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Cortical basis of binocular depth perception

Award Number: R01EY034092
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2024
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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Cortical basis of binocular depth perception - Abstract The functional properties of the visual system are most sensitive to disruptions of normal vision during developmental ‘critical periods’. Interestingly, the critical periods for several functional properties, such as ocular dominance and acuity, overlap during development. Abnormal vision during these overlapping critical periods, because of cataracts or misalignment of the two eyes for example, is the cause of amblyopia. Amblyopia is a prevalent visual disorder in children and can present with any of several visual problems including lower visual acuity and impaired depth perception. Yet, how depth perception is affected by abnormal vision has remained elusive. In the proposed research, we investigate the circuit basis for the development and plasticity of depth perception in the mouse. The development of stereoscopic vision is much slower than other characteristics of vision and relies on complex properties of binocular disparity. Disparity between the eyes is what produces the perception of depth. We will characterize multiple dimensions of its development and plasticity by taking advantage of a natural depth discrimination task that depends on binocular vision. Over this same period, we will measure with two-photon microscopy how complex disparity properties are refined in the visual cortex and area LM (a secondary binocular visual area), as well as how and when they are sensitive to abnormal vision. Understanding the properties of binocular depth perception and the development of those properties will provide a foundation for developing therapeutic approaches to treat developmental visual disorders such as amblyopia that cause stereovision deficits.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $381,913 )
2026	2026	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Vision Research	000	5	8/21/2026	NON-COMPETING CONTINUATION	$381,913
														Subtotal = $381,913

Issue Date FY: 2025 ( Subtotal = $324,777 )
2025	2025	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Vision Research	003	4	9/19/2025	NON-COMPETING CONTINUATION	$324,777
2025	2024	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Vision Research	000	2	5/15/2025	NON-COMPETING CONTINUATION	-$64,560
2025	2024	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Vision Research	002	2	6/11/2025	NON-COMPETING CONTINUATION	$0
2025	2024	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Vision Research	001	3	5/15/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$64,560
														Subtotal = $324,777

Issue Date FY: 2024 ( Subtotal = $384,631 )
2024	2024	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Vision Research	000	2	7/1/2024	NON-COMPETING CONTINUATION	$384,631
														Subtotal = $384,631

Issue Date FY: 2023 ( Subtotal = $398,884 )
2023	2023	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Vision Research	000	1	6/13/2023	NEW	$398,884
														Subtotal = $398,884

Grand Total All Awards = $1,490,205

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Cortical basis of binocular depth perception

Award Number: R01EY034092

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2024

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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