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Initiation of DNA Replication at Cell Origins in Yeast

Award Number: R01GM045436
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/1991
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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View Award Description

Initiation of DNA Replication at Cell Origins in Yeast - The goal of this research is to determine the mechanism and regulation of the initiation of DNA replication in eukaryotic cells. It is clear that for maintenance of the integrity of the genome from one cell generation to the next, DNA and its associated chromatin structures must be duplicated in a highly controlled and accurate manner. Interruption of these controls may promote genome instability and lead to neoplastic transformation in somatic cells or result in mutations in the germ line that can cause many different disorders. Moreover, the DNA replication proteins represent tangible targets for therapeutic intervention and diagnosis of proliferation of cancer cells and other proliferative disorders. The initiator protein (ORC) cooperates with a series of DNA replication proteins, including Cdc6, Cdt1 and the MCM2-7 hexamer to establish at origins of DNA replication a pre-Replicative Complex (pre-RC) that facilitates later initiation of DNA synthesis at each origin. Recent progress has determined the mechanism of assembly of the pre-RC and the structure of its components. The proposed research in this application will investigate, using proteins from multiple yeast species and human cells, how origins of DNA replication are specified in these diverse genomes. One of them, the yeast S. cerevisiae has DNA sequence specific origins but the others do not; therefore we propose to determine how these other eukaryotes specify and control DNA replication origins.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $751,488 )
2025	2025	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPG HBR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	000	32	5/28/2025	NON-COMPETING CONTINUATION	$751,488
														Subtotal = $751,488

Issue Date FY: 2024 ( Subtotal = $751,488 )
2024	2024	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPG HBR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	000	31	5/13/2024	NON-COMPETING CONTINUATION	$751,488
														Subtotal = $751,488

Issue Date FY: 2023 ( Subtotal = $751,488 )
2023	2023	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	000	30	5/18/2023	NON-COMPETING CONTINUATION	$751,488
														Subtotal = $751,488

Issue Date FY: 2022 ( Subtotal = $751,488 )
2022	2022	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	000	29	7/25/2022	COMPETING CONTINUATION	$751,488
2022	2020	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	001	28	8/28/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $751,488

Issue Date FY: 2020 ( Subtotal = $729,600 )
2020	2020	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	000	28	3/6/2020	NON-COMPETING CONTINUATION	$729,600
														Subtotal = $729,600

Issue Date FY: 2019 ( Subtotal = $729,600 )
2019	2019	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	000	27	1/31/2019	NON-COMPETING CONTINUATION	$729,600
														Subtotal = $729,600

Issue Date FY: 2018 ( Subtotal = $729,600 )
2018	2018	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	001	26	5/30/2018	NON-COMPETING CONTINUATION	$72,958
2018	2018	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	000	26	1/24/2018	NON-COMPETING CONTINUATION	$656,642
														Subtotal = $729,600

Issue Date FY: 2017 ( Subtotal = $729,600 )
2017	2017	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	001	25	2/27/2017	COMPETING CONTINUATION	$729,600
2017	2015	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	002	24	8/16/2017	NON-COMPETING CONTINUATION	$0
2017	2015	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	000	24	2/27/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $729,600

Issue Date FY: 2016 ( Subtotal = $190,000 )
2016	2016	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Biomedical Research and Research Training	000	24	8/9/2016	SUPPLEMENT FOR EXPANSION	$190,000
														Subtotal = $190,000

Issue Date FY: 2015 ( Subtotal = $711,848 )
2015	2015	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Biomedical Research and Research Training	000	24	6/29/2015	NON-COMPETING CONTINUATION	$711,848
														Subtotal = $711,848

Issue Date FY: 2014 ( Subtotal = $700,725 )
2014	2014	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Biomedical Research and Research Training	000	23	5/29/2014	NON-COMPETING CONTINUATION	$700,725
														Subtotal = $700,725

Issue Date FY: 2013 ( Subtotal = $676,199 )
2013	2013	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Biomedical Research and Research Training	000	22	5/22/2013	NON-COMPETING CONTINUATION	$676,199
														Subtotal = $676,199

Issue Date FY: 2012 ( Subtotal = $696,400 )
2012	2012	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Biomedical Research and Research Training	000	21	5/17/2012	COMPETING CONTINUATION	$696,400
														Subtotal = $696,400

Issue Date FY: 2011 ( Subtotal = $638,144 )
2011	2011	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Biomedical Research and Research Training	000	20	6/2/2011	NON-COMPETING CONTINUATION	$638,144
														Subtotal = $638,144

Issue Date FY: 2010 ( Subtotal = $644,890 )
2010	2010	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Biomedical Research and Research Training	000	19	5/20/2010	NON-COMPETING CONTINUATION	$644,890
														Subtotal = $644,890

Issue Date FY: 2009 ( Subtotal = $610,717 )
2009	2009	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Biomedical Research and Research Training	000	18	5/13/2009	NON-COMPETING CONTINUATION	$610,717
														Subtotal = $610,717

Issue Date FY: 2008 ( Subtotal = $602,420 )
2008	2008	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Biomedical Research and Research Training	000	17	5/26/2008	COMPETING CONTINUATION	$602,420
														Subtotal = $602,420

Issue Date FY: 2007 ( Subtotal = $559,923 )
2007	2007	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Biomedical Research and Research Training	000	16	5/7/2007	NON-COMPETING CONTINUATION	$559,923
														Subtotal = $559,923

Issue Date FY: 2006 ( Subtotal = $562,712 )
2006	2006	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Biomedical Research and Research Training	000	15	5/15/2006	NON-COMPETING CONTINUATION	$562,712
														Subtotal = $562,712

Issue Date FY: 2005 ( Subtotal = $562,401 )
2005	2005	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Biomedical Research and Research Training	000	14	5/16/2005	NON-COMPETING CONTINUATION	$562,401
														Subtotal = $562,401

Issue Date FY: 2004 ( Subtotal = $555,907 )
2004	2004	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Biomedical Research and Research Training	000	13	4/30/2004	COMPETING CONTINUATION	$555,907
														Subtotal = $555,907

Issue Date FY: 2003 ( Subtotal = $552,156 )
2003	2003	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Genetics and Developmental Biology Research and Research Training	000	12		NON-COMPETING CONTINUATION	$552,156
														Subtotal = $552,156

Issue Date FY: 2002 ( Subtotal = $536,168 )
2002	2002	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Genetics and Developmental Biology Research and Research Training	000	11	5/27/2002	NON-COMPETING CONTINUATION	$536,168
														Subtotal = $536,168

Grand Total All Awards = $16,819,083

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Initiation of DNA Replication at Cell Origins in Yeast

Award Number: R01GM045436

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/1991

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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