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INTERACTIONS BETWEEN AGROBACTERIUM AND HOST PLANTS

Award Number: R01GM042893
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/1989
PERIOD OF PERFORMANCE END DATE: 06/30/2012

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INTERACTIONS BETWEEN AGROBACTERIUM AND HOST PLANTS - DESCRIPTION (provided by applicant): The goal of this laboratory is continue to the develop the Agrobacterium-plant pathosystem as a leading model for host-microbe interactions and for pheromone-mediated bacterial communication. In the past 15 years, cell-cell communication via diffusible chemical signals has come to be appreciated as an important property of many bacteria, especially those associated with plant, animal, or human hosts. Among these signals, acyl-homoserine lactones (AHLs) are especially widespread among the proteobacteria. AHLs are generally synthesized by proteins resembling the Luxl protein of Vibrio fischeri, and detected by transcription factors resembling the V. ficsheri LuxR protein. My lab focuses on genetic and biochemical studies of several LuxR-type proteins. One of these systems, Tral and TraR of Agrobacterium tumefaciens regulate genes required for the conjugation and vegetative replication of a large tumor-inducing plasmid. Cepl and CepR of Burkholderia cenocepacia regulate many genes on several chromosomes and plasmid of this bacterium, while Yenl and YenR of Yersinia enterocolitica regulate an unknown number of genes, including yenS, which appears to encode a small regulatory RNA. We will continue to test the hypothesis that TraR and CepR require AHL for correct folding, and must bind this pheromone during their own synthesis on ribosomes. We will also study how the activating region or regions of TraR interact with RNA polymerase. We will identify target genes activated by CepR and YenR. YenR is unusual in that it is active as an apo-protein and its activity is inhibited by AHLs. We will try to reconstitute this inhibition in vitro. Finally, we will test the idea that yenS encodes a small non-coding RNA and determine whether this sRNA regulates the stability of target mRNAs by forming heteroduplexes. Direct targets of YenR and YenS will be identified and assessed for their roles in the biology and ecology of Y. enterocolitica and Y. pestis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2011 ( Subtotal = $0 )
2011	2010	CORNELL UNIVERSITY	373 PINE ROAD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	21	7/20/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2010 ( Subtotal = $463,671 )
2010	2010	CORNELL UNIVERSITY	373 PINE ROAD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	21	6/8/2010	NON-COMPETING CONTINUATION	$463,671
														Subtotal = $463,671

Issue Date FY: 2009 ( Subtotal = $454,938 )
2009	2009	CORNELL UNIVERSITY	373 PINE ROAD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	20	6/18/2009	NON-COMPETING CONTINUATION	$454,938
														Subtotal = $454,938

Issue Date FY: 2008 ( Subtotal = $441,902 )
2008	2008	CORNELL UNIVERSITY, ENDOWED COLLEGES	EAST HILL PLAZA	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	19	7/7/2008	NON-COMPETING CONTINUATION	$441,902
														Subtotal = $441,902

Issue Date FY: 2007 ( Subtotal = $459,027 )
2007	2007	CORNELL UNIVERSITY, ENDOWED COLLEGES	EAST HILL PLAZA	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	18	6/25/2007	COMPETING CONTINUATION	$459,027
														Subtotal = $459,027

Issue Date FY: 2006 ( Subtotal = $336,835 )
2006	2006	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	17	3/3/2006	NON-COMPETING CONTINUATION	$336,835
														Subtotal = $336,835

Issue Date FY: 2005 ( Subtotal = $345,739 )
2005	2005	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	16	2/28/2005	NON-COMPETING CONTINUATION	$345,739
														Subtotal = $345,739

Issue Date FY: 2004 ( Subtotal = $343,793 )
2004	2004	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	15	3/5/2004	NON-COMPETING CONTINUATION	$343,793
														Subtotal = $343,793

Issue Date FY: 2003 ( Subtotal = $344,531 )
2003	2003	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Genetics and Developmental Biology Research and Research Training	000	14		COMPETING CONTINUATION	$344,531
														Subtotal = $344,531

Issue Date FY: 2002 ( Subtotal = $319,934 )
2002	2002	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Genetics and Developmental Biology Research and Research Training	000	13	2/25/2002	NON-COMPETING CONTINUATION	$319,934
														Subtotal = $319,934

Issue Date FY: 2001 ( Subtotal = $310,709 )
2001	2001	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Genetics and Developmental Biology Research and Research Training	000	12	3/2/2001	NON-COMPETING CONTINUATION	$310,709
														Subtotal = $310,709

Issue Date FY: 2000 ( Subtotal = $309,252 )
2000	2000	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Genetics and Developmental Biology Research and Research Training	000	11	2/24/2000	NON-COMPETING CONTINUATION	$309,252
														Subtotal = $309,252

Issue Date FY: 1999 ( Subtotal = $296,609 )
1999	1999	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Genetics and Developmental Biology Research and Research Training	000	10	2/25/1999	COMPETING CONTINUATION	$296,609
														Subtotal = $296,609

Grand Total All Awards = $4,426,940

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INTERACTIONS BETWEEN AGROBACTERIUM AND HOST PLANTS

Award Number: R01GM042893

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/1989

PERIOD OF PERFORMANCE END DATE: 06/30/2012

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