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Behavioral Consequences and cellular substrates of plasticity in visual cortex

Award Number: R01EY023037
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2013
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Behavioral Consequences and cellular substrates of plasticity in visual cortex - Detection of novel stimuli that may predict reward or punishment requires long-term memory for, and recognition of, stimuli that are familiar. Novelty detection and familiarity recognition are often impaired in neuropsychiatric disease, so understanding the neurobiological underpinnings is an important goal. We recently discovered that memory of visual stimulus familiarity is stored via synaptic modifications in primary visual cortex of mice. The primary aims of our research are now to (a) identify how information is stored by the collective activity of neurons in primary visual cortex and the reciprocally connected thalamus, (b) pinpoint the key sites in the cortical microcircuit where the essential synaptic modifications occur, and (c) determine how these modifications are expressed at the level of circuits and behavior. Beyond the relevance of our proposed research to identifying the mechanisms underlying visual recognition memory, they will broaden our understanding of how primary sensory areas are modified by sensory experience in order to modify behavior, which remains one of the great challenges in basic neuroscience.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $613,675 )
2025	2025	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	000	12	4/21/2025	NON-COMPETING CONTINUATION	$613,675
														Subtotal = $613,675

Issue Date FY: 2024 ( Subtotal = $613,675 )
2024	2024	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	000	11	4/18/2024	NON-COMPETING CONTINUATION	$613,675
														Subtotal = $613,675

Issue Date FY: 2023 ( Subtotal = $613,675 )
2023	2023	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	002	10	4/21/2023	NON-COMPETING CONTINUATION	$613,675
2023	2022	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	001	9	11/7/2022	COMPETING CONTINUATION	$124
2023	2020	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	000	8	11/7/2022	NON-COMPETING CONTINUATION	-$124
														Subtotal = $613,675

Issue Date FY: 2022 ( Subtotal = $606,695 )
2022	2022	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	001	9	4/22/2022	COMPETING CONTINUATION	$606,695
2022	2020	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	002	8	6/16/2022	NON-COMPETING CONTINUATION	$124
2022	2020	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	000	8	3/4/2022	NON-COMPETING CONTINUATION	-$124
														Subtotal = $606,695

Issue Date FY: 2020 ( Subtotal = $486,777 )
2020	2020	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	000	8	7/23/2020	NON-COMPETING CONTINUATION	$486,777
														Subtotal = $486,777

Issue Date FY: 2019 ( Subtotal = $486,777 )
2019	2019	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	000	7	8/20/2019	NON-COMPETING CONTINUATION	$486,777
														Subtotal = $486,777

Issue Date FY: 2018 ( Subtotal = $589,427 )
2018	2018	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	004	6	7/13/2018	NON-COMPETING CONTINUATION	$486,777
2018	2018	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	000	5	2/9/2018	SUPPLEMENT FOR EXPANSION	$102,650
2018	2017	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	003	5	5/2/2018	COMPETING CONTINUATION	$2,058
2018	2016	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	001	4	2/12/2018	EXTENSION WITH OR WITHOUT FUNDS	$0
2018	2016	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	002	4	5/2/2018	EXTENSION WITH OR WITHOUT FUNDS	-$2,058
														Subtotal = $589,427

Issue Date FY: 2017 ( Subtotal = $485,146 )
2017	2017	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	001	5	9/6/2017	COMPETING CONTINUATION	$485,146
2017	2015	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	000	3	2/6/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $485,146

Issue Date FY: 2016 ( Subtotal = $390,000 )
2016	2016	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	000	4	8/11/2016	EXTENSION WITH OR WITHOUT FUNDS	$390,000
														Subtotal = $390,000

Issue Date FY: 2015 ( Subtotal = $382,200 )
2015	2015	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	000	3	7/15/2015	NON-COMPETING CONTINUATION	$382,200
														Subtotal = $382,200

Issue Date FY: 2014 ( Subtotal = $382,200 )
2014	2014	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	000	2	7/28/2014	NON-COMPETING CONTINUATION	$382,200
														Subtotal = $382,200

Issue Date FY: 2013 ( Subtotal = $390,000 )
2013	2013	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	000	1	7/25/2013	NEW	$390,000
														Subtotal = $390,000

Grand Total All Awards = $6,040,247

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Behavioral Consequences and cellular substrates of plasticity in visual cortex

Award Number: R01EY023037

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2013

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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