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Revealing environmental chemical exposome in a diverse prenatal population and relationships to maternal and perinatal health (REVEAL)

Award Number: R01ES027051
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2016
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Revealing environmental chemical exposome in a diverse prenatal population and relationships to maternal and perinatal health (REVEAL) - ABSTRACT - Revealing environmental chemical exposome in a diverse prenatal population and relationships to maternal and perinatal health (REVEAL) Our renewal application builds on our original R01 by advancing analytical chemistry and computational techniques to characterize more fully the prenatal chemical exposome and its links to adverse maternal and perinatal health outcomes (e.g., gestational diabetes, preterm birth, and low birthweight). Prevalence of these outcomes has increased and is linked to chemical exposures in the US population. Prenatal exposures to a broad range of environmental chemicals, including plastic related chemicals and per- and polyfluoroalkyl substances (PFAS), have been shown to adversely affect health, but technological challenges have left significant data gaps hindering our ability to characterize environmental exposures and drivers of disease. Over 350,000 chemicals and compound mixtures are registered for production worldwide, and thousands of high–production volume chemicals are used extensively in the US, yet human biomonitoring capacity covers a very small fraction of the chemical exposome. In our previous R01 we pioneered a nontargeted analysis (NTA) workflow, with significantly improved computational and analytical methods using high-resolution mass spectrometry (HRMS) in a demographically diverse population of maternal-newborn pairs. We were the first to identify multiple chemicals in maternal and newborn sample used in high volumes in the US not previously detected in human blood samples including chemicals used in personal care products and fragrances, production of plastics, surfactants, and stain treatment. We also identified over 50 novel chemicals with limited to no information on their uses or sources and found significant associations between exogenous and endogenous compounds, several chemical groups (siloxanes, PFAS, and chemicals used in plastics and rubber) and biomarkers of lipid metabolism and regulation, supporting a link to gestational diabetes. For our renewal project, we propose to expand our study population by analyzing an additional 750 2nd trimester pregnancy samples, 300 of the samples matched to our original 3rd trimester samples. We will contribute to improved understanding of the prenatal chemical exposome by integrating NTA with improved computational methods including a chemical suspect database ~1,000,000 exogenous and endogenous chemical features in combination with upgraded software for supercomputing to identify ~500 chemical prenatal exposures and estimate their concentrations using new machine learning algorithms. We will use this data to characterize complex relationships between multiple exogenous chemical exposures, endogenous effect biomarkers, and maternal and perinatal health outcomes. The overarching goal of this renewal is to develop an integrated package of analytic and computational tools that allow expanded capacity to identify and calculate chemical concentrations and their link to adverse maternal and pregnancy outcomes, critical to information public health interventions to prevent harmful chemical exposures.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $557,390 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Environmental Health	000	8	7/2/2025	NON-COMPETING CONTINUATION	$557,390
														Subtotal = $557,390

Issue Date FY: 2024 ( Subtotal = $581,499 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Environmental Health	000	7	6/19/2024	NON-COMPETING CONTINUATION	$581,499
2024	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Environmental Health	002	6	9/17/2024	COMPETING CONTINUATION	$7,082
2024	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Environmental Health	001	5	9/17/2024	NON-COMPETING CONTINUATION	-$7,082
														Subtotal = $581,499

Issue Date FY: 2023 ( Subtotal = $594,108 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Environmental Health	000	6	9/11/2023	COMPETING CONTINUATION	$594,108
														Subtotal = $594,108

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Environmental Health	000	5	8/10/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $733,509 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Environmental Health	000	5	8/10/2020	NON-COMPETING CONTINUATION	$733,509
														Subtotal = $733,509

Issue Date FY: 2019 ( Subtotal = $1,025,775 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Environmental Health	000	4	7/26/2019	NON-COMPETING CONTINUATION	$1,025,775
														Subtotal = $1,025,775

Issue Date FY: 2018 ( Subtotal = $1,357,921 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Environmental Health	000	2	12/8/2017	SUPPLEMENT FOR EXPANSION	$324,929
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Environmental Health	001	3	8/22/2018	NON-COMPETING CONTINUATION	$1,032,992
														Subtotal = $1,357,921

Issue Date FY: 2017 ( Subtotal = $576,435 )
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Environmental Health	000	2	8/21/2017	NON-COMPETING CONTINUATION	$576,435
														Subtotal = $576,435

Issue Date FY: 2016 ( Subtotal = $591,581 )
2016	2016	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Environmental Health	000	1	9/21/2016	NEW	$591,581
														Subtotal = $591,581

Grand Total All Awards = $6,018,218

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Revealing environmental chemical exposome in a diverse prenatal population and relationships to maternal and perinatal health (REVEAL)

Award Number: R01ES027051

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2016

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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