Thursday, November 21, 2024 11/21/2024

Role of alveolar macrophage in omega-3 fatty acid amelioration of silica-triggered autoimmunity.

Award Number: R01ES027353
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Summary: "Role of Alveolar Macrophage in Omega-3 Fatty acid Amelioration of Silica-Triggered Autoimmunity” While heredity is a primary predisposing factor for autoimmunity, cumulative exposures to environmental factors such as toxic stressors and diet greatly impact latency and severity autoimmune diseases such as lupus. Our goal is to understand how lupus triggering by an ubiquitous environmental toxicant can be prevented by dietary modulation of cellular lipids. This goal is predicated on preliminary studies revealing that 1)airway exposure to crystalline silica, a recognized autoimmune disease risk factor, triggers early onset of systemic autoimmunity and glomerulonephritis in the lupus-prone female NZBWF1 mouse and 2)supplementing their diets with the omega-3 fatty acid docosahexaenoic acid (DHA), a well-known dietary supplement extracted from cold-water fish, dose-dependently blocks this triggering. Here, we will employ in vitro, ex vivo, and in vivo approaches to test the hypothesis that DHA consumption prevents silica- triggered autoimmunity by suppressing inflammatory mediator production, death, and self-antigen release in alveolar macrophages of NZBWF1 mice. Revealing DHA mechanisms against silica- triggered lupus will bring novel insights into how respiratory toxicants initiate lupus and subsequent flaring via lung as well as how manipulating cellular lipids through diet can be exploited to prevent environmental triggering of human autoimmune disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $666,325 )
2025	2025	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	001	8	11/4/2024	SUPPLEMENT FOR EXPANSION	$100,328
2025	2025	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	000	8	11/1/2024	NON-COMPETING CONTINUATION	$565,997
														Subtotal = $666,325

Issue Date FY: 2024 ( Subtotal = $699,767 )
2024	2024	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	000	7	10/30/2023	NON-COMPETING CONTINUATION	$565,997
2024	2024	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	003	7	10/31/2023	SUPPLEMENT FOR EXPANSION	$133,770
2024	2023	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	002	6	10/30/2023	COMPETING CONTINUATION	$6,808
2024	2021	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	001	5	10/30/2023	NON-COMPETING CONTINUATION	-$6,808
														Subtotal = $699,767

Issue Date FY: 2023 ( Subtotal = $614,740 )
2023	2023	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	002	6	7/12/2023	SUPPLEMENT FOR EXPANSION	$33,443
2023	2023	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	001	6	12/14/2022	COMPETING CONTINUATION	$581,297
2023	2021	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	000	5	12/2/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $614,740

Issue Date FY: 2021 ( Subtotal = $416,246 )
2021	2021	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	000	5	7/13/2021	NON-COMPETING CONTINUATION	$416,246
														Subtotal = $416,246

Issue Date FY: 2020 ( Subtotal = $461,699 )
2020	2020	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	000	4	5/19/2020	NON-COMPETING CONTINUATION	$461,699
														Subtotal = $461,699

Issue Date FY: 2019 ( Subtotal = $441,120 )
2019	2019	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	000	3	6/5/2019	NON-COMPETING CONTINUATION	$441,120
														Subtotal = $441,120

Issue Date FY: 2018 ( Subtotal = $441,120 )
2018	2018	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	000	2	5/14/2018	NON-COMPETING CONTINUATION	$441,120
														Subtotal = $441,120

Issue Date FY: 2017 ( Subtotal = $481,050 )
2017	2017	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	000	1	5/11/2017	NEW	$481,050
														Subtotal = $481,050

Grand Total All Awards = $4,222,067

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Role of alveolar macrophage in omega-3 fatty acid amelioration of silica-triggered autoimmunity.

Award Number: R01ES027353

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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