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Imaging Structure and Function of Photoreceptors

Award Number: R01EY018339
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2007
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Imaging Structure and Function of Photoreceptors - Project Summary/Abstract Human vision starts when photoreceptors collect and respond to light. Normal photoreceptor function is essential for normal vision, yet techniques to assess these processes in vivo are limited. New optical modalities that are rapid, specific, and non‐invasive promise to greatly expand our capability to monitor more accurately and completely photoreceptors. This study takes advantage of unique adaptive‐optics OCT instrumentation developed in my laboratory in conjunction with custom algorithms for sub‐cellular image registration and phase‐sensitive detection to measure anatomical and physiological properties of individual photoreceptors. We will use this technique to investigate three specific aims that quantify the spectral sensitivity profiles of photoreceptors, the expression of photoreceptor spectral types in color vision deficiencies, and the temporal dynamics of photoreceptor loss in retinitis pigmentosa patients. The long term goal of this research is to establish high resolution, high specificity optical techniques as valid tools for probing structure and physiologic processes of the retina at the cellular scale. The resulting ability to study cells in vivo will improve early detection of and treatment monitoring for diseases that impact the retina.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $549,219 )
2025	2025	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	18	6/2/2025	NON-COMPETING CONTINUATION	$549,219
														Subtotal = $549,219

Issue Date FY: 2024 ( Subtotal = $557,219 )
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	17	4/29/2024	NON-COMPETING CONTINUATION	$557,219
														Subtotal = $557,219

Issue Date FY: 2023 ( Subtotal = $560,266 )
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	002	16	6/7/2023	NON-COMPETING CONTINUATION	$560,266
2023	2022	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	001	15	5/31/2023	COMPETING CONTINUATION	$7
2023	2020	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	14	5/31/2023	NON-COMPETING CONTINUATION	-$7
														Subtotal = $560,266

Issue Date FY: 2022 ( Subtotal = $577,031 )
2022	2022	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	15	8/12/2022	COMPETING CONTINUATION	$577,031
														Subtotal = $577,031

Issue Date FY: 2020 ( Subtotal = $455,897 )
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVENUE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	14	7/17/2020	NON-COMPETING CONTINUATION	$455,897
														Subtotal = $455,897

Issue Date FY: 2019 ( Subtotal = $456,097 )
2019	2019	TRUSTEES OF INDIANA UNIVERSITY	BRYAN HALL 107 S INDIANA AVENUE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	13	7/17/2019	NON-COMPETING CONTINUATION	$456,097
														Subtotal = $456,097

Issue Date FY: 2018 ( Subtotal = $463,410 )
2018	2018	TRUSTEES OF INDIANA UNIVERSITY	BRYAN HALL 107 S INDIANA AVENUE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	12	7/9/2018	NON-COMPETING CONTINUATION	$463,410
														Subtotal = $463,410

Issue Date FY: 2017 ( Subtotal = $461,610 )
2017	2017	TRUSTEES OF INDIANA UNIVERSITY	BRYAN HALL 107 S INDIANA AVENUE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	002	11	7/27/2017	NON-COMPETING CONTINUATION	$461,610
2017	2016	TRUSTEES OF INDIANA UNIVERSITY	BRYAN HALL 107 S INDIANA AVENUE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	001	10	1/31/2017	COMPETING CONTINUATION	$51,445
2017	2015	TRUSTEES OF INDIANA UNIVERSITY	BRYAN HALL 107 S INDIANA AVENUE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	9	1/31/2017	NON-COMPETING CONTINUATION	-$51,445
														Subtotal = $461,610

Issue Date FY: 2016 ( Subtotal = $468,691 )
2016	2016	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	10	8/24/2016	COMPETING CONTINUATION	$468,691
														Subtotal = $468,691

Issue Date FY: 2015 ( Subtotal = $371,224 )
2015	2015	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	9	8/27/2015	NON-COMPETING CONTINUATION	$371,224
														Subtotal = $371,224

Issue Date FY: 2014 ( Subtotal = $369,577 )
2014	2014	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	8	8/12/2014	NON-COMPETING CONTINUATION	$369,577
														Subtotal = $369,577

Issue Date FY: 2013 ( Subtotal = $354,540 )
2013	2013	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	7	8/7/2013	NON-COMPETING CONTINUATION	$354,540
														Subtotal = $354,540

Issue Date FY: 2012 ( Subtotal = $372,640 )
2012	2012	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	001	6	8/6/2012	COMPETING CONTINUATION	$372,640
2012	2011	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	5	8/6/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $372,640

Issue Date FY: 2011 ( Subtotal = $323,968 )
2011	2011	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	5	8/17/2011	NON-COMPETING CONTINUATION	$323,968
														Subtotal = $323,968

Issue Date FY: 2010 ( Subtotal = $334,407 )
2010	2010	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	4	8/11/2010	NON-COMPETING CONTINUATION	$334,407
														Subtotal = $334,407

Issue Date FY: 2009 ( Subtotal = $338,300 )
2009	2009	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	3	8/20/2009	NON-COMPETING CONTINUATION	$338,300
														Subtotal = $338,300

Issue Date FY: 2008 ( Subtotal = $329,011 )
2008	2008	INDIANA UNIVERSITY, BLOOMINGTON	BRYAN 215C	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	2	8/22/2008	NON-COMPETING CONTINUATION	$329,011
														Subtotal = $329,011

Issue Date FY: 2007 ( Subtotal = $333,150 )
2007	2007	INDIANA UNIVERSITY, BLOOMINGTON	BRYAN 215C	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	1	8/20/2007	NEW	$333,150
														Subtotal = $333,150

Grand Total All Awards = $7,676,257

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Imaging Structure and Function of Photoreceptors

Award Number: R01EY018339

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2007

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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