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Impacts of Benzo[a]pyrene on Microbiome Development across Lifespan and Generations and the Behavioral Consequences

Award Number: R01ES030226
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary / Abstract This project will test the innovative hypothesis that developmental exposure to environmental toxicants can alter gut microbiome assembly and succession to consequently result in impaired behavior and cognition. The alarming rise in behavioral and cognitive disorders is linked to early life exposure to environmental chemicals, such as benzo[a]pyrene (BAP), the globally ubiquitous pollutant on which this project focuses. While the mechanisms underlying these impairments remain poorly defined, prior work implicates a dysbiotic gut microbiome. This project will define how early life exposure to BAP alters the development of gut microbiome structure and function and how these alterations relate to behavior. It will also couple high-throughput culturing with a scalable, germ-free animal model (zebrafish) to comprehensively measure the behavioral impacts of BAP-sensitive gut microbes and their metabolites. This project also quantifies how developmental BAP exposure alters the microbiome-behavior axis in subsequent generations. Consequently, the proposed research holds great potential to transform our understanding of the causes of behavior impairment and reveal new candidates, in the forms of gut microbes and metabolites, for normalizing behavior development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $477,733 )
2023	2023	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	Environmental Health	001	5	1/26/2023	SUPPLEMENT FOR EXPANSION	$74,811
2023	2023	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	Environmental Health	000	5	1/24/2023	NON-COMPETING CONTINUATION	$402,922
														Subtotal = $477,733

Issue Date FY: 2022 ( Subtotal = $457,911 )
2022	2022	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	Environmental Health	001	4	3/24/2022	SUPPLEMENT FOR EXPANSION	$62,339
2022	2022	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	Environmental Health	000	4	1/12/2022	NON-COMPETING CONTINUATION	$395,572
														Subtotal = $457,911

Issue Date FY: 2021 ( Subtotal = $410,272 )
2021	2021	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	Environmental Health	000	3	1/18/2021	NON-COMPETING CONTINUATION	$410,272
														Subtotal = $410,272

Issue Date FY: 2020 ( Subtotal = $388,222 )
2020	2020	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	Environmental Health	000	2	1/21/2020	NON-COMPETING CONTINUATION	$388,222
														Subtotal = $388,222

Issue Date FY: 2019 ( Subtotal = $405,872 )
2019	2019	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	Environmental Health	000	1	1/23/2019	NEW	$405,872
														Subtotal = $405,872

Grand Total All Awards = $2,140,010

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Impacts of Benzo[a]pyrene on Microbiome Development across Lifespan and Generations and the Behavioral Consequences

Award Number: R01ES030226

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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