Tuesday, February 17, 2026 2/17/2026

Prenatal and infant household air pollution exposure, the human microbiome and virome, and childhood lung function: the GRAPHS randomized controlled trial

Award Number: R01ES035791
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/17/2025
PERIOD OF PERFORMANCE END DATE: 11/30/2029

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Prenatal and infant household air pollution exposure, the human microbiome and virome, and childhood lung function: the GRAPHS randomized controlled trial - Project summary In low- and middle-income countries ~2.8 billion people are exposed daily to smoke from cooking fires, termed household air pollution (HAP), resulting in an estimated 2.3M deaths and 91.4M disability adjusted life years in 2019. A large proportion of HAP-attributable deaths are due to respiratory disease over the life course. Establishment of lung health in childhood is critical to reduce risk for future respiratory disease. We propose to build on an existing pregnancy cohort in Ghana – the Ghana Randomized Air Pollution and Health Study, or GRAPHS – to assess how randomized early life air pollution exposure programs subsequent microbiome and virome over childhood, and how these changes are further associated with lung function and lung function growth. We will use well-established, validated methods to assess these outcomes. In the long run, our research will help build the evidence base for public health interventions to reduce HAP exposure-associated respiratory disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,349,160 )
2026	2026	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	001	2	1/29/2026	SUPPLEMENT FOR EXPANSION	$118,029
2026	2026	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	000	2	1/27/2026	NON-COMPETING CONTINUATION	$1,231,131
														Subtotal = $1,349,160

Issue Date FY: 2025 ( Subtotal = $1,377,026 )
2025	2025	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	000	1	1/16/2025	NEW	$1,377,026
														Subtotal = $1,377,026

Grand Total All Awards = $2,726,186

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Prenatal and infant household air pollution exposure, the human microbiome and virome, and childhood lung function: the GRAPHS randomized controlled trial

Award Number: R01ES035791

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/17/2025

PERIOD OF PERFORMANCE END DATE: 11/30/2029

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