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New Concepts In Organic Selectivity and Mechanisms

Award Number: R01GM045617
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary / Abstract The conventional framework for understanding reactivity and selectivity in organic reactions fails for reactions influenced by dynamic effects. It is proposed to investigate the role of dynamic effects in some of the most common and important reactions in chemistry. Our work with dynamic effects in sigmatropic rearrangements has recently led to a successful strategy for the control of selectivity in these reactions. We plan to extend this strategy to cover a broad array of reactions and develop catalytically enantioselective sigmatropic rearrangements. Another new emphasis in our research is the role of solvent dynamics in reactions. Following up on recent results with the Wittig reaction and arene nitration, we will develop an understanding of how solvent dynamics affects experimental observations in a series of polar reactions. Alkoxy radical cleavage reactions give us a rare opportunity to vary on a near continuum barriers, structure, and excess energy to examine the rules that govern the onset and degree of dynamic effects. Alkoxy radicals are important to broad areas of chemistry, and we aim to understand how dynamics affects their reactions. Following on our prior work with hydroboration and ozonolysis, we aim to examine the reactions induced by the generation of extremely “hot” intermediates or products in ordinary reactions. The health-relatedness of this work derives from its impact on both strategies to control reaction selectivity and the understanding of reactions important in the synthesis of medicinally important substances and reactions important in biological pathways.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	000	27	7/30/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $277,165 )
2019	2019	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	000	27	3/13/2019	NON-COMPETING CONTINUATION	$277,165
														Subtotal = $277,165

Issue Date FY: 2018 ( Subtotal = $278,110 )
2018	2018	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	000	26	3/12/2018	NON-COMPETING CONTINUATION	$250,299
2018	2018	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	001	26	5/23/2018	NON-COMPETING CONTINUATION	$27,811
														Subtotal = $278,110

Issue Date FY: 2017 ( Subtotal = $279,009 )
2017	2017	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	003	25	6/2/2017	NON-COMPETING CONTINUATION	$27,901
2017	2017	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	000	25	3/28/2017	NON-COMPETING CONTINUATION	$251,108
2017	2016	TEXAS A & M RESEARCH FOUNDATION	400 HARVEY MITCHELL PKWY STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	002	23	4/10/2017	SUPPLEMENT FOR EXPANSION	$0
2017	2014	TEXAS A & M RESEARCH FOUNDATION	400 HARVEY MITCHELL PKWY STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	001	23	4/8/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $279,009

Issue Date FY: 2016 ( Subtotal = $279,866 )
2016	2016	TEXAS A & M RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	003	23	8/11/2016	SUPPLEMENT FOR EXPANSION	$0
2016	2016	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PARKWAY	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	004	24	8/11/2016	COMPETING CONTINUATION	$188,078
2016	2016	TEXAS A & M RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	000	23	11/27/2015	SUPPLEMENT FOR EXPANSION	$91,788
2016	2014	TEXAS A & M RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	002	23	8/11/2016	NON-COMPETING CONTINUATION	$0
2016	2014	TEXAS A & M RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	001	23	11/27/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $279,866

Issue Date FY: 2014 ( Subtotal = $272,091 )
2014	2014	TEXAS A & M RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	000	23	3/19/2014	NON-COMPETING CONTINUATION	$272,091
														Subtotal = $272,091

Issue Date FY: 2013 ( Subtotal = $262,568 )
2013	2013	TEXAS A & M RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	001	22	6/20/2013	NON-COMPETING CONTINUATION	$17,686
2013	2013	TEXAS A & M RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	000	22	3/21/2013	NON-COMPETING CONTINUATION	$244,882
														Subtotal = $262,568

Issue Date FY: 2012 ( Subtotal = $272,091 )
2012	2012	TEXAS A & M RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	000	21	3/22/2012	NON-COMPETING CONTINUATION	$272,091
														Subtotal = $272,091

