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Use of Correlated Data Methods in Ophthalmology

Award Number: R01EY022445
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2013
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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Use of Correlated Data Methods in Ophthalmology - Project Summary / Abstract Some exposures in ophthalmology may not have an immediate effect, but instead a lag is necessary. For example, there is a literature on possible cataractogenic effects of corticosteroid eyedrops (CS) among uveitis patients. However, the precise impact of dose and/or duration of use are unknown. Also, the lag between CS administration and development of cataract is unknown. Another possible application is to study the effects of dietary and/or supplement use on development of AMD, where a lag effect is also likely to occur. The goal of specific aim 1 is to use latency analysis methods for ophthalmological endpoints. Latency methods have been used in pharmacoepidemiology, but to our knowledge, have never been used for ophthalmologic endpoints. The AREDS study was a landmark study in the epidemiology of AMD. A byproduct of this study was the development of the AREDS severity scale which is an ordinal scale ranging from 1 for no AMD to 9+ for advanced AMD (AAMD). The usual analysis for risk factors is a time-to-event analysis based on the Cox Proportional Hazards Model, where the event is reaching grade 9+. This is a valid, but inefficient analysis. There are many eyes (about 40%) which show changes (either an increase or decrease), but which don't develop AAMD. There are risk factors which are associated with these changes, but all such changes are treated as censored data and are considered “non-events”. In Aim 2, we propose to use an ordinal regression model for changes between successive visits which would provide a more efficient use of the data. There have been previous multi-state ordinal models proposed, but separate models are fit for each possible transition and are not integrated into an overall assessment of risk for specific covariates. This has application not only for AMD, but also for other ordinal scales used for other ophthalmologic conditions, such as diabetic retinopathy. For Aim 3, we propose to continue our work on applying correlated data methods to risk prediction for endpoints such as AUC. We will specifically compare methods for estimating AUC for small samples, extensive numbers of tied prediction scores and presence of both bilateral and unilateral subjects. In addition, we will incorporate clustered data methods for estimation of NRI, which to our knowledge, has never been done before. In Aim 4, we will continue our work on translation of clustered data methods for the eye research community including (a) correlated data methods in survival analysis, (b) analysis of longitudinal binary ocular data, and (c) sample size/power calculations based on the eye as the unit of analysis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	000	10	10/30/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $360,900 )
2025	2025	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	000	10	1/13/2025	NON-COMPETING CONTINUATION	$487,751
2025	2020	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	001	6	3/28/2025	NON-COMPETING CONTINUATION	-$126,851
														Subtotal = $360,900

Issue Date FY: 2024 ( Subtotal = $487,751 )
2024	2024	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	000	9	1/9/2024	NON-COMPETING CONTINUATION	$487,751
														Subtotal = $487,751

Issue Date FY: 2023 ( Subtotal = $484,401 )
2023	2023	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	000	8	2/6/2023	NON-COMPETING CONTINUATION	$484,401
														Subtotal = $484,401

Issue Date FY: 2022 ( Subtotal = $546,741 )
2022	2022	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	001	7	12/17/2021	COMPETING CONTINUATION	$546,741
2022	2022	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	003	7	7/12/2022	COMPETING CONTINUATION	$126,851
2022	2020	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	000	6	12/9/2021	NON-COMPETING CONTINUATION	$0
2022	2020	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	002	6	7/12/2022	NON-COMPETING CONTINUATION	-$126,851
														Subtotal = $546,741

Issue Date FY: 2020 ( Subtotal = $451,134 )
2020	2020	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	000	6	4/1/2020	NON-COMPETING CONTINUATION	$451,134
														Subtotal = $451,134

Issue Date FY: 2019 ( Subtotal = $451,134 )
2019	2019	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	000	5	5/13/2019	NON-COMPETING CONTINUATION	$451,134
														Subtotal = $451,134

Issue Date FY: 2018 ( Subtotal = $513,424 )
2018	2018	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	001	4	3/28/2018	COMPETING CONTINUATION	$513,424
2018	2018	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	003	4	5/2/2018	COMPETING CONTINUATION	$20
2018	2015	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	002	3	5/2/2018	NON-COMPETING CONTINUATION	$1,671
2018	2015	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	000	3	2/26/2018	NON-COMPETING CONTINUATION	-$1,691
														Subtotal = $513,424

Issue Date FY: 2015 ( Subtotal = $375,392 )
2015	2015	BRIGHAM & WOMEN`S HOSPITAL	10 VINING STREET	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	000	3	8/28/2015	NON-COMPETING CONTINUATION	$375,392
														Subtotal = $375,392

Issue Date FY: 2014 ( Subtotal = $376,010 )
2014	2014	BRIGHAM & WOMEN`S HOSPITAL	10 VINING STREET	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	000	2	9/12/2014	NON-COMPETING CONTINUATION	$376,010
														Subtotal = $376,010

Issue Date FY: 2013 ( Subtotal = $423,534 )
2013	2013	BRIGHAM & WOMEN`S HOSPITAL	10 VINING STREET	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	000	1	8/29/2013	NEW	$423,534
														Subtotal = $423,534

Grand Total All Awards = $4,470,421

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Use of Correlated Data Methods in Ophthalmology

Award Number: R01EY022445

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2013

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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