Monday, February 16, 2026 2/16/2026

MOLECULAR GENETIC DISSECTION OF PHOTORECEPTOR FUNCTION

Award Number: R01EY000033
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 10/01/1974
PERIOD OF PERFORMANCE END DATE: 09/29/2009

Group Awards By:

View Award Description

MOLECULAR GENETIC DISSECTION OF PHOTORECEPTOR FUNCTION - DESCRIPTION (provided by applicant): The long-term objective of the project is to carry out molecular genetic investigations of photoreceptor processes using electroretinogram (ERG)-defective mutants of Drosophila. There are two main, related topics of investigation proposed in this application. One is to elucidate the mechanisms of excitation and regulation of the light-activated channel of Drosophila, TRP, by identifying proteins that potentially interact with TRP channels and attempting to clarify their functions. The other is to isolate and characterize two novel genes that, when defective, cause striking photoreceptor degeneration. The study of the excitation mechanism of the TRP channel is important, not only because it is the most important unsolved problem in Drosophila photoreceptor excitation, but also because the TRP protein has over 20 related proteins in mammals. At least two of these are expressed in the eye. Biological functions now beginning to be uncovered for some of these are both diverse and important. They range from temperature detection to tumor suppression, and some even show promise as early detectors of prostate cancer. Elucidation of how the Drosophila TRP channels work would provide insights into how these related mammalian channels work. Understanding how these mammalian channels function, in turn, could have important consequences in the therapy and management of health-related problems. Studying novel retinal degeneration genes of Drosophila are important because inherited retinal degeneration remains one of the most important causes of blindness in humans and the mechanisms of retinal degeneration often are conserved among different species. Drosophila is used in these studies because molecular and genetic studies can be much more effectively and precisely carried out in this organism than in any other animal organisms. Moreover, it has now been shown over and over again what is learned in Drosophila provide important insights into the corresponding processes in mammals.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $0 )
2009	2008	PURDUE UNIVERSITY	610 PURDUE HALL	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Vision Research	000	39	9/16/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2008 ( Subtotal = $457,743 )
2008	2008	PURDUE UNIVERSITY	610 PURDUE HALL	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Vision Research	000	39	11/30/2007	NON-COMPETING CONTINUATION	$457,743
														Subtotal = $457,743

Issue Date FY: 2007 ( Subtotal = $456,269 )
2007	2007	PURDUE UNIVERSITY	610 PURDUE HALL	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Vision Research	000	38	1/24/2007	NON-COMPETING CONTINUATION	$456,269
														Subtotal = $456,269

Issue Date FY: 2006 ( Subtotal = $448,268 )
2006	2006	PURDUE UNIVERSITY	610 PURDUE HALL	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Vision Research	000	37	1/19/2006	NON-COMPETING CONTINUATION	$448,268
														Subtotal = $448,268

Issue Date FY: 2005 ( Subtotal = $448,552 )
2005	2005	PURDUE UNIVERSITY	SPONS PROGRAMS-1063 HOVDE HALL	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Vision Research	000	36	12/6/2004	NON-COMPETING CONTINUATION	$448,552
														Subtotal = $448,552

Issue Date FY: 2004 ( Subtotal = $426,387 )
2004	2004	PURDUE UNIVERSITY	SPONS PROGRAMS-1063 HOVDE HALL	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Vision Research	000	35	11/28/2003	COMPETING CONTINUATION	$426,387
														Subtotal = $426,387

Issue Date FY: 2003 ( Subtotal = $375,279 )
2003	2003	PURDUE RESEARCH FOUNDATION	SPONS PROGRAMS-1063 HOVDE HALL	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Vision Research	000	34		NON-COMPETING CONTINUATION	$375,279
														Subtotal = $375,279

Issue Date FY: 2002 ( Subtotal = $366,353 )
2002	2002	PURDUE RESEARCH FOUNDATION	SPONS PROGRAMS-1063 HOVDE HALL	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Vision Research	000	33	12/3/2001	NON-COMPETING CONTINUATION	$366,353
														Subtotal = $366,353

Issue Date FY: 2001 ( Subtotal = $357,683 )
2001	2001	PURDUE RESEARCH FOUNDATION	SPONS PROGRAMS-1063 HOVDE HALL	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Vision Research	000	32	11/27/2000	NON-COMPETING CONTINUATION	$357,683
														Subtotal = $357,683

Issue Date FY: 2000 ( Subtotal = $369,267 )
2000	2000	PURDUE RESEARCH FOUNDATION	610 PURDUE HALL	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Vision Research	000	31	2/9/2000	COMPETING CONTINUATION	$369,267
														Subtotal = $369,267

Grand Total All Awards = $3,705,801

Top

All Categories

About

Search

Reports

Data Submission

Award Information

MOLECULAR GENETIC DISSECTION OF PHOTORECEPTOR FUNCTION

Award Number: R01EY000033

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 10/01/1974

PERIOD OF PERFORMANCE END DATE: 09/29/2009

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer