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Exposure to phthalate mixtures in pregnancy and long-term consequences for maternal metabolic and hormonal status

Award Number: R01ES032227
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Exposure to phthalate mixtures in pregnancy and long-term consequences for maternal metabolic and hormonal status - PROJECT SUMMARY As many as 86% of women will give birth to at least one child, and pregnancy has long-term consequences for women’s metabolic health, including obesity and glucose homeostasis. However, little is understood about modifiable factors in pregnancy that can improve women’s health postnatally. Phthalates are endocrine disrupting chemicals to which almost all women are exposed from personal care products and food contact materials. Recent evidence suggests that phthalate exposure in pregnancy is associated with disrupted gestational weight gain and glucose homeostasis in mothers. However, whether these metabolic disruptions persist postnatally is not currently known. Therefore, we will leverage an ongoing pregnancy cohort study that has already assessed phthalate concentrations in pregnant women to follow these mothers and ask whether prenatal phthalate exposure is associated with disrupted adiposity and metabolism 4-7 years later. Importantly, we will assess cumulative exposure to a complex mixture of phthalates, since pregnant women have concurrent exposure to numerous phthalates. Phthalates can disrupt estrogen biosynthesis, and several studies (including our preliminary work) suggest that phthalate exposures are associated with disrupted estrogen levels in pregnant women. This is concerning in pregnancy because estrogens have numerous critical functions in pregnant women, including implantation, fetal nutrient transport, and parturition. While estrogenic disruption by phthalates in pregnancy could have deleterious consequences for fetal development and pregnancy outcomes, whether these hormonal disruptions persist postnatally to impact maternal health is not known. Estrogen disruption that persists after pregnancy is potentially harmful for women’s life-long health because in non-pregnant women, estrogens regulate maternal metabolic health, including weight, metabolic efficiency, insulin sensitivity, and appetite. Therefore, the current study will also assess whether exposure to a complex mixture of phthalates in pregnancy is associated with disrupted estrogen levels in women postnatally, and whether these prenatal endocrine disruptions that persists postnatally drive maternal metabolic dysregulations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $415,266 )
2025	2025	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	000	5	4/18/2025	NON-COMPETING CONTINUATION	$415,266
														Subtotal = $415,266

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	000	4	6/18/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $413,527 )
2023	2023	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	000	4	4/11/2023	NON-COMPETING CONTINUATION	$413,527
														Subtotal = $413,527

Issue Date FY: 2022 ( Subtotal = $420,097 )
2022	2022	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	000	3	5/11/2022	NON-COMPETING CONTINUATION	$420,097
														Subtotal = $420,097

Issue Date FY: 2021 ( Subtotal = $415,848 )
2021	2021	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	000	2	4/12/2021	NON-COMPETING CONTINUATION	$415,848
														Subtotal = $415,848

Issue Date FY: 2020 ( Subtotal = $445,375 )
2020	2020	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	000	1	8/6/2020	NEW	$445,375
														Subtotal = $445,375

Grand Total All Awards = $2,110,113

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Exposure to phthalate mixtures in pregnancy and long-term consequences for maternal metabolic and hormonal status

Award Number: R01ES032227

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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