	7/11/2014	NON-COMPETING CONTINUATION	$450,869
														Subtotal = $450,869

Issue Date FY: 2013 ( Subtotal = $435,089 )
2013	2013	Rutgers, The State Univ Biomedical & HEALTH Sciences	65 Davidson Road	Piscataway	NJ	08554		USA	Biomedical Research and Research Training	000	18	8/1/2013	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$435,089
														Subtotal = $435,089

Issue Date FY: 2012 ( Subtotal = $448,157 )
2012	2012	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Biomedical Research and Research Training	000	17	6/25/2012	COMPETING CONTINUATION	$448,157
														Subtotal = $448,157

Issue Date FY: 2011 ( Subtotal = $0 )
2011	2010	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Trans-NIH Recovery Act Research Support	000	15	3/2/2011	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2010 ( Subtotal = $498,046 )
2010	2010	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Trans-NIH Recovery Act Research Support	000	15	12/18/2009	SUPPLEMENT FOR EXPANSION	$53,240
2010	2010	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Biomedical Research and Research Training	001	16	6/30/2010	NON-COMPETING CONTINUATION	$444,806
														Subtotal = $498,046

Issue Date FY: 2009 ( Subtotal = $436,211 )
2009	2009	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Biomedical Research and Research Training	000	15	6/10/2009	NON-COMPETING CONTINUATION	$436,211
														Subtotal = $436,211

Issue Date FY: 2008 ( Subtotal = $423,508 )
2008	2008	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Biomedical Research and Research Training	000	14	6/20/2008	NON-COMPETING CONTINUATION	$423,508
														Subtotal = $423,508

Issue Date FY: 2007 ( Subtotal = $468,453 )
2007	2007	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Biomedical Research and Research Training	000	13	6/29/2007	COMPETING CONTINUATION	$468,453
														Subtotal = $468,453

Issue Date FY: 2006 ( Subtotal = $427,082 )
2006	2006	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Biomedical Research and Research Training	000	12	6/23/2006	NON-COMPETING CONTINUATION	$427,082
														Subtotal = $427,082

Issue Date FY: 2005 ( Subtotal = $424,742 )
2005	2005	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Biomedical Research and Research Training	000	11	7/4/2005	NON-COMPETING CONTINUATION	$424,742
														Subtotal = $424,742

Issue Date FY: 2004 ( Subtotal = $412,494 )
2004	2004	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Biomedical Research and Research Training	001	10	8/30/2004	SUPPLEMENT FOR EXPANSION	$43,074
2004	2004	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Biomedical Research and Research Training	000	10	6/14/2004	NON-COMPETING CONTINUATION	$369,420
														Subtotal = $412,494

Issue Date FY: 2003 ( Subtotal = $478,751 )
2003	2003	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Genetics and Developmental Biology Research and Research Training	000	9	6/20/2003	COMPETING CONTINUATION	$478,751
														Subtotal = $478,751

Issue Date FY: 2002 ( Subtotal = $318,070 )
2002	2002	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Genetics and Developmental Biology Research and Research Training	000	8	5/16/2002	NON-COMPETING CONTINUATION	$318,070
														Subtotal = $318,070

Grand Total All Awards = $8,384,585

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Binding, Sliding and Function of Cohesin on Sister Chromatids

Award Number: R01GM051402

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/12/1994

PERIOD OF PERFORMANCE END DATE: 02/28/2025

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