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ECF Sigma Factors and Cell Envelope Stress in Bacillus subtilis

Award Number: R01GM047446
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/1992
PERIOD OF PERFORMANCE END DATE: 05/31/2018

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ECF Sigma Factors and Cell Envelope Stress in Bacillus subtilis - DESCRIPTION (provided by applicant): This proposal investigates cell envelope stress responses in Bacillus subtilis, a model organism for the Gram positive bacteria. Antibiotics and other agents that impair the synthesis or function of the cell membrane or peptidoglycan cell wall are of critical importance in clinical medicine. Exposure to sub-lethal levels of antibiotics activates the transcription of sets of genes (cell envelope stress responses) that serve to remodel the cell wall and membrane. In B. subtilis, these stress responses are coordinated by alternative sigma subunits for RNA polymerase of the extracytoplasmic function (ECF) subfamily. This proposal is focused on defining the role of ECF sigma factors in controlling adaptive changes in cell envelope function. One focus will be on the roles of induced lipid biosynthesis pathways and proteins in the genesis and function of lipid rafts. A second focus will be to discover the roles of a newly defined second messenger, cyclic-di-AMP, that is required for cell envelope homeostasis. Using a combination of classical and molecular genetics, genomics, transcriptomics, and biochemical approaches, these studies will provide insights into cell envelope synthesis and function, and reveal novel mechanisms of antibiotic resistance.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2016	CORNELL UNIVERSITY, INC	373 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	24	9/24/2018	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $479,575 )
2016	2016	CORNELL UNIVERSITY	373 PINE ROAD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	24	5/4/2016	EXTENSION WITH OR WITHOUT FUNDS	$479,575
														Subtotal = $479,575

Issue Date FY: 2015 ( Subtotal = $479,575 )
2015	2015	CORNELL UNIVERSITY	373 PINE ROAD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	23	5/18/2015	NON-COMPETING CONTINUATION	$479,575
														Subtotal = $479,575

Issue Date FY: 2014 ( Subtotal = $479,575 )
2014	2014	CORNELL UNIVERSITY	373 PINE ROAD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	22	5/21/2014	NON-COMPETING CONTINUATION	$479,575
														Subtotal = $479,575

Issue Date FY: 2013 ( Subtotal = $479,576 )
2013	2013	CORNELL UNIVERSITY	373 PINE ROAD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	001	21	7/22/2013	COMPETING CONTINUATION	$479,576
2013	2012	CORNELL UNIVERSITY	373 PINE ROAD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	20	7/17/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $479,576

Issue Date FY: 2012 ( Subtotal = $450,595 )
2012	2012	CORNELL UNIVERSITY	373 PINE ROAD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	20	1/6/2012	NON-COMPETING CONTINUATION	$410,333
2012	2012	CORNELL UNIVERSITY	373 PINE ROAD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	001	20	3/9/2012	NON-COMPETING CONTINUATION	$40,262
														Subtotal = $450,595

Issue Date FY: 2011 ( Subtotal = $450,516 )
2011	2011	CORNELL UNIVERSITY	373 PINE ROAD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	19	12/22/2010	NON-COMPETING CONTINUATION	$421,847
2011	2011	CORNELL UNIVERSITY	373 PINE ROAD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	001	19	6/29/2011	NON-COMPETING CONTINUATION	$28,669
														Subtotal = $450,516

Issue Date FY: 2010 ( Subtotal = $458,463 )
2010	2010	CORNELL UNIVERSITY	373 PINE ROAD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	18	2/8/2010	NON-COMPETING CONTINUATION	$458,463
														Subtotal = $458,463

Issue Date FY: 2009 ( Subtotal = $453,035 )
2009	2009	CORNELL UNIVERSITY	373 PINE ROAD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	17	12/25/2008	COMPETING CONTINUATION	$453,035
														Subtotal = $453,035

Issue Date FY: 2008 ( Subtotal = $446,340 )
2008	2008	CORNELL UNIVERSITY, ENDOWED COLLEGES	EAST HILL PLAZA	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	16	12/17/2007	NON-COMPETING CONTINUATION	$446,340
														Subtotal = $446,340

Issue Date FY: 2007 ( Subtotal = $446,723 )
2007	2007	CORNELL UNIVERSITY, ENDOWED COLLEGES	EAST HILL PLAZA	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	15	1/1/2007	NON-COMPETING CONTINUATION	$446,723
														Subtotal = $446,723

Issue Date FY: 2006 ( Subtotal = $446,752 )
2006	2006	CORNELL UNIVERSITY, ENDOWED COLLEGES	EAST HILL PLAZA	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	14	1/17/2006	NON-COMPETING CONTINUATION	$446,752
														Subtotal = $446,752

Issue Date FY: 2005 ( Subtotal = $467,968 )
2005	2005	CORNELL UNIVERSITY, ENDOWED COLLEGES	EAST HILL PLAZA	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	13	12/27/2004	COMPETING CONTINUATION	$467,968
														Subtotal = $467,968

Issue Date FY: 2004 ( Subtotal = $278,250 )
2004	2004	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	12	12/11/2003	NON-COMPETING CONTINUATION	$278,250
														Subtotal = $278,250

Issue Date FY: 2003 ( Subtotal = $278,250 )
2003	2003	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Genetics and Developmental Biology Research and Research Training	000	11		NON-COMPETING CONTINUATION	$278,250
														Subtotal = $278,250

Issue Date FY: 2002 ( Subtotal = $278,250 )
2002	2002	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Genetics and Developmental Biology Research and Research Training	000	10	12/12/2001	NON-COMPETING CONTINUATION	$278,250
														Subtotal = $278,250

Issue Date FY: 2001 ( Subtotal = $278,250 )
2001	2001	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Genetics and Developmental Biology Research and Research Training	000	9	2/1/2001	COMPETING CONTINUATION	$278,250
														Subtotal = $278,250

Issue Date FY: 1999 ( Subtotal = $171,146 )
1999	1999	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Genetics and Developmental Biology Research and Research Training	000	8	4/5/1999	NON-COMPETING CONTINUATION	$171,146
														Subtotal = $171,146

Issue Date FY: 1998 ( Subtotal = $166,363 )
1998	1998	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Genetics and Developmental Biology Research and Research Training	000	7	4/10/1998	NON-COMPETING CONTINUATION	$166,363
														Subtotal = $166,363

Grand Total All Awards = $6,989,202

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ECF Sigma Factors and Cell Envelope Stress in Bacillus subtilis

Award Number: R01GM047446

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/1992

PERIOD OF PERFORMANCE END DATE: 05/31/2018

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