Thursday, April 25, 2024 4/25/2024

Cataractogenesis, Connexin Mutants and Genetic Modifier(s)

Award Number: R01EY013849
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

Project Summary Genetic variances, environmental stress factors and aging can initiate pathological conditions in lens cells leading to different types of cataracts. Previous studies show that the postnatal onset and severity of lens nuclear cataracts are impacted by a functional loss of connexin 46 (Cx46) with genetic variances including CP49 and periaxin (Prx) occurred between mouse strains C57BL/6J (B6) and 129 Svjae (129). This research proposal will evaluate novel hypotheses about how intercellular gap junctions consisting of Cx46 and Prx mediated membrane/cytoskeletal complexes coordinately regulate interior lens fiber cell morphogenesis and calcium homeostasis needed for lens transparency. This project will provide a comprehensive mechanistic understanding about how calcium influx and efflux as well as interlocking structures of lens fibers are regulated and maintained by the adhesion and transport mosaic systems including gap junctions, Aqp0, calcium channels linked to cytoskeletons through scaffold proteins such as Prx. Completion of this research project will also provide essential knowledge about genetic variations among common mouse strains such as C57BL/6J and 129 to the lens research community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $361,125 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	000	21	4/10/2024	NON-COMPETING CONTINUATION	$361,125
														Subtotal = $361,125

Issue Date FY: 2023 ( Subtotal = $361,125 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	000	20	5/15/2023	NON-COMPETING CONTINUATION	$361,125
														Subtotal = $361,125

Issue Date FY: 2022 ( Subtotal = $350,291 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	002	19	6/21/2022	NON-COMPETING CONTINUATION	$350,291
2022	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	001	18	10/13/2021	COMPETING CONTINUATION	$142,212
2022	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	000	17	10/13/2021	NON-COMPETING CONTINUATION	-$142,212
														Subtotal = $350,291

Issue Date FY: 2021 ( Subtotal = $360,563 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	000	18	4/26/2021	COMPETING CONTINUATION	$360,563
														Subtotal = $360,563

Issue Date FY: 2019 ( Subtotal = $392,500 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	000	17	4/17/2019	NON-COMPETING CONTINUATION	$392,500
														Subtotal = $392,500

Issue Date FY: 2018 ( Subtotal = $392,500 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	16	4/9/2018	NON-COMPETING CONTINUATION	$392,500
														Subtotal = $392,500

Issue Date FY: 2017 ( Subtotal = $392,500 )
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	15	5/1/2017	NON-COMPETING CONTINUATION	$353,250
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	001	15	7/10/2017	NON-COMPETING CONTINUATION	$39,250
														Subtotal = $392,500

Issue Date FY: 2016 ( Subtotal = $392,500 )
2016	2016	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	14	4/18/2016	COMPETING CONTINUATION	$392,500
														Subtotal = $392,500

Issue Date FY: 2015 ( Subtotal = $376,075 )
2015	2015	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	13	3/13/2015	NON-COMPETING CONTINUATION	$376,075
														Subtotal = $376,075

Issue Date FY: 2014 ( Subtotal = $376,075 )
2014	2014	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	12	3/7/2014	NON-COMPETING CONTINUATION	$376,075
														Subtotal = $376,075

Issue Date FY: 2013 ( Subtotal = $364,563 )
2013	2013	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	11	4/24/2013	NON-COMPETING CONTINUATION	$345,375
2013	2013	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	001	11	6/6/2013	NON-COMPETING CONTINUATION	$19,188
														Subtotal = $364,563

Issue Date FY: 2012 ( Subtotal = $383,750 )
2012	2012	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	001	10	3/26/2012	COMPETING CONTINUATION	$383,750
2012	2011	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	9	3/22/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $383,750

Issue Date FY: 2011 ( Subtotal = $361,152 )
2011	2011	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	9	1/14/2011	NON-COMPETING CONTINUATION	$338,580
2011	2011	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	001	9	6/14/2011	NON-COMPETING CONTINUATION	$22,572
														Subtotal = $361,152

Issue Date FY: 2010 ( Subtotal = $376,200 )
2010	2010	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	8	1/14/2010	NON-COMPETING CONTINUATION	$376,200
														Subtotal = $376,200

Issue Date FY: 2009 ( Subtotal = $690,000 )
2009	2009	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	7	1/27/2009	NON-COMPETING CONTINUATION	$342,000
2009	2009	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	001	7	4/29/2009	NON-COMPETING CONTINUATION	$38,000
2009	2009	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	002	7	9/11/2009	SUPPLEMENT FOR EXPANSION	$310,000
														Subtotal = $690,000

Issue Date FY: 2008 ( Subtotal = $372,400 )
2008	2008	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	6	3/4/2008	NON-COMPETING CONTINUATION	$372,400
														Subtotal = $372,400

Issue Date FY: 2007 ( Subtotal = $380,000 )
2007	2007	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	5	1/26/2007	COMPETING CONTINUATION	$380,000
														Subtotal = $380,000

Issue Date FY: 2004 ( Subtotal = $319,120 )
2004	2004	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	4	1/12/2004	NON-COMPETING CONTINUATION	$319,120
														Subtotal = $319,120

Issue Date FY: 2003 ( Subtotal = $379,212 )
2003	2003	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	3		CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$266,931
2003	2003	SCRIPPS RESEARCH INSTITUTE, TPC 7	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Vision Research	000	2		NON-COMPETING CONTINUATION	$112,281
														Subtotal = $379,212

Issue Date FY: 2002 ( Subtotal = $400,512 )
2002	2002	SCRIPPS RESEARCH INSTITUTE, TPC 7	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Vision Research	000	1	1/21/2002	NEW	$400,512
														Subtotal = $400,512

Grand Total All Awards = $7,782,163

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Cataractogenesis, Connexin Mutants and Genetic Modifier(s)

Award Number: R01EY013849

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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