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The Impact of Drought on Arsenic Exposure and Cardiometabolic Outcomes in a Rural Aging Population: Diversity Supplement

Award Number: R01ES032612
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary / Abstract Droughts are an important natural disaster but the health implications for elderly populations in the United States have not been extensively studied. This study seeks to provide evidence on the cardiometabolic health risks posed by drought. Droughts can contribute to groundwater over-pumping, and this may in turn lead to arsenic release from aquifer clays into drinking water sources. The impacts of drought on arsenic exposure and resultant health outcomes in human populations are potentially important and this study seeks to address that knowledge gap. We propose to conduct a retrospective cohort study using data from the San Luis Valley Diabetes Study, as well as hydrogeological measurements of water and environmental conditions in the San Luis Valley, to clarify relationships between drought, arsenic in water, arsenic exposure (as measured by urine biomarker), and cardiometabolic health outcomes including incident diabetes (DM), incident cardiovascular disease (CVD), and all-cause mortality. This work is community-engaged and includes a K12 outreach component. Aim 1 quantifies the relationship of drought to individual arsenic exposures and thence to incident CVD, incident DM, and mortality. Aim 2 generates a model for groundwater arsenic as a function of hydrological predictors using machine learning approaches, and uses this to explore relationships between drought, modeled water arsenic and the outcomes of Aim 1. Aim 3 estimates the association between cumulative arsenic exposure and incident CVD, incident DM, and mortality, using a nested case-control design and predictions over time of arsenic exposure from the Aim 2 model. Aim 4 is a simulation study projecting future CVD and DM outcomes under different scenarios of drought conditions, with and without counterfactual interventions to reduce drinking water arsenic.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $53,525 )
2025	2025	THE REGENTS OF THE UNIV. OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Environmental Health	000	4	12/17/2024	SUPPLEMENT FOR EXPANSION	$53,525
														Subtotal = $53,525

Issue Date FY: 2024 ( Subtotal = $573,146 )
2024	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Environmental Health	000	4	5/28/2024	NON-COMPETING CONTINUATION	$573,146
														Subtotal = $573,146

Issue Date FY: 2023 ( Subtotal = $586,542 )
2023	2023	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Environmental Health	000	3	6/20/2023	NON-COMPETING CONTINUATION	$586,542
														Subtotal = $586,542

Issue Date FY: 2022 ( Subtotal = $600,295 )
2022	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Environmental Health	000	2	5/31/2022	NON-COMPETING CONTINUATION	$600,295
														Subtotal = $600,295

Issue Date FY: 2021 ( Subtotal = $671,536 )
2021	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Environmental Health	000	1	8/5/2021	NEW	$671,536
														Subtotal = $671,536

Grand Total All Awards = $2,485,044

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The Impact of Drought on Arsenic Exposure and Cardiometabolic Outcomes in a Rural Aging Population: Diversity Supplement

Award Number: R01ES032612

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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