Thursday, July 3, 2025 7/3/2025

SEMIPARAMETRIC METHODS FOR MODELING OF TIME-DEPENDENT ENVIRONMENTAL EXPOSURES

Award Number: R01ES032808
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/09/2021
PERIOD OF PERFORMANCE END DATE: 01/31/2026

Group Awards By:

View Award Description

SEMIPARAMETRIC METHODS FOR MODELING OF TIME-DEPENDENT ENVIRONMENTAL EXPOSURES - SEMIPARAMETRIC METHODS FOR MODELING OF TIME-DEPENDENT ENVIRONMENTAL EXPOSURES Abstract Countless environmental exposures throughout the human life course and influence human development and susceptibility to disease. Assessing how multiple exposures synergize or antagonize each other to affect human health is a powerful approach to understanding the all-around impact of environmental exposures. Such approach will be needed in the new paradigm of exposome research, which encompass all non-genetic causes for diseases, from external natural to social environments and from internal macro- to microenvironments. However, many environmental investigations are challenged by the special data structure and characteristics of time-dependent exposures. In particular, multiple environmental exposures: 1) are inter- correlated; 2) are time-dependent; 3) exhibit time-varying effects; 4) have heterogeneous effects; and 5) demonstrate complex and nonlinear exposure-response relationships. The limiting availability of statistical models and analytical tools to handle these challenges hinder our ability to make inference or draw conclusions about the effects of multiple exposures on human health. Building upon our experience developing statistical methodologies and motivated by the challenges encountered in many of our collaborations in environmental research, we propose to develop and implement novel statistical methods to address important scientific questions in environmental health research, specifically through the following aims: 1) evaluate the effects of time-dependent environmental exposures on time-invariant health outcomes and identify critical windows of vulnerability; 2) characterize the effects of time-dependent environmental exposures on time-to- event and longitudinal outcomes; 3) investigate the heterogeneous impacts by environmental exposures on subpopulations; and 4) develop, distribute, and support open-source software packages for the proposed methods. All proposed models, estimation, and testing procedures will be investigated through analytical approaches, theoretical inference, numerical simulations, and applications to multiple datasets from approved human-subject studies. Upon its completion, the proposed project will provide new statistical methods that both support ongoing collaborations to address critical scientific questions and enable the environmental health research community to better assess the impact of time-dependent exposures.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $381,375 )
2025	2025	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Environmental Health	000	5	1/20/2025	NON-COMPETING CONTINUATION	$381,375
														Subtotal = $381,375

Issue Date FY: 2024 ( Subtotal = $381,375 )
2024	2024	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Environmental Health	000	4	1/29/2024	NON-COMPETING CONTINUATION	$381,375
														Subtotal = $381,375

Issue Date FY: 2023 ( Subtotal = $381,375 )
2023	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Environmental Health	000	3	1/23/2023	NON-COMPETING CONTINUATION	$381,375
														Subtotal = $381,375

Issue Date FY: 2022 ( Subtotal = $343,238 )
2022	2022	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Environmental Health	000	2	1/18/2022	NON-COMPETING CONTINUATION	$343,238
														Subtotal = $343,238

Issue Date FY: 2021 ( Subtotal = $343,238 )
2021	2021	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Environmental Health	000	1	4/8/2021	NEW	$343,238
														Subtotal = $343,238

Grand Total All Awards = $1,830,601

Top

All Categories

About

Search

Reports

Data Submission

Award Information

SEMIPARAMETRIC METHODS FOR MODELING OF TIME-DEPENDENT ENVIRONMENTAL EXPOSURES

Award Number: R01ES032808

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/09/2021

PERIOD OF PERFORMANCE END DATE: 01/31/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer