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Circuit specializations of developing visual networks

Award Number: R01EY022730
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2013
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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Circuit specializations of developing visual networks - The visual pathways of the human fetal brain are highly active before birth. During this pre-visual period spontaneous activity in the retina provides the primary input to visual brain and data from neonatal rodents implicate this early activity in normal development and organization of visual pathways. While we understand much about the specialized circuits that produce activity in the developing retina, and the consequences of disruption of that activity for eye and brain outcomes, we know little of the brain activity that supports the earliest stages of sensory development. Early retinal activity is not passively transmitted in the developing brain. Rather, it is actively amplified and transformed by mechanisms unique to this developmental stage. This proposal will use a rodent model of human fetal brain development to follow the propagation and transformation of early retinal activity at each stage of the primary visual pathway in thalamus and visual cortex, to understand the mechanisms of its transformation, the role of individual thalamic regions, and the ultimate impact of this circuit on functional visual maps and responsiveness. This knowledge is important because disruption of early retinal, thalamic, or cortical activity associated with preterm birth or hypoxic birth complications can cause lasting visual impairment. Any treatment or early diagnosis (such as using EEG) requires knowledge of the normal developmental circuitry, activity and function of thalamus and cortex, which this project will provide.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $588,600 )
2026	2026	GEORGE WASHINGTON UNIVERSITY (THE)	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Vision Research	000	13	8/25/2026	NON-COMPETING CONTINUATION	$588,600
														Subtotal = $588,600

Issue Date FY: 2025 ( Subtotal = $500,310 )
2025	2025	GEORGE WASHINGTON UNIVERSITY (THE)	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Vision Research	001	12	9/19/2025	NON-COMPETING CONTINUATION	$500,310
2025	2022	GEORGE WASHINGTON UNIVERSITY (THE)	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Vision Research	000	10	12/18/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $500,310

Issue Date FY: 2024 ( Subtotal = $588,600 )
2024	2024	GEORGE WASHINGTON UNIVERSITY (THE)	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Vision Research	000	11	8/12/2024	COMPETING CONTINUATION	$588,600
														Subtotal = $588,600

Issue Date FY: 2022 ( Subtotal = $495,798 )
2022	2022	GEORGE WASHINGTON UNIVERSITY, THE	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Vision Research	000	10	8/12/2022	NON-COMPETING CONTINUATION	$495,798
														Subtotal = $495,798

Issue Date FY: 2021 ( Subtotal = $495,797 )
2021	2021	GEORGE WASHINGTON UNIVERSITY, THE	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Vision Research	000	9	8/31/2021	NON-COMPETING CONTINUATION	$495,797
														Subtotal = $495,797

Issue Date FY: 2020 ( Subtotal = $511,132 )
2020	2020	THE GEORGE WASHINGTON UNIVERSITY	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Vision Research	000	8	8/6/2020	NON-COMPETING CONTINUATION	$511,132
														Subtotal = $511,132

Issue Date FY: 2019 ( Subtotal = $511,132 )
2019	2019	GEORGE WASHINGTON UNIVERSITY, THE	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Vision Research	002	7	8/27/2019	NON-COMPETING CONTINUATION	$511,132
2019	2018	GEORGE WASHINGTON UNIVERSITY, THE	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Vision Research	001	6	2/17/2019	COMPETING CONTINUATION	$5,919
2019	2017	GEORGE WASHINGTON UNIVERSITY, THE	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Vision Research	000	5	2/17/2019	NON-COMPETING CONTINUATION	-$5,919
														Subtotal = $511,132

Issue Date FY: 2018 ( Subtotal = $487,207 )
2018	2018	THE GEORGE WASHINGTON UNIVERSITY	2121 I ST NW STE 601	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Vision Research	000	6	8/16/2018	COMPETING CONTINUATION	$487,207
														Subtotal = $487,207

Issue Date FY: 2017 ( Subtotal = $396,250 )
2017	2017	THE GEORGE WASHINGTON UNIVERSITY	2121 I ST NW STE 601	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Vision Research	002	5	8/14/2017	NON-COMPETING CONTINUATION	$396,250
2017	2016	THE GEORGE WASHINGTON UNIVERSITY	2121 I ST NW STE 601	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Vision Research	001	4	1/30/2017	EXTENSION WITH OR WITHOUT FUNDS	$51,416
2017	2015	THE GEORGE WASHINGTON UNIVERSITY	2121 I ST NW STE 601	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Vision Research	000	3	1/30/2017	NON-COMPETING CONTINUATION	-$51,416
														Subtotal = $396,250

Issue Date FY: 2016 ( Subtotal = $396,250 )
2016	2016	GEORGE WASHINGTON UNIVERSITY	44983 KNOLL SQUARE	ASHBURN	VA	20147	LOUDOUN	USA	Vision Research	000	4	8/10/2016	EXTENSION WITH OR WITHOUT FUNDS	$396,250
														Subtotal = $396,250

Issue Date FY: 2015 ( Subtotal = $388,325 )
2015	2015	GEORGE WASHINGTON UNIVERSITY	44983 KNOLL SQUARE	ASHBURN	VA	20147	LOUDOUN	USA	Vision Research	000	3	8/19/2015	NON-COMPETING CONTINUATION	$388,325
														Subtotal = $388,325

Issue Date FY: 2014 ( Subtotal = $388,325 )
2014	2014	GEORGE WASHINGTON UNIVERSITY	44983 KNOLL SQUARE	ASHBURN	VA	20147	LOUDOUN	USA	Vision Research	000	2	8/26/2014	NON-COMPETING CONTINUATION	$388,325
														Subtotal = $388,325

Issue Date FY: 2013 ( Subtotal = $388,645 )
2013	2013	GEORGE WASHINGTON UNIVERSITY	44983 KNOLL SQUARE	ASHBURN	VA	20147	LOUDOUN	USA	Vision Research	000	1	8/23/2013	NEW	$388,645
														Subtotal = $388,645

Grand Total All Awards = $6,136,371

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Circuit specializations of developing visual networks

Award Number: R01EY022730

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2013

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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