Issue Date FY: 2011 ( Subtotal = $272,091 )
2011	2011	TEXAS A & M RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	001	20	3/28/2011	COMPETING CONTINUATION	$272,091
2011	2010	TEXAS A & M RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	000	19	3/24/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $272,091

Issue Date FY: 2010 ( Subtotal = $246,239 )
2010	2010	TEXAS A & M RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	000	19	11/16/2009	NON-COMPETING CONTINUATION	$223,853
2010	2010	TEXAS A & M RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	001	19	2/23/2010	NON-COMPETING CONTINUATION	$22,386
														Subtotal = $246,239

Issue Date FY: 2009 ( Subtotal = $249,110 )
2009	2009	TEXAS A & M RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	001	18	4/7/2009	NON-COMPETING CONTINUATION	$24,911
2009	2009	TEXAS A & M RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	000	18	11/21/2008	NON-COMPETING CONTINUATION	$224,199
														Subtotal = $249,110

Issue Date FY: 2008 ( Subtotal = $249,483 )
2008	2008	TEXAS A & M UNIVERSITY RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	000	17	11/15/2007	NON-COMPETING CONTINUATION	$249,483
														Subtotal = $249,483

Issue Date FY: 2007 ( Subtotal = $269,844 )
2007	2007	TEXAS A & M UNIVERSITY RESEARCH FOUNDATION	POST OFFICE BOX 3578	COLLEGE STATION	TX	77843	BRAZOS	USA	Biomedical Research and Research Training	000	16	12/1/2006	COMPETING CONTINUATION	$269,844
														Subtotal = $269,844

Issue Date FY: 2006 ( Subtotal = $227,329 )
2006	2006	TEXAS A & M UNIVERSITY RESEARCH FOUNDATION	POST OFFICE BOX 3578	COLLEGE STATION	TX	77843	BRAZOS	USA	Biomedical Research and Research Training	000	15	11/30/2005	NON-COMPETING CONTINUATION	$227,329
														Subtotal = $227,329

Issue Date FY: 2005 ( Subtotal = $232,458 )
2005	2005	TEXAS A & M UNIVERSITY RESEARCH FOUNDATION	POST OFFICE BOX 3578	COLLEGE STATION	TX	77843	BRAZOS	USA	Biomedical Research and Research Training	000	14	11/18/2004	NON-COMPETING CONTINUATION	$232,458
														Subtotal = $232,458

Issue Date FY: 2004 ( Subtotal = $232,800 )
2004	2004	TEXAS A & M UNIVERSITY RESEARCH FOUNDATION	POST OFFICE BOX 3578	COLLEGE STATION	TX	77843	BRAZOS	USA	Biomedical Research and Research Training	000	13	11/27/2003	COMPETING CONTINUATION	$232,800
														Subtotal = $232,800

Issue Date FY: 2002 ( Subtotal = $195,550 )
2002	2002	TEXAS A & M UNIVERSITY RESEARCH FOUNDATION	POST OFFICE BOX 3578	COLLEGE STATION	TX	77843	BRAZOS	USA	Biomedical Research and Research Training	000	12	6/28/2002	NON-COMPETING CONTINUATION	$195,550
														Subtotal = $195,550

Issue Date FY: 2001 ( Subtotal = $195,550 )
2001	2001	TEXAS A & M UNIVERSITY RESEARCH FOUNDATION	POST OFFICE BOX 3578	COLLEGE STATION	TX	77843	BRAZOS	USA	Biomedical Research and Research Training	000	11	7/2/2001	NON-COMPETING CONTINUATION	$195,550
														Subtotal = $195,550

Issue Date FY: 2000 ( Subtotal = $192,799 )
2000	2000	TEXAS A & M RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	000	10	6/25/2000	COMPETING CONTINUATION	$192,799
														Subtotal = $192,799

Grand Total All Awards = $4,765,130

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New Concepts In Organic Selectivity and Mechanisms

Award Number: R01GM045617

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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