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The role of plasticity in loss of vision caused by retinitis pigmentosa

Award Number: R01EY035885
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2025
PERIOD OF PERFORMANCE END DATE: 12/31/2028

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The role of plasticity in loss of vision caused by retinitis pigmentosa - Abstract Retinitis pigmentosa (RP) is the most common group of inherited retinal disorders associated with progressive loss of vision. RP is typically diagnosed in adulthood following the onset of night blindness and impaired peripheral vision. Longitudinal studies of patients with RP reveal that their loss of visual acuity is significantly slower than the deterioration of their photoreceptor function. How the visual system sustains acuity despite the progressive loss of photoreceptors is unclear. Our hypothesis is that flexibility within the circuits of the visual system engage with the progressive loss of visual output to impair acuity. We will test our hypothesis by first characterizing the deficit in acuity and related functional characteristics in visual cortex and retina in using the rhodopsin P23H/+ (rho P23H/+) mutant mouse model. These mice have similar declines in retinal function and are a good model of human RP. Then we will evaluate whether enhancing or reducing experience-dependent plasticity affects the trajectory of the progressive loss of vision of rho P23H/+ mice by then characterizing the deficit in acuity and related functional characteristics in visual cortex and retina in using the rhodopsin P23H/+ (rho P23H/+) mutant mice that also lack a gene that limits plasticity in adult visual circuitry (nogo-66 receptor, ngr1) or that is required for visual plasticity (activity-regulated cytoskeleton-associated protein, ARC). Mice lacking ngr1 (ngr1 -/-) display greater visual plasticity than adult wild-type mice while mice lacking ARC (ARC -/-) exhibit reduced visual plasticity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $304,804 )
2025	2025	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Vision Research	000	2	6/5/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$304,804
														Subtotal = $304,804

Issue Date FY: 2024 ( Subtotal = $463,927 )
2024	2024	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Vision Research	000	1	12/12/2023	NEW	$463,927
														Subtotal = $463,927

Grand Total All Awards = $768,731

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The role of plasticity in loss of vision caused by retinitis pigmentosa

Award Number: R01EY035885

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2025

PERIOD OF PERFORMANCE END DATE: 12/31/2028

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