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Neighborhood and individual environmental risk factors in early life and -omics biomarkers for kidney function trajectories across childhood and adulthood

Award Number: R01ES038119
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/23/2026
PERIOD OF PERFORMANCE END DATE: 04/22/2030

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Neighborhood and individual environmental risk factors in early life and -omics biomarkers for kidney function trajectories across childhood and adulthood - PROJECT SUMMARY/ABSTRACT Chronic kidney disease (CKD) and hypertension (HTN) are substantial public health concerns in the US and are important risk factors for other adverse outcomes including acute kidney injury and premature mortality. CKD and HTN are typically diagnosed later in life, yet our understanding of the prenatal and early life environ- mental determinants of reduced kidney function and HTN across childhood and early adulthood remains incipi- ent. This research, however, faces several barriers including lack of assessment of both neighborhood- and individual-level environmental stressors at specific early life stages coupled with long-term follow-up from birth to early adulthood. This project will address these research gaps by leveraging high-quality data from Project Viva, an ongoing longitudinal prospective pre-birth cohort of mother-child pairs followed since pregnancy. The overall goals of the proposed project are to examine the extent to which early-life exposure to disadvantaged neighborhood contexts and nephrotoxicants (i.e., air pollutants and metals) leads to later life kidney dysfunc- tion and higher blood pressure (BP). The investigators will: (Aim 1) examine associations of early-life neighbor- hood environment with kidney function and BP across childhood and early adulthood; (Aim 2) assess associa- tions of individual-level early-life exposure to candidate nephrotoxicants with kidney function and BP from mid- childhood to early adulthood; and (Aim 3) characterize urinary proteomic signatures underlying altered kidney function and BP trajectory from childhood to early adulthood, and examine these signatures as potential mark- ers of toxicant exposure. This innovative proposal will be the first to examine both neighborhood- and individ- ual-level environmental determinants of kidney function and BP trajectories. We will identify actionable risk fac- tors and molecular signatures to identify high-risk individuals and pinpoint when primordial prevention efforts have the greatest potential to prevent future CKD and HTN.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $3,796,422 )
2026	2026	HARVARD PILGRIM HEALTH CARE INC	1 WELLNESS WAY	CANTON	MA	02021	NORFOLK	USA	Environmental Health	000	1	4/27/2026	NEW	$3,796,422
														Subtotal = $3,796,422

Grand Total All Awards = $3,796,422

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Neighborhood and individual environmental risk factors in early life and -omics biomarkers for kidney function trajectories across childhood and adulthood

Award Number: R01ES038119

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/23/2026

PERIOD OF PERFORMANCE END DATE: 04/22/2030

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