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Biomechanical Analysis in Strabismus Surgery

Award Number: R01EY008313
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/06/1991
PERIOD OF PERFORMANCE END DATE: 05/31/2029

Group Awards By:

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Biomechanical Analysis in Strabismus Surgery - We propose 3 interrelated aims to define the biomechanics of the extraocular (eye rotating) muscles and optic nerve in health and visual disease, understand novel extraocular muscle actions that maintain binocular alignment, and characterize mechanical effects that may contribute to glaucoma and severe myopia (nearsightedness). We aim to improve treatment of strabismus, misalignment of visual directions of the eyes, as well as glaucoma, a common blinding optic nerve disease; and gain insight into the cause of high axial myopia, an eye elongation and shape distortion that has become a worldwide epidemic and major cause of blindness. These conditions may all be related to the actions of the extraocular muscles (EOMs). We propose the dynamic, repetitive strain due to eye movement is a common factor in several visual disorders. Aim I will clarify superior oblique (SO) palsy, a common cause of vertical double vision often treated by strabismus surgery. This aim will evaluates EOM function by multipositional magnetic resonance imaging to test an alternative hypotheses that SO palsy often is not caused by EOM weakness, but instead by benign misdirection of a cranial nerve, and may improve the way strabismus surgery on the EOMs can correct the double vision. Aim II will characterize the dynamic way the eyeball is deformed by eye movements. Everyday eye movements impose much greater mechanical forces on critical parts of the eye than does elevated intraocular pressure. We will investigate by in living people the mechanical effects of fast and slow eye rotations on the retina, optic disc, and other parts of the eye during horizontal and vertical eye rotations, using high speed confocal scanning laser imaging and optical coherence tomography. We propose that the eye deformation, especially during rapid eye movements ubiquitous in daily life, may accumulate over time to create repetitive strain injury contributing to glaucoma and high myopia. Healthy children and adults will be compared with subjects who have glaucoma or high myopia. Effects of eye movement will also be studied ex vivo by precision 3D optical imaging of fresh human eye bank specimens, with and without history of glaucoma, subjected to mechanical tension on the optic nerve that mimic effects of the eye movements imaged in the living subjects. Aim III will use computer simulation to model and validate the effects of mechanical strain in the eye during eye movements. We will the measured time-dependent mechanical properties of donated, post-mortem human eyes to develop finite element models (FEMs) using modern engineering methods for computational simulation to predict how rapid eye movements cause time-varying mechanical strains in the optic nerve and outer eye wall that may produce glaucoma & the ocular deformities underlying extreme myopia. Using FEMs, we will explore in theory possible options for treatment of glaucoma and axial high myopia that might be accomplished by scleral cross-linking, and medical treatment of orbital tissues, and strabismus surgical techniques.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $670,248 )
2025	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Vision Research	002	35	5/29/2025	NON-COMPETING CONTINUATION	$670,248
2025	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Vision Research	001	34	2/24/2025	COMPETING CONTINUATION	$218,232
2025	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Vision Research	000	33	2/24/2025	NON-COMPETING CONTINUATION	-$218,232
														Subtotal = $670,248

Issue Date FY: 2024 ( Subtotal = $668,209 )
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Vision Research	001	34	5/24/2024	COMPETING CONTINUATION	$668,209
2024	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Vision Research	000	33	5/17/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $668,209

Issue Date FY: 2023 ( Subtotal = $591,297 )
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Vision Research	000	33	5/15/2023	NON-COMPETING CONTINUATION	$591,297
														Subtotal = $591,297

Issue Date FY: 2022 ( Subtotal = $584,906 )
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Vision Research	000	32	5/19/2022	NON-COMPETING CONTINUATION	$584,906
														Subtotal = $584,906

Issue Date FY: 2021 ( Subtotal = $584,907 )
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	002	31	4/23/2021	NON-COMPETING CONTINUATION	$584,907
2021	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Vision Research	001	30	3/10/2021	COMPETING CONTINUATION	$202,016
2021	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Vision Research	000	29	3/10/2021	NON-COMPETING CONTINUATION	-$202,016
														Subtotal = $584,907

Issue Date FY: 2020 ( Subtotal = $622,245 )
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	000	30	3/27/2020	COMPETING CONTINUATION	$622,245
														Subtotal = $622,245

Issue Date FY: 2019 ( Subtotal = $585,719 )
2019	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	000	29	5/16/2019	NON-COMPETING CONTINUATION	$585,719
														Subtotal = $585,719

Issue Date FY: 2018 ( Subtotal = $653,174 )
2018	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	001	28	9/19/2018	SUPPLEMENT FOR EXPANSION	$68,688
2018	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	000	28	4/9/2018	NON-COMPETING CONTINUATION	$584,486
														Subtotal = $653,174

Issue Date FY: 2017 ( Subtotal = $590,499 )
2017	2017	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	000	27	3/30/2017	NON-COMPETING CONTINUATION	$531,450
2017	2017	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	001	27	7/10/2017	NON-COMPETING CONTINUATION	$59,049
														Subtotal = $590,499

Issue Date FY: 2016 ( Subtotal = $577,151 )
2016	2016	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	000	26	4/28/2016	COMPETING CONTINUATION	$577,151
														Subtotal = $577,151

Issue Date FY: 2015 ( Subtotal = $570,927 )
2015	2015	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	000	25	4/2/2015	NON-COMPETING CONTINUATION	$570,927
														Subtotal = $570,927

Issue Date FY: 2014 ( Subtotal = $570,927 )
2014	2014	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	000	24	4/23/2014	NON-COMPETING CONTINUATION	$570,927
														Subtotal = $570,927

Issue Date FY: 2013 ( Subtotal = $553,450 )
2013	2013	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	000	23	5/2/2013	NON-COMPETING CONTINUATION	$524,321
2013	2013	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	001	23	6/10/2013	NON-COMPETING CONTINUATION	$29,129
														Subtotal = $553,450

Issue Date FY: 2012 ( Subtotal = $582,579 )
2012	2012	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	000	22	4/2/2012	NON-COMPETING CONTINUATION	$582,579
														Subtotal = $582,579

Issue Date FY: 2011 ( Subtotal = $582,579 )
2011	2011	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	000	21	4/18/2011	COMPETING CONTINUATION	$582,579
														Subtotal = $582,579

Issue Date FY: 2010 ( Subtotal = $557,252 )
2010	2010	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	000	20	4/21/2010	NON-COMPETING CONTINUATION	$557,252
														Subtotal = $557,252

Issue Date FY: 2009 ( Subtotal = $546,487 )
2009	2009	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	000	19	4/10/2009	NON-COMPETING CONTINUATION	$546,487
														Subtotal = $546,487

Issue Date FY: 2008 ( Subtotal = $519,959 )
2008	2008	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	000	18	5/9/2008	NON-COMPETING CONTINUATION	$519,959
														Subtotal = $519,959

Issue Date FY: 2007 ( Subtotal = $515,117 )
2007	2007	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	10920 WILSHIRE BLVD, 5TH FLOOR	LOS ANGELES	CA	90024	LOS ANGELES	USA	Vision Research	000	17	9/12/2007	NON-COMPETING CONTINUATION	$515,117
														Subtotal = $515,117

Issue Date FY: 2006 ( Subtotal = $508,299 )
2006	2006	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	10920 WILSHIRE BLVD, 5TH FLOOR	LOS ANGELES	CA	90024	LOS ANGELES	USA	Vision Research	000	16	4/10/2006	COMPETING CONTINUATION	$508,299
														Subtotal = $508,299

Issue Date FY: 2005 ( Subtotal = $485,421 )
2005	2005	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	10920 WILSHIRE BLVD, 5TH FLOOR	LOS ANGELES	CA	90024	LOS ANGELES	USA	Vision Research	000	15	12/30/2004	NON-COMPETING CONTINUATION	$485,421
														Subtotal = $485,421

Grand Total All Awards = $15,257,575

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Biomechanical Analysis in Strabismus Surgery

Award Number: R01EY008313

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/06/1991

PERIOD OF PERFORMANCE END DATE: 05/31/2029

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