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Accommodation and Defocus in the Infant Visual System

Award Number: R01EY014460
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Accommodation and Defocus in the Infant Visual System - Project Summary/Abstract: Postnatal development of the human visual system is dependent on visual experience. Abnormal visual experience during infancy and childhood can lead to strabismic misalignment of the eyes and amblyopia. The goal of the proposed research is to understand how the visual system uses its available natural experience to coordinate eye alignment and focus during infancy and early childhood, in the context of prevention of these clinical conditions. There are two interrelated projects: i) To understand how depth information across the visual field can be used to coordinate eye alignment and focus during early postnatal development, and how common clinical disorders during early childhood can disrupt that coordination. ii) To understand which image structure across the visual field is capable of driving a conjugate orienting eye movement during early postnatal development, and how the binocular aspects of that movement can be disrupted by common clinical disorders. These projects will test hypotheses and build models to determine the amounts of conditions such as anisometropia that can disrupt ocular motor control as a function of human postnatal age. Previous studies of the development of focusing accommodation responses and aligning vergence responses have concentrated on 2D stimuli in the central visual field, while the brain needs to function in the full field, dynamic, three-dimensional natural environment in order for a patient to develop typical vision. It is the interaction between this visual environment and the quality of retinal visual experience that motor control can provide that defines a patient’s experience-dependent development. The results will provide i) evidence-based clinical guidelines for the prevention of amblyopia and strabismus ii) constraints for biologically-inspired simulations of the development of vision.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $396,250 )
2025	2025	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	22	4/7/2025	NON-COMPETING CONTINUATION	$396,250
														Subtotal = $396,250

Issue Date FY: 2024 ( Subtotal = $396,250 )
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	21	4/15/2024	NON-COMPETING CONTINUATION	$396,250
														Subtotal = $396,250

Issue Date FY: 2023 ( Subtotal = $396,250 )
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	002	20	8/14/2023	NON-COMPETING CONTINUATION	$396,250
2023	2022	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	001	19	5/16/2023	COMPETING CONTINUATION	$22,979
2023	2021	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	18	5/16/2023	NON-COMPETING CONTINUATION	-$22,979
														Subtotal = $396,250

Issue Date FY: 2022 ( Subtotal = $396,250 )
2022	2022	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	001	19	8/11/2022	COMPETING CONTINUATION	$396,250
2022	2021	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	18	8/5/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $396,250

Issue Date FY: 2021 ( Subtotal = $382,337 )
2021	2021	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	18	6/18/2021	NON-COMPETING CONTINUATION	$382,337
														Subtotal = $382,337

Issue Date FY: 2020 ( Subtotal = $394,157 )
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVENUE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	17	5/13/2020	NON-COMPETING CONTINUATION	$394,157
														Subtotal = $394,157

Issue Date FY: 2019 ( Subtotal = $394,148 )
2019	2019	TRUSTEES OF INDIANA UNIVERSITY	BRYAN HALL 107 S INDIANA AVENUE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	16	6/4/2019	NON-COMPETING CONTINUATION	$394,148
														Subtotal = $394,148

Issue Date FY: 2018 ( Subtotal = $394,387 )
2018	2018	TRUSTEES OF INDIANA UNIVERSITY	BRYAN HALL 107 S INDIANA AVENUE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	15	6/7/2018	NON-COMPETING CONTINUATION	$394,387
														Subtotal = $394,387

Issue Date FY: 2017 ( Subtotal = $368,596 )
2017	2017	TRUSTEES OF INDIANA UNIVERSITY	BRYAN HALL 107 S INDIANA AVENUE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	002	14	9/5/2017	COMPETING CONTINUATION	$97,087
2017	2017	TRUSTEES OF INDIANA UNIVERSITY	205C BRYAN HALL, 105 N INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	14	5/25/2017	COMPETING CONTINUATION	$368,596
2017	2016	TRUSTEES OF INDIANA UNIVERSITY	BRYAN HALL 107 S INDIANA AVENUE	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	001	13	9/5/2017	EXTENSION WITH OR WITHOUT FUNDS	-$97,087
														Subtotal = $368,596

Issue Date FY: 2016 ( Subtotal = $351,152 )
2016	2016	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	13	4/20/2016	EXTENSION WITH OR WITHOUT FUNDS	$351,152
														Subtotal = $351,152

Issue Date FY: 2015 ( Subtotal = $316,299 )
2015	2015	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	12	4/23/2015	NON-COMPETING CONTINUATION	$316,299
														Subtotal = $316,299

Issue Date FY: 2014 ( Subtotal = $353,787 )
2014	2014	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	11	5/12/2014	NON-COMPETING CONTINUATION	$353,787
														Subtotal = $353,787

Issue Date FY: 2013 ( Subtotal = $365,120 )
2013	2013	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	001	10	4/11/2013	COMPETING CONTINUATION	$365,120
2013	2012	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	9	4/9/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $365,120

Issue Date FY: 2012 ( Subtotal = $358,776 )
2012	2012	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	9	3/1/2012	NON-COMPETING CONTINUATION	$358,776
														Subtotal = $358,776

Issue Date FY: 2011 ( Subtotal = $358,776 )
2011	2011	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	001	8	6/6/2011	NON-COMPETING CONTINUATION	$22,423
2011	2011	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	8	2/10/2011	NON-COMPETING CONTINUATION	$336,353
														Subtotal = $358,776

Issue Date FY: 2010 ( Subtotal = $336,353 )
2010	2010	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	7	3/12/2010	NON-COMPETING CONTINUATION	$336,353
														Subtotal = $336,353

Issue Date FY: 2009 ( Subtotal = $339,750 )
2009	2009	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	001	6	4/20/2009	NON-COMPETING CONTINUATION	$33,975
2009	2009	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	6	2/9/2009	NON-COMPETING CONTINUATION	$305,775
														Subtotal = $339,750

Issue Date FY: 2008 ( Subtotal = $340,125 )
2008	2008	INDIANA UNIVERSITY, BLOOMINGTON	BRYAN 215C	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	5	3/3/2008	COMPETING CONTINUATION	$340,125
														Subtotal = $340,125

Issue Date FY: 2006 ( Subtotal = $211,142 )
2006	2006	INDIANA UNIVERSITY, BLOOMINGTON	BRYAN 215C	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	4	5/29/2006	NON-COMPETING CONTINUATION	$211,142
														Subtotal = $211,142

Issue Date FY: 2005 ( Subtotal = $216,677 )
2005	2005	INDIANA UNIVERSITY, BLOOMINGTON	BRYAN 215C	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	3	6/10/2005	NON-COMPETING CONTINUATION	$216,677
														Subtotal = $216,677

Issue Date FY: 2004 ( Subtotal = $217,109 )
2004	2004	INDIANA UNIVERSITY, BLOOMINGTON	BRYAN 215C	BLOOMINGTON	IN	47405	MONROE	USA	Vision Research	000	2	6/21/2004	NON-COMPETING CONTINUATION	$217,109
														Subtotal = $217,109

Grand Total All Awards = $7,493,637

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Accommodation and Defocus in the Infant Visual System

Award Number: R01EY014460

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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