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Children’s Cardiovascular Health and the Impacts of Heat Stress and Wildfire Smoke

Award Number: R01ES036185
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/23/2024
PERIOD OF PERFORMANCE END DATE: 11/30/2029

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Children’s Cardiovascular Health and the Impacts of Heat Stress and Wildfire Smoke - Over the last decade, the US has experienced extreme temperatures and heat events, while at the same time, wildfires continue to have devastating effects. As these trends continue across the US, the impacts of these exposures on children’s health remain largely unknown. Exposure to heat stress and wildfire smoke are emerging weather-related threats that have been strongly linked to adverse cardiovascular health outcomes and mortality in adults. Given that childhood is a critical period in determining life-long cardiovascular health, and children are uniquely sensitive to environmental insults, it is crucial to develop a greater understanding of the cardiovascular impacts of extreme heat and of wildfire smoke, particularly during sensitive periods of development. Further, weather-related exposures often co-occur and evidence suggests that the combined impacts of heat stress and wildfires may heighten the effects of each of these exposures on cardiovascular health, thus considering their cumulative effects is important to fully capture the extent of their likely impacts. Lastly, evaluating the efficacy of household and community adaptation strategies at buffering those health effects in children may provide further insight into intervention opportunities to protect the most impacted. In this proposal, we will investigate whether greater individual and combined exposures to heat stress and wildfire smoke over the life course and during sensitive developmental windows in pregnancy and childhood are associated with poorer cardiovascular health profiles in mid-childhood. We will leverage the MADRES prospective cohort of mother-child pairs to annually evaluate children between ages 6 to 9 years, using a comprehensive set of cardiovascular health measures, including blood pressure, pulse wave velocity, resting heart rate, blood lipids and urinary biomarkers of oxidative stress. We will employ novel statistical modeling methods to evaluate combined exposures during sensitive developmental windows, as well as the role of multifaceted adaptation strategies at the household (air conditioning, filtration) and community levels (urban heat islands, tree cover, cooling centers, etc.) in modifying the impacts of weather-related exposures on child cardiovascular health. This work will inform targeted interventions to reduce cardiovascular health impacts of heat stress and wildfire exposures, increase adaptive capacity, and protect long term cardiovascular health among children.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $669,373 )
2026	2026	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Environmental Health	000	2	2/24/2026	NON-COMPETING CONTINUATION	$669,373
														Subtotal = $669,373

Issue Date FY: 2025 ( Subtotal = $674,078 )
2025	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Environmental Health	000	1	1/23/2025	NEW	$674,078
2025	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Environmental Health	001	1	9/26/2025	NEW	$0
														Subtotal = $674,078

Grand Total All Awards = $1,343,451

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Children’s Cardiovascular Health and the Impacts of Heat Stress and Wildfire Smoke

Award Number: R01ES036185

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/23/2024

PERIOD OF PERFORMANCE END DATE: 11/30/2029

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