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INSECTICIDE RESISTANCE:CYP6D1 REGULATION AND ALLELES

Award Number: R01GM047835
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/1992
PERIOD OF PERFORMANCE END DATE: 03/31/2006

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INSECTICIDE RESISTANCE:CYP6D1 REGULATION AND ALLELES - DESCRIPTION: (provided by the applicant): Dipteran insects act as vectors for a large number of human diseases. Currently pyrethroids are one of the most widely used classes of insecticides for insect control. However, a major limitation with the use of insecticides for vector control is the development of resistance. An important mechanism by which insects become resistant to pyrethroid insecticides is through enhanced detoxification effected by increased activity of the cytochrome P450 microsomal monooxygenases. These monooxygenases are an extremely important metabolic system capable of metabolizing a wide range of compounds due to the presence of several different cytochrome P450 isoforms. CYP6D1 is the P450 responsible for high levels of monooxygenase-mediated pyrethroid resistance in the LPR strain of housefly. CYPGD1-mediated resistance is due to an elevated level of this protein in the resistant strain. The underlying basis for this elevated level is an increased rate of CYP6D1v1 transcription in the LPR strain. The objectives of the proposed research are 1) to identify the CYP6D1 regulatory elements involved in insecticide resistance (i.e., those responsible for the increased transcription) and 2) to examine if the different CYP6D1 alleles found in resistant and susceptible strains have a role in resistance. The proposed research will provide an unprecedented understanding of CYP6D1-mediated pyrethroid resistance specifically, and the molecular basis of monooxygenase-mediated resistance in general. The ultimate goal of this research is to discover ways to delay the development of monooxygenase-mediated pyrethroid resistance.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2005 ( Subtotal = $278,250 )
2005	2005	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	12	2/18/2005	NON-COMPETING CONTINUATION	$278,250
														Subtotal = $278,250

Issue Date FY: 2004 ( Subtotal = $278,250 )
2004	2004	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	11	2/9/2004	NON-COMPETING CONTINUATION	$278,250
														Subtotal = $278,250

Issue Date FY: 2003 ( Subtotal = $278,250 )
2003	2003	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	10		NON-COMPETING CONTINUATION	$278,250
														Subtotal = $278,250

Issue Date FY: 2002 ( Subtotal = $278,250 )
2002	2002	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	9	2/18/2002	COMPETING CONTINUATION	$278,250
														Subtotal = $278,250

Issue Date FY: 2000 ( Subtotal = $200,158 )
2000	2000	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	9	3/27/2000	NON-COMPETING CONTINUATION	$200,158
														Subtotal = $200,158

Issue Date FY: 1999 ( Subtotal = $194,423 )
1999	1999	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	7	4/1/1999	NON-COMPETING CONTINUATION	$194,423
														Subtotal = $194,423

Issue Date FY: 1998 ( Subtotal = $201,489 )
1998	1998	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	6	3/17/1998	COMPETING CONTINUATION	$201,489
														Subtotal = $201,489

Grand Total All Awards = $1,709,070

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INSECTICIDE RESISTANCE:CYP6D1 REGULATION AND ALLELES

Award Number: R01GM047835

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/1992

PERIOD OF PERFORMANCE END DATE: 03/31/2006

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