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Chemical Probes to Study Formaldehyde Biology

Award Number: R01ES028096
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2017
PERIOD OF PERFORMANCE END DATE: 01/31/2027

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Chemical Probes to Study Formaldehyde Biology - Project Summary/Abstract Formaldehyde (FA) is a ubiquitous small molecule that plays a diverse array of important roles in human health and disease. As the simplest aldehyde and reactive carbonyl species, FA is a major environmental toxin that is classified as a carcinogen, and FA exposure is also connected to a variety of other serious diseases ranging from chronic liver disorders to cancer, cardiovascular and neurodegenerative diseases, and diabetes. At the same time, the body produces this reactive carbonyl species during normal physiology, primarily through enzymatic demethylation events as well as through the one- carbon cycle. We seek to develop and apply new chemical reagents for selective imaging and proteomics of FA in living systems to identify its molecular sources and targets, with the long-term goal of understanding how and in what context this reactive small molecule contributes to both physiology and disease. This application will focus on new technologies to enable selective molecular imaging of FA in biological models to study sources of FA generation and metabolism, with accompanying chemoproteomics methods to identify targets of FA in genetic models where FA metabolism is compromised. Specific aims include developing new fluorescent probes for subcellular imaging of FA and enzymatic oxidation to formate, applying unbiased activity-based protein profiling (ABPP) methods to identify cysteine-derived targets of FA in whole proteomes, and performing biochemical and cellular studies to decipher roles of FA targets in regulating one-carbon metabolism.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $502,007 )
2025	2025	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Environmental Health	004	10	2/17/2025	NON-COMPETING CONTINUATION	$502,007
2025	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Environmental Health	002	8	2/12/2025	NON-COMPETING CONTINUATION	-$1
2025	2024	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Environmental Health	000	9	1/22/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2025	2024	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Environmental Health	003	9	2/12/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$44,511
2025	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Environmental Health	001	7	2/12/2025	NON-COMPETING CONTINUATION	-$44,510
														Subtotal = $502,007

Issue Date FY: 2024 ( Subtotal = $509,203 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Environmental Health	000	8	2/6/2024	NON-COMPETING CONTINUATION	$477,840
2024	2024	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Environmental Health	002	9	8/28/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$509,202
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Environmental Health	001	8	8/9/2024	NON-COMPETING CONTINUATION	-$477,839
														Subtotal = $509,203

Issue Date FY: 2023 ( Subtotal = $476,984 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Environmental Health	002	7	1/27/2023	NON-COMPETING CONTINUATION	$476,984
2023	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Environmental Health	001	6	11/28/2022	COMPETING CONTINUATION	$246,805
2023	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Environmental Health	000	5	11/28/2022	NON-COMPETING CONTINUATION	-$246,805
														Subtotal = $476,984

Issue Date FY: 2022 ( Subtotal = $483,332 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Environmental Health	001	6	3/31/2022	COMPETING CONTINUATION	$483,332
2022	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Environmental Health	000	5	3/24/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $483,332

Issue Date FY: 2021 ( Subtotal = $313,739 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Environmental Health	000	5	5/6/2021	NON-COMPETING CONTINUATION	$313,739
														Subtotal = $313,739

Issue Date FY: 2020 ( Subtotal = $323,269 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Environmental Health	000	4	6/2/2020	NON-COMPETING CONTINUATION	$323,269
														Subtotal = $323,269

Issue Date FY: 2019 ( Subtotal = $332,520 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Environmental Health	000	3	5/30/2019	NON-COMPETING CONTINUATION	$332,520
														Subtotal = $332,520

Issue Date FY: 2018 ( Subtotal = $341,503 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Environmental Health	000	2	5/30/2018	NON-COMPETING CONTINUATION	$341,503
														Subtotal = $341,503

Issue Date FY: 2017 ( Subtotal = $350,223 )
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Environmental Health	000	1	8/30/2017	NEW	$350,223
														Subtotal = $350,223

Grand Total All Awards = $3,632,780

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Chemical Probes to Study Formaldehyde Biology

Award Number: R01ES028096

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2017

PERIOD OF PERFORMANCE END DATE: 01/31/2027

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